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Eric Topol
@EricTopol
, 4 tweets, 3 min read Read on Twitter
Whoa. The gut #microbiome of elite athletes (marathon runners) has a bacterium that enhances performance, makes mice run longer, and this is mediated via lactate metabolism @NatureMedicine
nature.com/articles/s4159…
(file under more #microbiome amazing stuff)
Will the future of doping be crapsules for enhanced athletic performance? ;-)
In other gut #microbiome discovery news today, @BostonChildrens and @BrighamWomens investigators identified a pathway associated with food allergy and a bacterial therapy that might protect against them
nature.com/articles/s4159…
We're learning so much about both the human genome and gut #microbiome.
But the big expectations for the former seem to be getting more fulfilled of late by the latter.
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More from @EricTopol see all

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Eric Topol
@EricTopol
The human gut #microbiome never ceases to amaze me. Now a discovery of a bacterium that coverts Type A or B blood to type O, with big implications for blood transfusion.
nature.com/articles/s4156… @NatureMicrobiol by @PRahfeld Steven Withers and colleagues @UBC
Our gut #microbiome is a treasure for discovery. More coming out on this later this week that is mind-blowing.
BTW, another example of a striking finding that has not garnered coverage by any media. Surprising, in light of the public's interest in science.
Read 5 tweets
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Eric Topol
@EricTopol
Today new data marks an advance towards the individualized diet
1. We knew our glucose response to food was highly variable and unique
(work form @WeizmannScience @segal_eran and colleagues, reviewed here
nytimes.com/2019/03/02/opi…
2. At #ADA2109 and #Nutrition2019, @timspector and colleagues reported the same for triglycerides and insulin levels in a large cohort of twins. The variability was also noteworthy in identical twins.
nytimes.com/2019/06/10/hea…
@NYTScience by @cagraber @nicolatwilley
3. The results summarized, emphasizing that the variability in response to food in these 3 metabolic metrics is striking, that they don't track each other, and that much of the heterogeneity is not genetically determined. The gut #microbiome is an important driver.
Read 4 tweets
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Eric Topol
@EricTopol
The 1st drug (a monoclonal antibody) to delay onset of autoimmune #diabetes in high risk individuals (by ~ 2 years)
nejm.org/doi/full/10.10… #ADA2019 @NEJM #T1D @T1D_Trialnet
"The results of this trial are striking, with several caveats."
A long road that has taken 40 years. And still just a start to prevention.
Exciting, nonetheless.
nejm.org/doi/full/10.10… @NEJM editorial #ADA2019
by @clifford_rosen and @ingelfinger
'Herold procrastinated when it came time to analyze the data. “I kept pushing it off,” he says, because he worried about failure.'
Some interesting backstory to this major milestone trial
@sciencemagazine sciencemag.org/news/2019/06/m… by @jcouzin
Read 3 tweets

Related threads

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Amy Proal
@microbeminded2
Holobiont activity in chronic disease 👉In this analysis of #cardiovascular-disease-related proteins in human blood☝️genetics contributed most to immune-related proteins, while #microbiome contributed most to proteins tied to metabolism + intestinal health:nature.com/articles/s4158…
Worth noting that the team largely assumed that the proteins identified in #blood were derived from the gut microbiome 👉 but some #proteins could have been derived from organisms in the blood itself and/or organisms persisting in #microbiome communities outside the gut
Overall takeaway 👉 “This study provides important evidence for a joint genetic and microbial effect in #cardiovascular disease and provides directions for future applications in personalized medicine”
Read 3 tweets
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Elisabeth Bik
@MicrobiomDigest
Today, I am watching Episode 5 of the #Interconnected #microbiome series, called "Leaky gut - leaky brain - leaky kids".
interconnectedseries.com/episode5syo
Note: link will be disappear after 24h; after that you will have to pay.
My tweets will stay and are free!
The first part of the episode is mainly about the gut-brain connection. The main message is that you need to eat good food (fiber, vegetables) to send good signals to your brain. This is good information that can help many people.
But the summary of the first part, as given by the presenter on this slide, has some errors that should have been edited out.
1. "Enteroception" appears to be a vague term that only occurs 3 times in Pubmed, so there is no widespread scientific support for it.
Read 38 tweets
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Elisabeth Bik
@MicrobiomDigest
Earlier this week, I tweeted about Episode 1 of the #Interconnected series on the human #microbiome. See
Let's take a look at some other episodes (new thread).
The series features a mix of microbiome scientists, many of whom I have collaborated with and respect a lot, functional medicine doctors, and chronic disease patients. So, the documentary has a lot of great information, some inspiring stories, and some #FakeNews.
The problem with the series is that it is hard to distinguish between the correct and the incorrect information, especially if you are not a scientist.
By watching this series, you might learn a lot and be inspired, but please proceed with caution.
Read 22 tweets
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Bruno van Wayenburg
@brunchik
de tweetstorm die terugkwam, deze keer netjes gebundeld zoals het heurt:
lichte en zware voorwerpen vallen even snel, dacht Galileo al (als je even buiten de luchtweerstand rekent)
1/20
gek eigenlijk: andere natuurkrachtenkrachten dan de zwaartekracht -magnetische krachten, statische elektriciteit- werken helemaal niet zo.
2/20 #equivalentieprincipe
Hoe zwaarder een voorwerp, hoe harder zwaartekracht trekt. Dat is de zware massa. Maar ook: hoe zwaarder een voorwerp, hoe trager het op gang komt, dat is de trage massa. #equivalentieprincipe
3/20
Read 20 tweets
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Debra Matheny(Koski) #ISTANDWITHGENFLYNN
@DebMatheny
🗣#Rockefeller, #Clark, #Freeman, #DuPont, #Olson, etc, you need to learn the names, Minnesota! Unfortunately, they're carved in my heart💔 The Committee of 300, start there👊 Minnesota has been under satanic siege for over a half a century & #WalterMondale has had huge influence
en.m.wikipedia.org/wiki/Walter_Mo…
Read 6 tweets
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Haydar Şahin
@haydarsahinn
1. CERN: Evren aslında olmamalı! demiş. Ancak en nihayetinde buradayız, varız. Bunu biraz daha açalım.
2. #CERN yani Avrupa Nükleer Araştırma Merkezi. İnsanlığın gördüğü en büyük laboratuvar olma namını taşıyor.
3. Bünyesinde toplamda 3 binin üzerinde insan çalışıyor ve 10 bine yakınının da dışarıdan katkısı var.
Read 52 tweets

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#equivalentieprincipe #tweetorial #synergy #Clark #PedoRing #GreatThingsAreHappening #IRoS #criticalcare #imagine #FakeNews #HiAP #CERN #LEOS #ChildTrafficking #Cult #Interdependence #Pedophile #Seattle #blood #TORTURE #WEIRDPeopleProblem #ICU #Resistance #Elite #BlackLivesMatter
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