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Amy Proal
@microbeminded2
, 3 tweets, 3 min read Read on Twitter
Holobiont activity in chronic disease 👉In this analysis of #cardiovascular-disease-related proteins in human blood☝️genetics contributed most to immune-related proteins, while #microbiome contributed most to proteins tied to metabolism + intestinal health:nature.com/articles/s4158…
Worth noting that the team largely assumed that the proteins identified in #blood were derived from the gut microbiome 👉 but some #proteins could have been derived from organisms in the blood itself and/or organisms persisting in #microbiome communities outside the gut
Overall takeaway 👉 “This study provides important evidence for a joint genetic and microbial effect in #cardiovascular disease and provides directions for future applications in personalized medicine”
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#cardiovascular #microbiome #blood #proteins

More from @microbeminded2 see all

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Amy Proal
@microbeminded2
Yes 👉 And when #bacteria enter the #blood, they are even more likely to infect + persist inside the cells of the immune system 👉 There, the proteins + #metabolites they create can directly modulate the activity of human genes that regulate #metabolism + immune response etc
Also a growing # of organisms can persist in the #blood itself 👉 This @StanfordMed study found 1000s of never before discovered bacteria + #viruses in the blood of immunocompromised patients (99% of microbes identified were previously unknown to science): pnas.org/content/early/…
The team contends these newly discovered microbes 👉 “have potential consequences for human #health. They may prove to be the cause of acute or #chronic diseases that, to date, have unknown etiology”☝️This technology has not yet been used to study blood in conditions like #ME/CFS
Read 3 tweets
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Amy Proal
@microbeminded2
Microbes/viruses interact to drive disease 👉 Here, a #bacteriophage (Pf) that infects bacterial pathogen p. aeruginosa (Pa)☝️promoted Pa virulence (in wounds) by triggering maladaptive anti-viral responses in human cells + suppressing bacterial clearance: science.sciencemag.org/content/363/64…
In addition 👉 1. The data suggest that a natural (unmodified) #bacteriophage may be able to produce mRNA within human cells☝️2. Consistent with a pathogenic role for Pf #phage, a vaccine against Pf phage protected against P. aeruginosa wound infections in mice
Simple summary 👉 This marks the first time a #bacteria-infecting #virus, otherwise known as a #bacteriophage...has been observed inducing the immune system to mount an antiviral response and, in doing so, causing it to ignore the bacterial infection: google.com/amp/s/medicalx…
Read 3 tweets

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theavalondaily
@theavalondaily
#ANALYSIS Much has been said about young people running for various offices across the country - Ready Or Not?

While a host of them are simply making up the numbers, 3 have stood out remarkably and could win a seat each in the National Assembly. @BankyW @GRVlagos @RinsolaAbiola
We therefore will do a brief analysis of their chances tomorrow as they head to the polls.
@GRVlagos is a 35 year old Architect who ran for Ikeja local government chairmanship two years ago and lost. He is running for a seat in the Senate in the Largest senatorial district in Nigeria #Lagoswest on the platform of @OfficialPDPNig .
Read 20 tweets
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WarNuse
@WarNuse
European Union’s Highest Court Deals A Blow To Science.

By Gretchen Vogel, June 27, 2017.

We KNOW People Of Wealth Have Been Subverting Vaccines For Decades. There Needs To Be Room Made For These Criminals At Guantanamo.

sciencemag.org/news/2017/06/d…

#QAnon #GreatAwakening @potus
'Where There Is A Lack Of Scientific Consensus, The Proof Of The Defect Of The Vaccine And Of A Causal Link Between The Defect And The Damage Suffered May Be Made Out By Serious, Specific And Consistent Evidence.'

EU Report, June 21, 2017.

curia.europa.eu/jcms/upload/do…

#QAnon @potus
Gates Foundation Kicked Out Of India.

'The Gates Foundation Has For Years Funded ITSU Which Provides Strategy And Monitoring Advice For New Delhi’s Massive Immunization Program That Covers About 27 Million Infants Each Year.'

February 10, 2017.

newspunch.com/india-bill-gat…

#QAnon
Read 97 tweets
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Elisabeth Bik
@MicrobiomDigest
Here is my report from episode 4 of the #Interconnected #microbiome series. The title is: "Trouble With Toxins".
See: interconnectedseries.com/episode4rve.
The episode starts off with making us scared. The presenter says:
"We will look at the elephant in the room: The billions of pounds of toxins that are suffocating ourselves and our health. "
I am not sure how to fact check this, but this seems very hyperbolic.
At about 2m, we hear: "Since 1980, we have up to a 7-fold increase in type 2 diabetes. We've seen our population gone up from a very small percentage, maybe 10% obese, to now over 30% obese and 70% overweight."
Let's fact check.
Read 16 tweets
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Elisabeth Bik
@MicrobiomDigest
Earlier this week, I tweeted about Episode 1 of the #Interconnected series on the human #microbiome. See
Let's take a look at some other episodes (new thread).
The series features a mix of microbiome scientists, many of whom I have collaborated with and respect a lot, functional medicine doctors, and chronic disease patients. So, the documentary has a lot of great information, some inspiring stories, and some #FakeNews.
The problem with the series is that it is hard to distinguish between the correct and the incorrect information, especially if you are not a scientist.
By watching this series, you might learn a lot and be inspired, but please proceed with caution.
Read 22 tweets
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Nassim Nicholas Taleb
@nntaleb
There were no migrations in the Middle ages except towards empty steppes. #genetics #scholarshipwithoutBSishardIknow
2- Even places that underwent yuuuuuge ethnocultural changes such as Turkey show little gene flow. Turkey has tiny Turkic genes.

Historians are clueless about migrations.
3- Tiny rates of migration such as .5% per century can lead to big cumulative effects such as Subsaharan gene flow into Egypt ...
Read 8 tweets
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The Columbia Bugle 🇺🇸
@ColumbiaBugle
#Analysis: Ending #BirthrightCitizenship for the children of illegal immigrants and birth tourists has long been the crown jewel of pro-sovereignty immigration reformers. It's about interpreting the #14Amendment of the #Constitution correctly. Thread.
First, to quote the great Ann Coulter, it's laughable to think that any Founder, Framer or Amender of the Constitution intended for American citizenship to be the prize in a game of Red Rover with the Border Patrol. We're a nation of laws, after all.
Second, #14Amendment was one of three emancipation-related amendments to the #Constitution, designed to grant citizenship to former slaves and their children. The congressional record shows nobody believed 600,000 Americans died to give Congress the chance to open the borders.
Read 5 tweets

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