Thought provoking study. The oversimplistic view of sepsis we're taught is that it's a vasodilatory state with high cardiac output and high ScVO2.
Sure enough, ScVO2 was >70 in 65% of the cases in this study with likely optimal cardiac output.
Question. Why is there tissue hypoxia inspite of high ScVO2?
Answer - microcirculatory dysfunction (especially shunting) +/- mitochondrial dysfunction. The authors describe this as 'oxygen use impairment'.
Q. What explains low ScVO2 (and likely inadequate cardiac output) in sepsis.
Answer - Multiple potential reasons -
(ii) Dynamic LV outflow obstruction - DLVOTO from SAM or dynamic IVO from severe LV underfilling.
(iii) Severe septic cardiomyopathy with adequate MCFP but severely impaired inotropy. This is rare. Rx - inotropes and ensure preload optimization.