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My favorite papers challenge biomedical dogma. Here's my summary of the ones in 2019 that provided evidentiary shakeups (2nd annual list)
[let me know the ones I missed]
+ Annotation on the placenta from last year (#1 on the list)
We're back to dogma: it's sterile (de Goffau, Nature 2019)
This new review on Pseudogenes exemplifies the issue: "the trappings of the prevailing mindset that [these] regions are intrinsically non-functional"
nature.com/articles/s4157… @NatureRevGenet by @SethCheetham @MarcelDinger
@Faulkner_Lab @MaterResearch @QldBrainInst @UNSWScience
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Eric Topol
@EricTopol
Computer vision, label-free, #3D (really #4D) of live cells enables seeing things previously not visualized, like this cell division, and organelles, lipid droplets
@PLOSBiology journals.plos.org/plosbiology/ar…
by @PatrickSandoz @scilifelab @gvdgoot @epflSV @EPFL_en @EPFL & colleagues #AI
@PLOSBiology @PatrickSandoz @scilifelab @gvdgoot @epflSV @EPFL_en @EPFL Or accumulation of lipids in endosomes
@PLOSBiology @PatrickSandoz @scilifelab @gvdgoot @epflSV @EPFL_en @EPFL or the cellular dynamics of lipid droplets without perturbing organelle biology
Read 3 tweets
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Eric Topol
@EricTopol
A stern warning about the risk of #cancer associated with alcohol
by @theNCI's @Bill_Klein_NCI @pbjacobsen
jamanetwork.com/journals/jama/… @JAMA_current w/ the curious trade-off of less heart attacks thelancet.com/action/showPdf… @TheLancet 1/x
But 👇
@theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet 1. All this work relies on observational studies with drink diaries and shaky recall, and, at best, associations (not causality)
2. The naïve assumption is that all humans are equally responsive to #diet and beverage intake, which is reductionist and flawed 2/x
@theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet 3. We know the major predisposition genes for #cancer and can sequence these inexpensively to identify people who are at risk for both the monogenic types (#BRCA, Lynch syndrome, etc) and common, polygenic types (risk scores for breast, prostate, colon cancer. 3/x
Read 5 tweets
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Eric Topol
@EricTopol
The impact of the digital era on clinical trials is just beginning. While this chart shows impressive integration of sensors & apps, the next growth phase is site-less, direct to participant, fully digitized
digital.hbs.edu/data-and-analy…
@arieldora, H/T @RebeccaDRobbins @caseymross
@arieldora @RebeccaDRobbins @caseymross The digitized clinical trial was pioneered by @SteveSteinhubl and in this succinct piece @TheLancet the concept is developed
sciencedirect.com/science/articl… @ScrippsRTI @scrippsresearch
@arieldora @RebeccaDRobbins @caseymross @SteveSteinhubl @TheLancet @ScrippsRTI @scrippsresearch The 1st site-less, direct-to-participant, digitized clinical trial was designed to detect atrial fibrillation in patients at high-risk w/o symptoms, mailing them a sensor patch. Average age = 73!
jamanetwork.com/journals/jama/…
Done rapidly, at very low cost
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Diario La Opinión
@laopinioncucuta
#Fútbol | el encuentro entre Colombia y Brasil buff.ly/310mkOg
Con un gol de Casemiro, de cabeza, Brasil abre el marcador, al minuto 19, y le gana a Colombia 1-0
Gooooooooooooolllllllllll de @FCFSeleccionCol
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Roadie
@RoadieN60
Here, have another one: a prequel of sorts to the thread quoted here. May not have time to finish it until later, but gonna start it now.
👇
The sight of the creature startles her.

It is a strange feeling, to be startled. This place is predictable by design.
But there, under the willow tree, a creature huddles.

It must be part of His plan, Margarita thinks, as are all things. She pays it no mind.

But time and time again, she passes the great willow and sees the creature huddling there.

More strange: nobody seems to see it but her.
She passes the creature time and time again until she cannot simply pass it anymore.

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Edwin Hayward🦄🏹🗡️
@uk_domain_names
Here's Boris Johnson in more unguarded times, saying he would vote to stay in the single market. This deserves a lot of love, so you know what to do!
Here's a great summary of some of the most two-faced positions taken by Boris Johnson on the subject of the EU, the referendum and the importance of the single market. It won't surprise you to learn he can hardly stay consistent from one week to the next.
eu-rope.ideasoneurope.eu/2018/02/14/bor…
And here's another wrap-up (with some inevitable overlap) of times Boris Johnson called for us to stay in the single market...
businessinsider.com/boris-johnson-…
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Dr. Gabriela Bailas
@bibibailas
#FísicaThreadBr [Sou uma Física INVEJOSA?] Hoje vim falar sobre a inveja na Graduação. Pelo menos eu senti isso mais forte durante a minha. #CiênciaBr #ciencianobr
Eu lembro que alguns dos meus professores instigavam a competição de notas entre alunos, faziam questão de dizer a nota dos outros em voz alta e até mesmo humilhar os que não tinham a nota “tão alta”. Outros professores batem no peito pra dizer: comigo ninguém passa.
Naquela época quando eu era ingênua e não tinha aprendido a me impor, ainda não tinha mais de 10 anos na academia, achava normal. Normal pq eu só tinha aquilo como parâmetro. Então eu fui percebendo que eu sentia inveja de alguns colegas. Eu me pegava perguntando: quanto tirou?
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Georgia Dunn
@GeorgiaDunnBCN
I didn't excel in science as a kid, but I loved writing and art. I was always in the A or AP levels of English, and the B levels of Science. I had a tough time with sticking to steps, listing recaps in lab reports, etc, my mind just wasn't really there and never has been.
In 9th grade, while writing up a lab report I made a joke... And hesitantly ran with it. It went as follows:

Step 1: Turn on burner.
Step 2: Accidentally set lab partner on fire.
Step 3: Turn off burner.
Step 4: Find first aid kit.
And continued the lab report as it should have been for the assignment, peppering in references to an angry lab partner nursing a burn and trying to attempt to assist with one hand.
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postcardsforAmerica
@postcards4USA
Hey #NorthDakota
THREAD below of Voting Info & Democratic Candidates Congress, Sec of State, AG & State Senate with Links to all.
#Midterms2018
Check out this overview of the Voting numbers in #ND #PrimaryElection!
grandforksherald.com/news/governmen…
VOTE NOVEMBER 6, 2018!!
Democratic Candidate for Congress in #NorthDakota
Mac Schneider (D)
Ex-State Senate Minority Leader & Attorney
mac4northdakota.com
@mac4northdakota
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Democratic Candidates for Senator in #NorthDakota #ND

Heidi Heitkamp
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