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The impact of the digital era on clinical trials is just beginning. While this chart shows impressive integration of sensors & apps, the next growth phase is site-less, direct to participant, fully digitized
digital.hbs.edu/data-and-analy…
@arieldora, H/T @RebeccaDRobbins @caseymross
@arieldora @RebeccaDRobbins @caseymross The digitized clinical trial was pioneered by @SteveSteinhubl and in this succinct piece @TheLancet the concept is developed
sciencedirect.com/science/articl… @ScrippsRTI @scrippsresearch
@arieldora @RebeccaDRobbins @caseymross @SteveSteinhubl @TheLancet @ScrippsRTI @scrippsresearch The 1st site-less, direct-to-participant, digitized clinical trial was designed to detect atrial fibrillation in patients at high-risk w/o symptoms, mailing them a sensor patch. Average age = 73!
jamanetwork.com/journals/jama/…
Done rapidly, at very low cost
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Eric Topol
@EricTopol
Computer vision, label-free, #3D (really #4D) of live cells enables seeing things previously not visualized, like this cell division, and organelles, lipid droplets
@PLOSBiology journals.plos.org/plosbiology/ar…
by @PatrickSandoz @scilifelab @gvdgoot @epflSV @EPFL_en @EPFL & colleagues #AI
@PLOSBiology @PatrickSandoz @scilifelab @gvdgoot @epflSV @EPFL_en @EPFL Or accumulation of lipids in endosomes
@PLOSBiology @PatrickSandoz @scilifelab @gvdgoot @epflSV @EPFL_en @EPFL or the cellular dynamics of lipid droplets without perturbing organelle biology
Read 3 tweets
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Eric Topol
@EricTopol
My favorite papers challenge biomedical dogma. Here's my summary of the ones in 2019 that provided evidentiary shakeups (2nd annual list)
[let me know the ones I missed]
+ Annotation on the placenta from last year (#1 on the list)
We're back to dogma: it's sterile (de Goffau, Nature 2019)
This new review on Pseudogenes exemplifies the issue: "the trappings of the prevailing mindset that [these] regions are intrinsically non-functional"
nature.com/articles/s4157… @NatureRevGenet by @SethCheetham @MarcelDinger
@Faulkner_Lab @MaterResearch @QldBrainInst @UNSWScience
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Eric Topol
@EricTopol
A stern warning about the risk of #cancer associated with alcohol
by @theNCI's @Bill_Klein_NCI @pbjacobsen
jamanetwork.com/journals/jama/… @JAMA_current w/ the curious trade-off of less heart attacks thelancet.com/action/showPdf… @TheLancet 1/x
But 👇
@theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet 1. All this work relies on observational studies with drink diaries and shaky recall, and, at best, associations (not causality)
2. The naïve assumption is that all humans are equally responsive to #diet and beverage intake, which is reductionist and flawed 2/x
@theNCI @Bill_Klein_NCI @pbjacobsen @JAMA_current @TheLancet 3. We know the major predisposition genes for #cancer and can sequence these inexpensively to identify people who are at risk for both the monogenic types (#BRCA, Lynch syndrome, etc) and common, polygenic types (risk scores for breast, prostate, colon cancer. 3/x
Read 5 tweets

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Philippe Smet
@pfsmet
The #phyphox app from @rwth_phyphox gives you direct access to the output of many #sensors in your smartphone. Next time you have a long ✈️flight, quantify turbulence or just check on your phone when the toilet rush is over. (Warning: #scicomm #physics thread ahead!👇) 1/n
Your #phone is full of #sensors (microphone, camera, temperature, GPS, light sensors, magnetometers,…), including air pressure sensors and accelerometers. The pressure at cruising altitude is about 80% of the pressure at sea level. 2/n
That’s why your crisps package expands after take-off and the empty plastic bottle appears auto-crushed after landing. The pressure sensor can be used to estimate elevation when being on earth. But it is so sensitive it feels when airplane toilets are flushed. 3/n
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Strykr VII
@StrykrSeven
EVEN CONSUMMATE VICTORY IN THE BATTLE FOR THE SOUL OF AMERICA WON'T END THE WAR
There is a terrible truth lurking behind Donald Trump that is far more important than 2020. We've dared not whisper this truth because it's more terrifying than anything we can currently comprehend.
1/ What is this wretched, unspeakable truth? Quite simply, that all of human civilization itself experienced *astoundingly good fortune* that DONALD J. TRUMP (of all people!) was elected head of state and supreme commander of Earth's greatest military superpower.

Seriously.
2/ Donald Trump is a bad man, and he must lose in 2020. No sane person would disagree with this. But his mere defeat is not the end of this war, not by a long shot. Without a supportive Congress, a President is essentially powerless to advance legislation on their own.
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Traders8
@Traders82
#Chapter2 : Trend Trading .

Traders first priority is to take a trade basis the trend. Trend in simple terms means, following the direction of the Market.

Which also means, being with the forces who create the direction, who drive the prices, who move the market, SmartMoney.
What is Smart Money ?

Traders Small or Big who buy or sell in large quantities and have the money power to play with prices by buying or selling at important price points.

They decide if the Price is Undervalued for a Buying Opportunity or Over Valued for Selling Opportunity.
As the Buying or Selling happens in Bulk, their Profitability depends on How far they can push the price, so that they can cover whole of their orders with out loosing much.

They have the power to hold positions and keep rolling it over for Years or Decades if they decide to do.
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mcm-ct.com
@mcm_ct
#Chart #EXTRAVAGANZA

Please read the whole thread - will start posting now...but eating dinner so will take a while to get the 30 to 40 tweets done

/1
Given the two crashes in one year and the recent #FANG blow up...how much cash do you think Mutual Funds are holding? How about the lowest ever!

More over their allocations to Stocks remain among the highest ever.

/2
And how are those stock/equity investments postured?

We’ll very precariously as #NYSE and #Nasdaq #Composite show...completely stopped at major resistance...not only that there is the breadth question which we will address later and is terrible

/3
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Lindsay Brown
@Lidsville
Today the First Nations challenge to #SiteC in BC Supreme Court resumes, asking for an injunction to stop work on the dam until the rest of the Treaty 8 infringement case is decided in court. A critical case for BC. Follow the #SiteC & #SiteCInjunction hashtags this week! #bcpoli
Heading over to 800 Smithe now for 9:45 entry. All are welcome to be in the courtroom - please join us. Latecomers not admitted; proceedings start 10 am sharp. #bcpoli
This final week of the #SiteCinjunction hearing involves lawyers from the Province of BC (we have already heard from @sage_legal on behalf of West Moberly & Prophet River FNs, and BC Hydro's lawyers. #bcpoli #SiteC
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Jason Wright
@jasonawright7
1. The sleeping giant is slowly awakening to the corruption that is enslaving us all.

Once this giant has fully awoken we shall be unstoppable.

Public awakening is their greatest fear.

#QAnon @POTUS @realDonaldTrump
2. It’s essential that #WeThePeople understand how #Corruption in the pharmaceutical industry has a stronghold on people.

#QAnon @POTUS @realDonaldTrump
3. This long & detailed thread will shine light on corruption in the vaccine and cancer industry.

These are complicated & touchy parts of the #DeepState rabbithole for obvious reasons but facing the #Truth is very important.

The truth shall set everyone #free.

#QAnon @POTUS
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