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1/ As usual, I head straight to the methodology to see if it is at least wild type mice eating a species appropriate diet.

Well...
2/ This is why I avoid these kinds of studies. Mice genetically prone to obesity & diabetes get obese and diabetic.

And FWIW, I couldn't find what their diet actually was. But I'm skeptical it resembles anything advocated in the #keto community. (Anyone know with this study?)
3/ What I *would* be interested in -- is what I outlined above.

How about just feeding wild type a wild type ketogenic diet? Let's see if they get obese on an unprocessed, whole food diet high in fatty meats and cheeses.

You can guess what I'd be betting in that scenario.
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Dave Feldman
@DaveKeto
1/ Thread: The evidence I’m looking for.

One thing that I realized I haven’t taken the time to lay out is the evidence I’ve been searching for — literally since Nov’ 15 when I started this journey:

*Genetically low LDL associating with lower all cause mortality*
2/ That was the most intuitive way to test the lipid hypothesis fully as it would suggest reduction of LDL associating with lower CVD had a net benefit to longevity when compared to the general population.

Genetically less LDL => longer lifespan than overall population
3/ There are many factors I’m particularly interested in that make a study (*any* study) more compelling for me:

(A) Minimal modification. Generally, the less one-off modeling, extrapolating, and unusual exclusions being applied, the more I like it.
Read 13 tweets
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Dave Feldman
@DaveKeto
1/ Wanted to take a moment to express my thanks to @AviBittMD who took some time to chat with me regarding questions I had on the Copenhagen study we were discussing yesterday. Alas, there’s a few different abstracts, but only one published study...
2/ But it’s claim regarding LDL SNPs of PCSK9 vs all cause mortality (ACM) is something I’m very interested in. I don’t know much about the Copenhagen dataset, but assuming it is well collected, the methodology used is clean, and the effect size clear, that would peek my interest
3/ I want to make this clear before having the information in hand for maximum intellectual honestly. Provided there’s no creative methodology or selectivity with the data (preferably complete population, full follow up time possible, etc), then I’d consider this very compelling
Read 4 tweets
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Dave Feldman
@DaveKeto
1/ Thank you, Danny — this is a considerably important topic for me, of course.

“Atherogenic dyslipidemia” (AD) is already commonly addressed in the literature and defined as having low HDL and high triglycerides (along with a high preponderance of small dense LDL particles)...
2/ In a sense, the “low carb lipid triad” (⬆️LDLc+⬆️HDLc+⬇️TG) I’m interested in is nearly the opposite of AD.

This is especially relevant to the topic — as I hypothesize when ApoB is matched with ⬆️HDLc+⬇️TG, we will frequently see it showing low rates of cardiovascular disease
3/ This is part of the problem I have where looking at either non-HDL or ApoB —> both lump remnants together with LDLc/p

If we know atherogenic dyslipidemia with low levels of LDLc/p has a high rate of atherosclerosis, why not be interested in the reverse as well?
Read 4 tweets

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Victor Levandovski
@vlevandovski0
Thread on my journey to a meat-based diet.

1) In summer 2019 I changed my diet. Now I eat mostly meat, plus dairy products except milk. Sometimes I eat cooked vegetables, mostly when eating outside. I only drink water, coffee low on caffeine, and alcohol.

#diet #carnivorediet
2) After I reached about 27, I started noticing my stomach is not able to process any junk I put in it. Once or twice per year, I would get a mild form of acute pancreatitis. I would get diarrhea if I drink cold Coke after a meal.
3) Then it became worse, I could have diarrhea without obvious reasons. In general, the consistency of my stool was getting softer and softer. I also started noticing weird red dots on my legs, correlating with diarrhea and other stomach issues.
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Matthew J. Becker 🌟🌟🌟
@MadAddictSport
#See Cannes Yacht Club
#See Gadaffi Sex Prostitution Ring
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Filipe De Vadder
@FilipeDeVadder
[MICROBIOTA JOURNAL CLUB] A new paper published in Science goes wild on mice. Let's take a look at the story:
dx.doi.org/10.1126/scienc…
[Ça arrive en français dans la foulée]
For those not familiar with laboratory mice, the most commonly used mouse in a lab is a strain called C57Bl/6J. This strain was developed in Jackson Laboratories from the original C57Bl strain obtained in 1921. It is an inbred strain, so genetical variations are minimal.
Besides, mice are kept in clean and pathogen-free facilities (ranging from conventional to SOPF), so the environment is far from that encountered by wild mice.
jax.org/strain/000664
Read 30 tweets
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Kelly Issokson MS RD
@GIdietitian
Recent case report published in @Nutrients_MDPI claims vegetarian #diet induced remission in Crohn’s disease and has been promoted as a “cure” by @gizmodo. (spoiler: there is no current cure for #IBD) 1/
link to study: mdpi.com/2072-6643/11/6… 2/
The patient in this study had a colonoscopy which showed moderate Crohn’s disease. He was started on a biologic (infliximab) and “significantly” improved clinically but had ongoing symptoms (abdominal pain, fatigue, bloating). 3/
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Matthew J. Becker 🌟🌟🌟
@MadAddictSport
#See Huawei Poland: @Avery1776
@BenKTallmadge @CarrollQuigley1
jamestown.org/program/arrest…
usnews.com/news/articles/…
A great read:

nytimes.com/2013/11/23/us/…
Read 3 tweets
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la scapigliata
@lascapigliata8
Yesterday I had a pointless discussion with TRAs who couldn't understand why any study on transgender people that doesn't account for homosexuality as a variable is flawed. It's because whenever it is accounted for, this happens 👇
This study was reported in the media under such headlines as "Transgender people’s brain activity matches gender identity, not biological sex". Study wasn't linked, and unless you have access to PubMed and the original journal, you won't be able to read it. However
When you do get to read the article, one thing immediately jumps out:
"Most transgirls and all adolescent cisgender girls were androphilic and all transboys and adolescent cisgender boys reported to be gynephilic".
Read 20 tweets

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