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"He's waited a week without the drugs"

Just like FDA blocked lab tests for the US, next it's going to block drugs.

We need emergency expanded right-to-try laws now. Push approval to state regulators such that new drugs like remdesivir can be tried fast.
gilead.com/news-and-press…
As more context, the first US #COVID19 patient was in worsening condition until local regulators approved compassionate use of remdesivir on day 7. On day 8 he improved. China put the drug into clinical trials a few days later.

Here's the NEJM article:
nejm.org/doi/full/10.10…
Of course, safety is easier to establish than efficacy. We don't know if every new drug will work.

But if someone has a life-threatening disease that can take a sharp turn for the worse in an hour then they need the right to at least *try* & need it now.
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Balaji S. Srinivasan
@balajis
My one edit to this:

I don't think it's practical to "end" the FDA, anymore than it was practical to "end" the Fed

Too much infra around it, can't replace overnight

Instead, do it like crypto. Route around with an alternative

Here, that's expanded right-to-try at state level
That is, if you say "end" the Fed or FDA, it works as slogan but the establishment doesn't take it seriously. These institutions are the core of the whole system, all backlinks go into them, can't just set that to zero.

The real threat is to *build the alternative*.
All Bitcoin needed was the right to exist.

Technological decentralization ensured it couldn't be easily shut down by any state. And then once that alternate pathway existed, it started outcompeting* the Fed's dollar over the long-term.

* Yes, down now, but up >10000X since '10
Read 7 tweets
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Balaji S. Srinivasan
@balajis
The 2020s will be the decade of biomedicine. Almost everything else may crash but budgets for this will be unlimited.

Founders should consider joining Illumina, Roche, GSK, etc to learn skills. And learning how to "biohack" at home.
medium.com/@ThatMrE/a-gui…
What the internet was to software, or crypto was to finance, the virus will be to biomedicine.

It is going to decentralize it, accelerate it, make it highly personal, cause an enormous surge of new talent into the area, and (most importantly) change the risk calculus.
The risk calculus part is important. Up until this point, the cost of biomedical delay was invisible and deniable.

But what FDA's CDRH division did in terms of delaying EUAs for lab tests has now very publicly cost us trillions of dollars and likely many American lives.
Read 7 tweets
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Balaji S. Srinivasan
@balajis
Quarantine theater?

It appears the US right now is doing half-ass TSA-ish things.

Rather than a short, sharp, universal lockdown it is taking huge economic damage without the full health benefit. If we're doing this, we need to do it like Asia or Israel would do it. ImageImage
Measuring success requires:

1) massive diagnostics capability for the foreseeable future
2) centralized site to collect these stats

We need (1) because this is an infectious disease, so people will need to be retested many times. We need (2) to get a scoreboard.
US government dysfunction means we'll need to do this the hard way: the decentralized response.

Testing is ramping now that it's finally outside the FDA/CDC bottleneck (see below).

Our general mental model must be: the state will mess it up, so we need to monitor & decentralize Image
Read 6 tweets

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Bill Pulte
@pulte
I just spoke to a 32 year old CoronaVirus Patient (who is a medical professional and not an alarmist) says the virus is worse than people think. His lungs are shutting down, and he says he will have to be intubated soon. He's waited a week without the drugs that he wants
He wants to be moved from New Jersey to New York City where he can get more adequate care, and also get the drugs that his family says are working in China. Patient says that hospital staff is looking at him like an animal and won't get near him. They ask him to face the wall.
I'm helping James because he needs a patient advocate right now. His family reached out to me. We don't need panic or hysteria. We need to be prepared for our love ones when they are sick. James's lungs are shutting down, he has a young daughter, just like me.
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Filomena Rocha
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8.🗣️📢Alert World leaders, citizens of the world, is attempting a coup d'état in #Bolivia.
🗣️📢Do not let that happen.
🗣️📢Evo Morales is one of the great leaders of the 21st century.
🗣️📢Protect democracy
🗣️📢Protect Bolivia
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1. 🗣️📢Alert World leaders, citizens of the world, is attempting a coup d'état in #Bolivia.
🗣️📢Do not let that happen.
🗣️📢Evo Morales is one of the great leaders of the 21st century.
🗣️📢Protect democracy
🗣️📢Protect Bolivia
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🗣️📢Do not let that happen.
🗣️📢Evo Morales is one of the great leaders of the 21st century.
🗣️📢Protect democracy
🗣️📢Protect Bolivia
threadreaderapp.com/thread/1191853…
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Filomena Rocha
@Filomen03258997
6.🗣️📢Alert World leaders, citizens of the world, is attempting a coup d'état in #Bolivia.
🗣️📢Do not let that happen.
🗣️📢Evo Morales is one of the great leaders of the 21st century.
🗣️📢Protect democracy
🗣️📢Protect Bolivia
#regimechange #ProtectBolivia #ProtectDemocracy
1. 🗣️📢Alert World leaders, citizens of the world, is attempting a coup d'état in #Bolivia.
🗣️📢Do not let that happen.
🗣️📢Evo Morales is one of the great leaders of the 21st century.
🗣️📢Protect democracy
🗣️📢Protect Bolivia
threadreaderapp.com/thread/1187148…
2. 🗣️📢Alert World leaders, citizens of the world, is attempting a coup d'état in #Bolivia.
🗣️📢Do not let that happen.
🗣️📢Evo Morales is one of the great leaders of the 21st century.
🗣️📢Protect democracy
🗣️📢Protect Bolivia
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Richard James
@RichJamesBits
I have reached a whole new level of #PISSEDOFF.

I didnt think such a #dark and #scary state, or level, could be reached. It may top 12-14-17's causation. It's. That. Bad. So, I've prepared a statement...

docs.google.com/document/d/1_J…

#PascoSheriff #HaveYouAllNoShame @CigarCityBeer
Dear @FBI,
I must implore you ask your colleauges in @FBITampa to help research this new level of #PISSEDOFFNESS. As locals, they may offer a special indepth knowledge of this new level I have reached. This is not fair & law enforcement must #investigate. No one deserves this.
This is my #apogee of #Pissedoffness.
If #motherfuckers & #tears werent a noticable level.
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If posting mom with no shred of investigatable value wasnt enough...
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