New @polybioRF podcast. I interviewed Dr. Tobias Lanz: MD + researcher in the lab of Prof. William Robinson at the Department of Rheumatology/Immunology at Stanford School of Medicine. Listen on Spotify (open.spotify.com/episode/4bTQss…) or watch on Youtube ()
2/ In the interview Tobias discusses this breakthrough study he led at Stanford. It showed that a cross-reactive antibody can contribute to #MS neuroinflammation thanks to molecular mimcry b/t an EBV viral protein (EBNA1) + a human CNS protein (GlialCAM): nature.com/articles/s4158…
3/ Tobias also describes this recent Harvard study which further implicates #EBV as a driver of MS. He talks about treatment for MS now that #viral activity is understood to be at the heart of the disease process: science.org/doi/10.1126/sc…
4/ Overall the interview explains the mechanisms by which #infection can lay at the root of “autoantibody” production.
5/ And Tobias delineates how researchers can now use advanced technologies + techniques (from the ability to isolate single B cells from patient cerebrospinal fluid, to the creation of crystal structures of pathogen proteins that may be mimicry targets) to explore that phenomenon
6/ The findings have implications for #ME/CFS + #LongCovid. B/c we can identify certain autoantibodies in such patients. But where do they come from? Can they also arise as a result of molecular mimicry b/t pathogen + host proteins? We need to start doing the research to find out
7/ @TobiasLanz
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