Regular #exercise effectively reduces #headache days in patients with #migraine

1. Migraine is a disabling disease that causes repeated episodes of headaches.
Exercise is very effective, however, it is uncommonly prescribed in migraine.
#MedTwitter #neurotwitter
2. In a recent research, strength/resistance training reduced monthly migraine days (MMD) by 3.5 days, followed by high-intensity aerobic exercise (3.1 days) and moderate intensity aerobic exercise (2.2 days).
3. All exercise modalities showed higher efficacy compared to placebo.
The reason for strength/resistance training to rank top could be because of targeted muscular strengthening and reconditioning, particularly involving major muscles in the neck, shoulders and upper limbs.
4. Neck pain is highly comorbid with migraine in clinical populations. The nociceptive input from neck structures of the upper cervical spine is connected with the trigemino-cervical system, the neuroanatomic spot of migraine disorders.
5. Local metabolic and neuromuscular adaptations and the related strength increase induced by neck strength exercise could be putative mechanisms underlying the therapeutic effects of neck exercises.
6. Aerobic exercise-mediated pain-relief involves both opioid and endocannabinoid systems. Migraine has been linked to a deficiency of both opioidergic and endocannabinoidergic signaling.
7. Interestingly peripheral endorphin secretion and brain opioid receptor binding occur preferably during high-intensity rather than moderate aerobic exercise, while endocannabinoids (anandamide) are released preferably during moderate, rather than high-intensity aerobic exercise
8. Another reason why strength/resistance training outperformed aerobics exercise in reducing migraine burden could be related to its higher capacity to increase/preserve lean muscle mass and combat sarcopenia (while still losing fat) compared to aerobics.
9.Increased lean muscle mass is known to be associated with reduced migraine frequency. Moreover, increment/preservation of lean body mass has been shown to combat central sensitization in chronic pain syndromes. Weight loss involving fat loss is seen in strength training.
10. Conclusion:
Combination of #StrengthTraining and #aerobic exercises is highly effective in reducing migraine attacks.
Exercise helps in reducing obesity, depression and insomnia, which commonly co-exist with migraine.
Exercise should be prescribed for migraine treatment.
Another interesting fact that emerged in this study was that all forms of exercises were more effective than topiramate and amitriptyline- two commonly used anti-migraine medications. Though not the final word, it does give a signal to patients with migraine.

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Nov 28
Case of a man who almost stopped eating and drinking, as the act of swallowing caused severe throat pain

1. 45-year old man presented with intense episodes of pain in throat, back of tongue and tonsils on the right side for three months. The pain radiated to ear.
#MedTwitter
2. #pain was excruciating and was triggered by eating, chewing or swallowing food, drinking water, sneezing or even yawning. Pain lasted for 30-45 seconds and occurred 10-15 times every hour. He was so scared to eat or drink that he lost 15 kg weight in those 3 months.
3. He consulted ENT and dental doctors, and detailed examination by them was normal.
He became depressed and also had suicidal thoughts. He consulted psychiatrist and was started on anti-depressant medications.
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1. Patient: My BP is high only in hospital, at home it is normal. So, I don't want to do anything about it.
Me: High BP (whether in hospital or at home) can lead to adverse outcomes, so, you should aim for a normal BP 24/7.
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Nov 27
Calcium supplements increase the risk of dementia inn older people

1. #Calcium tablets are commonly prescribed to older people to lower the risk of #osteoporosis and #fractures. However, calcium tablets may increase the risk of #Dementia.
#neurotwitter #MedTwitter
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The risk of dementia was higher in women with previous history of #stroke and those with white matter lesions (WML) on #MRI brain.
3. In another study, higher serum calcium status (even if not hypercalcemia) was associated with increased risk of #Alzheimers disease in elders. Serum calcium is a useful biomarker in predicting clinical progression in nondemented elders.
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Cause of coma in a #woman surprised us!

1. 65-year old woman was brought in an #unconscious state to #emergency dept. She sounded normal over phone to her son about 24 hours earlier. She stayed alone, so, further details were not available.
#MedTwitter #internalmedicine
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3. Serum #calcium was high (13 mg/dL). MRI brain was normal. Lumbar puncture was normal. Investigations were done to determine the cause of high calcium. There was no evidence of #endocrine disorder, infection or #Cancer.
#VitaminD level was very high (160 ng/mL).
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Can #drinking excess amount of #water lead to death?

1. Water is life-saving and is essential for survival. However, ingestion of excess amounts of water, especially over a short period of time can lead to serious health hazards, including #death.
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2. How much water is needed on daily basis?

The normal daily requirement of water is 2.5 to 3 liters.
The requirement may be higher in summer months. Requirement also increases during #exercise (due to sweating), during fever, diarrhea or vomiting.
3. Why do some people drink excess amounts of water?

There is a misconception that drinking more water is good for #health.
Some people can drink more water due to #psychiatric illnesses.
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Long-standing unwanted & unpleasant genital sensations in a woman of neurological origin

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