The ketogenic diet restricts carbohydrates with the purpose of lowering insulin levels. Insulin is a hormone that is involved in fat metabolism. Therefore, some suggest that a ketogenic diet is very effective for fat loss.
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This study investigated whether a ketogenic diet increases fat loss compared to a high-carbohydrate diet in overweight and obese men.
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The high carbohydrate and the ketogenic diet contained the same calories (individualized to the subject) and protein. After a 2 wk high carbohydrate baseline period, the subjects received a 2 wk high-carbohydrate diet, followed by 4 wks of the ketogenic diet.
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Fat loss decreased during the first 2 wks of the ketogenic diet. Nitrogen excretion was also increased, suggesting there was an increase in the use of body protein for fuel. During the last 2 wks of the ketogenic diet, fat loss was not different from the high carbohydrate period
A massive strength of this study was that the subjects stayed in a metabolic ward, so that all meals could be provided and supervised. However, metabolic ward studies are very demanding and costly. Therefore, the study and had relatively little subjects and was relatively short.
It is sometimes suggested that full adaptation to a ketogenic diet may take several weeks, and therefore benefits only become noticeable after several weeks. While we cannot exclude this possibility, the currently available data suggests it may just be wishful thinking.
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This study is in line with an abundance of evidence that shows that calorie balance is the main determinant of fat loss, and that there is no clear metabolism βhackβ.
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In conclusion, the ketogenic diet does not increase fat loss compared to a high-carbohydrate diet.
Our new paper:
Pre-sleep Protein Ingestion Increases Mitochondrial Protein Synthesis Rates During Overnight Recovery from Endurance Exercise: A Randomized Controlled Trial
Prostate cancer is one of the most common types of cancer. An effective treatment is androgen deprivation therapy (ADT), which lowers testosterone levels to castration levels. However, such low testosterone levels tend to result in a loss of muscle mass and strength.
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Our study investigated the effect of resistance training with or without protein supplementation on muscle mass and strength in prostate cancer patients undergoing ADT.
Exercise and protein ingestion are the main factors that stimulate muscle protein synthesis (the main process driving muscle adaptations such as growth).
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It has been reported that athletes are more likely to consume excessive amounts of alcohol, especially as part of binge-drinking practices in team sports. Can these practices affect muscle protein synthesis?
Muscle growth occurs when muscle protein synthesis exceeds muscle protein breakdown. Resistance exercise stimulates both muscle protein synthesis and breakdown. Ingestion of protein further increases muscle protein synthesis and is needed to achieve positive protein net balance.
In young adults, 20 g of high-quality protein seems optimal to stimulate post-exercise muscle protein synthesis. However, is this also true for older adults?
Aging is associated with the loss of muscle mass. This phenomenon is also known as sarcopenia. Around what age does this start to occur?
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This study investigated the influence of age on muscle mass in a large sample of adults. Skeletal muscle mass was measured with a whole-body MRI for 468 adults of 18-88 years old. People that were bedridden, had physical disabilities, or had chronic illnesses were excluded.
Aerobic capacity is defined as the maximal rate of oxygen consumption (VO2max). A large improvement in aerobic capacity can already be achieved during an intense 10-week training program.
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Non-responders to exercise probably donβt exist. However, there are people that need a lot more exercise volume to obtain the same fitness benefits compared to others.