1. You pick a "value ball" from an urn
2. Each ball is two triples of {profit, probability, arrival time}, one with treatment, the other without
3. You can buy one treatment outright
5. You can also buy unlimited tests
6. Tests updates your info about at least one variable in your current treatment
7. Variable cost, "burn rate" is constant until arrival time
8. You can terminate at any time
10. Payoff at arrival is profit based on treatment minus burn
11. Add discounting and other embellishments if you feel like it
12. Of all observed paths to arrival, treatment has produced higher net profit than no profit
13. That doesn't mean any individual treatment will
14. E.g. treatment can increase profit but lengthen path to arrival
16. Tests can be purchased from experts
17. Experts have an-above average profit portfolio for all paths on which they administered tests
18. You can't observe *any* counterfactual paths
19. Tests are both cost and effort intensive, so will move back arrival time
20. You can use tests and experts at any time, concurrently or sequentially, but
21. Experts can and will disagree over variables, leaving you to interpret their estimates
22. Treatment can't just be applied at the beginning, but anywhere along the path at any intensity, leading to an unobserved triple {profit(τ), probability(τ), arrival (τ)} depending on treatment intensity τ
10. Payoff is *profit times probability* based on treatment minus burn
- Arrival time typically measured in years, one or two decades are normal
- Payoffs vary significantly
- Probabilities vary by ε, and typically start in the single digits
- Effect of treatments = ???
- Effect of testing = ???
Beers on me... 🍻
This is a drug discovery funnel.
This is pretty much any corporate R&D pipeline.
It's also an academic paper selection process.