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A 68 y o male with type-2 DM, CAD, CCF (EF~35%), PAD, and history of gouty arthritis presented with dyspnea and LL edema.
Which of the following drugs is appropriate therapy for his edema?
A) Furosemide
B) Indapamide
C) Empagliflozin
D) Bumetanide
E) Metolazone
#cardiotwitter
Which of the following drugs is appropriate therapy for his edema?
A) Furosemide
B) Indapamide
C) Empagliflozin
D) Bumetanide
E) Metolazone
#cardiotwitter
Correct answer is (C)
Hyperuricemia is a common adverse effect of loop or thiazide diuretics and may precipitate acute gouty arthritis.
Treating type-2 DM with an SGLT2 inhibitor promotes osmotic diuresis, natriuresis, and reduces uric acid by increasing its excretion.
Hyperuricemia is a common adverse effect of loop or thiazide diuretics and may precipitate acute gouty arthritis.
Treating type-2 DM with an SGLT2 inhibitor promotes osmotic diuresis, natriuresis, and reduces uric acid by increasing its excretion.
Lowering uric acid by SGLT2 inhibition reduces CV events and slows the progression of CKD in type-2 DM.
SGLT2 inhibition is useful in the treatment of gout and gouty arthritis, especially when co‐existent with diabetes.
onlinelibrary.wiley.com/doi/full/10.11…
SGLT2 inhibition is useful in the treatment of gout and gouty arthritis, especially when co‐existent with diabetes.
onlinelibrary.wiley.com/doi/full/10.11…
It has been shown that Empagliflozin (SGLT2 inhibitor) is an appropriate choice in patients with type-2 DM and atherosclerotic CV disease to reduce CV mortality and hospitalization for heart failure.
ahajournals.org/doi/10.1161/CI…
ahajournals.org/doi/10.1161/CI…
One more thing:
The cost of a one-month supply of empagliflozin is approximately $410, while the price for furosemide is around $4.0.
Cost remains an issue!
The cost of a one-month supply of empagliflozin is approximately $410, while the price for furosemide is around $4.0.
Cost remains an issue!
