Thread by @JLRohmann

Now @BEMColloquium , @shell_ki begins her talk on life course epidemiology, focusing on inequalities in health

@BEMColloquium @shell_ki The socioeconomic gradient in health

@BEMColloquium @shell_ki Why does your job type or parents' job affect your health? What are these underlying social constructs/processes? Guiding questions....

@BEMColloquium @shell_ki Exploring ways how the social becomes the biological.

@BEMColloquium @shell_ki Nancy Krieger... Concept of embodiment... How we adapt and change physiologically to our environment. Discussion of relevance of lifecourse over time (example: consumer price index over time)

@BEMColloquium @shell_ki Similar ideas emerging across different disciplines... Some examples

@BEMColloquium @shell_ki Interuterine exposures to famine have long term consequences decades later

@BEMColloquium @shell_ki Again, looking to another discipline for more evidence (neuroscience) on influences of environment on development throughout childhood

@BEMColloquium @shell_ki Tolouse research group: conceptualizes two distinct broad types of biological mechanisms.

@BEMColloquium @shell_ki Focusing on endogenous mechanisms... One type: stress response system

@BEMColloquium @shell_ki In an animal and human literature review, chronic physiological stress appears to have different effect on the body at different points in the lifecourse

@BEMColloquium @shell_ki

@BEMColloquium @shell_ki Pre-disease state: we can start to capture this disregulation happening before we see people presenting with diseases

@BEMColloquium @shell_ki Obvious ethic constraints on doing experimental models for stress on humans... So we need other tools to investigate

@BEMColloquium @shell_ki

@BEMColloquium @shell_ki Empirical examples... This cohort is still collecting data.

@BEMColloquium @shell_ki Comparison of ACE framework (WHO)... Discussion of use as a research rather than diagnostic tool

@BEMColloquium @shell_ki Creating an allostatic load score....

@BEMColloquium @shell_ki Discussion of path analyses!

@BEMColloquium @shell_ki The more adverse experiences you have as a child, the more physiological problems you tend to develop over the lifecourse.. exploring possible explanations

@BEMColloquium @shell_ki Michelle reminds us that ACEs have a social context.

@BEMColloquium @shell_ki Trying to understand if same shift seen elsewhere in the literature also exists here?

@BEMColloquium @shell_ki Allostatic load linked with biomarkers but what does that mean for outcomes we are actually interested in?

@BEMColloquium @shell_ki In age group below 55

@BEMColloquium @shell_ki CRP tracking together with CRP and other inflammation and CV biomarkers. Cortisol at the bottom.

@BEMColloquium @shell_ki Is this finding specific to this cohort? Thisb age range? Looking in a broader European context for insights...

@BEMColloquium @shell_ki (Not necessarily generalizable outside these populations)

@BEMColloquium @shell_ki

@BEMColloquium @shell_ki Hard to pin down what the exposures actually are.

@BEMColloquium @shell_ki Everything we do is somehow ultimately wrong... ;)

@BEMColloquium @shell_ki

@BEMColloquium @shell_ki So, given those limitations, how to we tackle social epi questions?

@BEMColloquium @shell_ki A need for triangulation

@BEMColloquium @shell_ki

Anyone who can bring it all back to Rudolf Virchow wins full points at the Charité ;) Thanks so much @shell_ki for the eye opening talk!