On 3/3/20 Chinese NHC issued version 7 of "Diagnosis and Treatment of Novel Coronavirus PNA" Info below
1. In confirmed cases (PCR) had serology with IgG/IgM
2. Most new have IgM + 3-5 days after onset
3. Recovery of IgG is 4 times or more higher than acute phase
1. In confirmed cases (PCR) had serology with IgG/IgM
2. Most new have IgM + 3-5 days after onset
3. Recovery of IgG is 4 times or more higher than acute phase
4. ECMO indications for Fi02 >90% and O2 index <80 mmHg for > 3 hrs, airway plateau pressure >35
5. CRRT for significantly ill patients
6. For severe and critically ill patients with elevated IL-6 and extensive lung disease recommend tocilizumab (ongoing trial in China)
5. CRRT for significantly ill patients
6. For severe and critically ill patients with elevated IL-6 and extensive lung disease recommend tocilizumab (ongoing trial in China)
7. #Tocilizumab does NOT prevent infix with #COVID19 it helps mediate the cytokine storm from IL-6
Some exclusion are ALT/AST > 5x ULN, active TB, or certain fungal infections
8. Children with severe or critical cases consider IVIG
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Some exclusion are ALT/AST > 5x ULN, active TB, or certain fungal infections
8. Children with severe or critical cases consider IVIG
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