Discover and read the best of Twitter Threads about #MERS

Most recents (24)

Seguimos en la parte más difícil de la pandemia y lo que sabemos hasta ahora sobre el #SARS_CoV2 y #Covid_19 va aumentando día con día. Recuerden que hace 5 meses no sabíamos mucho de este virus ni todo lo que puede ocasionar a nivel salud. Una pandemia lo cambia todo... Abro 🧵
1/La última pandemia devastadora fue la de influenza H1N1 en 1918 (gripe española) que mató a 20-40 millones en todo el mundo en un lapso de un año. El primer marido de mi bisabuela murió de esa gripe y le decía a mi abuela que había tantos muertos que los echaban a grandes fosas
2/En total al cabo de 2 años, se estima un total de casi 100millones de decesos, independientemente de aquellos por la 1era guerra mundial. En aquel tiempo, no había laboratorios seguros donde estudiar al virus, ni hospitales con el equipo de cuidados intensivos que ahora tenemos
Read 21 tweets
Mwanasayansi mwenye ubobezi wa kimataifa kwenye maswala ya vitendanishi na vipimo (Diagnostics), Dr. Ally Mahadhy, aliandika haya kwenye ukurasa wake wa facebook, ni vyema wadau humu wakayapata ili kuongeza uelewa @Udadisi
@MariaSTsehai @fatma_karume
#ElimikaWikiendi
Uzi 👇🏽
"Kutakucha tu!

Tukiwa tupo kwenye taharuki juu ya kipimo cha corona (covid-19) hapa nchini, baada kutoa majibu ya positive kwa mbuzi na papai, naomba nitoe maoni yangu kama mdau katika tansia hii ya vitendanishi vya maabara (diagnostics). ..." /1
Nianze kwa kutangaza maslahi yangu binafsi kwenye mada husika. Mimi ni mtafiti kwenye eneo hili la vitendanishi (Medical and clinical diagnostics). Tasnifu (thesis) yangu ya umahiri (MSc in Biotechnolgy) iljikita kwenye kutengeneza njia (method) ya kutambua kwa haraka na wepesi/2
Read 61 tweets
Mode vulgarisation:
Seconde partie de l'analyse initiée hier sur la publication portant sur la complexité de la pathologie inflammatoire du #COVIDー19.

@FZores @Le___Doc @Damkyan_Omega @fluidloading

Apres:
- hyperinflammation dans les cas sévères de COVID
- le rôle des macrophages/monocytes

passons aux 3 autres éléments clés:
- l'activation des macrophages
- l'hypercoagulation et l'activation du système phagocytaire mononucléaire (NMP)
- les cibles thérapeutiques possibles
L'activation des macrophages lors du SARS
La pneumopathologie SARS a déjà été identifiée comme la forme grave lors des épidémies précédentes de #MERS et #SARS_CoV1 (20% des patients). Comme pour le #SARS_CoV2 les macrophage infiltraient massivement les tissus.
Read 28 tweets
World Economic Forum: "Lockdown is the world's biggest #psychological #experiment - & we will pay the price"

Apr 9 2020 "With some 2.6 billion people around the world in some kind of #lockdown, we are conducting arguably the largest psychological experiment ever"

#Conditioning
"Unfortunately, we already have a good idea of its results. In late Feb 2020, right before EU countries mandated various forms of lockdowns, The Lancet published a review of 24 studies documenting the #psychological impact of quarantine."

#Handy
"The findings offer a glimpse of what is brewing in hundreds of millions of households around the world...

people who are #quarantined are very likely to develop a wide range of symptoms of #psychological #stress and #disorder..."

#Conditioning
Read 14 tweets
Let's talk about #COVID19 publications & #covardisation of the research. I have been following the literature last ~ 2 months & reviewed papers. I have a bit to say about it

Let's start first with 2 papers that came out today on #COVID19 and scholarly communication
---> Thread
First paper examines citations record, altmetric, social media... on early #COVID19 papers.
Out of 442 papers, only 26% primary studies => 21% -> basic science (too few) , rest clinical (case reports 42%)
Larger social media impact => high citations
medrxiv.org/content/10.110…
The 2nd paper examines wether #COVID19 has speed up #peerreview process
Answer is yes & peer review length has decreased by 1/2 due to reduce time for review
However trade off is publication quality is lower (e.g NEJM or CELL..)
This brings me to my point
biorxiv.org/content/10.110…
Read 13 tweets
Auf viel Interesse sind Prof Vogt's <Überlegungen eines besorgten Schweizer Bürgers> gestossen, ua die experimentelle Gemeinschaftsforschungsarbeit an synthetisch hergestellten #Corona-Viren (2015).

Sicherlich gibt es dazu weitere Fragen.
@derspiegel

mittellaendische.ch/2020/04/07/cov…
🔹Status, Zwischenergebnisse/berichte der #Corona-Gemeinschaftsforschung? Wird noch geforscht?
🔹Auftraggeber/Unis, Namen der Forscher? Inhaber des Labors in Bellinzona?
🔹1-jähriges Moratorium v/d US-Regierung der #MERS & #SARS Forschung wg Gefährlichkeit? Grund / Vorfall!?
Vogt’s Kommentare aus seinem #Corona-#Pandemie Bericht
[Zitat]
1. In 2015 wurde eine experimentelle Gemeinschaftsarbeit von Forschern aus drei US-Universitäten, #Wuhan und einem italienischen Forscher aus Varese, der in Bellinzona ein Labor hat, publiziert.
(1 v 3)
Read 6 tweets
#Covid19
Hilo sobre la mejora dependiente de anticuerpos (ADE).
Mientras se desarrollan vacunas, se trata a pacientes con plasma convaleciente y se considera pasaportes de inmunidad, primero entendamos el papel complejo de los anticuerpos en SARS , MERS y COVID19.
Los conejos infectados con MERS desarrollan respuestas de anticuerpos, pero no están protegidos tras el nuevo desafío y se observa una peor patología pulmonar. Transferencia pasiva de suero de conejo infectado a conejos sin Tto previo no protege y aumenta inflamación pulmonar.
Read 20 tweets
A thread on antibody-dependent enhancement (ADE) in #coronaviruses. While developing vaccines, treating patients with convalescent plasma, and considering immunity passports, we must first understand the complex role of antibodies in #SARS, #MERS and #COVID19. (1/13)
Rabbits infected with MERS develop antibody responses but are not protected upon rechallenge and worsened pulmonary pathology observed. Passive transfer of infected rabbit serum to naïve rabbits not protective and enhances lung inflammation. (2/13) ncbi.nlm.nih.gov/pmc/articles/P…
Analysis of 9 healthcare workers infected with MERS found most severe cases had highest anti-spike antibody titres. Three asymptomatic patients and one patient with mild disease had no detectable antibody response on the basis of ELISA and IFA. (3/13) ncbi.nlm.nih.gov/pmc/articles/P…
Read 13 tweets
Although related to the Severe Acute Respiratory Syndrome (#SARSCoV) & the Middle East Respiratory Syndrome (#MERS), #COVID19 virus #SARSCoV2 shows some peculiar pathogenetic, epidemiological & clinical features which have not been completely understood to date.
#SARSCoV2 is more phylogenetically related to #SARSCoV than to #MERS. Only minor differences have been found in the #genome sequences of SARS-CoV-2 comparing with SARS-CoV. SARS-CoV-2 affinity for angiotensin converting enzyme 2 (#ACE2) receptor is higher than in SARS-CoV.
Read 9 tweets
رشته توییت چهارم درباره #COVID19:

رشته توییت‌ها در توییتر:
1- bit.ly/2H2QpVj
2- bit.ly/3c6Kwog
3- bit.ly/2y3vKPn

رشته توییت‌ها در Thread Reader:
1- bit.ly/37TSFtv
2- bit.ly/2w3Vr1e
3- bit.ly/3akVHbs & bit.ly/3aknE3i Image
* ماسک آری یا خیر؟
* چگونه #2019_nCoV وارد بدن میشود؟
* کرونا ویروس چگونه در سلول میزبان همانندسازی میکند؟
* بعد از وارد شدن #2019_nCoV به بدن، چه اتفاقی برای بافتهای بدن میافتد؟
و...
در ادامه رشته توییت چهارم درباره #COVID19 و به دلیل اهمیت استفاده از ماسک، در ابتدا به توضیح
چرایی استفاده از ماسک پرداخته و در ادامه به سوالات مطرح شده در بالا و همچنین سوالات بیشتری پاسخ داده خواهد شد.

پس در ادامه این رشته توییت با من همراه باشید و در صورتی که آن را مفید یافتید برای دوستان خود ارسال کنید.
Read 104 tweets
#COVID19US
7 April 2020 Case Fatality Rate (CFR)

#Corrected
#COVID19US
7 April 2020 Case Fatality Rate (CFR)

Of concern, @CDC no longer reports confirmed/presumed (98.87%)

Cases:
((12,064 ÷ 374,329) x 100 ) = 3.22%

Daily CFR Δ: +0.53%

From 1 Dec 2019:

Vehicle Deaths: x̅14,592
COVID19 Deaths: 12,064
👉 cdc.gov/coronavirus/20…
Seasonal #CoronavirusUSA Case Fatality Rate:

((x̅54,064 ÷ x̅46,347,329) x100 ) =
x̅0.12%

Daily CFR Δ +x̅0.01%

From 1 Oct 2018:

Vehicle Deaths: x̅63,156
Flu Deaths: ≈54,064
👉 cdc.gov/flu/about/burd…
Read 5 tweets
#COVID19US
5 April 2020 Case Fatality Rate (CFR)

Of concern, @CDC no longer reports confirmed/pressumed.

Cases:
((7,616 ÷ 304,826 ) x 100 ) = 2.50%

Daily CFR Δ: + 0.006%

From 1 Dec 2019:

Vehicle Deaths: x̅14,364
COVID19 Deaths: 7,616
👉 cdc.gov/coronavirus/20…
Seasonal #CoronavirusUSA Case Fatality Rate:

((x̅49,616 ÷ x̅46,304,826) x100 ) =
x̅0.11%

Daily CFR Δ ±x̅0.00%

From 1 Oct 2018:

Vehicle Deaths: x̅62,928
Flu Deaths: ≈49,616
👉 cdc.gov/flu/about/burd…
Comparisons:

#MERS CFR = 34.4%
👉 who.int/emergencies/me…

#SARSCoV1 CFR = x̅17.55% (21.9% male; 13.2% female)
👉 pubmed.ncbi.nlm.nih.gov/14742282/

#SARSCoV2 CFR = 2.50%

Vehicle CFR = 1.12%
👉 iihs.org/topics/fatalit…

#COVID19UK CFR = 10.32%
Read 5 tweets
“If I get the #coronavirus, I’ll probably be OK.” said #MaxBrooks. “But if I give it to [my father, #MelBrooks], he could give it to #CarlReiner, who could give it to #DickVanDyke, & I’ve wiped out a whole generation of comedic legends."
deadline.com/2020/03/mel-br…
Why #PanicMongers like #Newsom, #Cuomo, #Fauci, & false accuser #MaxBrooks are full of ignorant crap when they blame #Trump for delaying mitigation of the spread of #SARSCoV2 virus.
npr.org/2020/03/24/820…
“The U.S. government relied on the Centers for Disease Control to produce a test; they failed ...
#CDC said they would handle it ...
Leaders at the CDC lied to both the HHS secretary and the president #Trump. And as a result the nation got weeks behind.”
fox11online.com/news/nation-wo…
Read 13 tweets
#COVID19US
4 April 2020 Case Fatality Rate (CFR)

Of concern, @CDC no longer reports confirmed/pressumed.

Cases:
((6,593 ÷ 277,205 ) x 100 ) = 2.39%

Daily CFR Δ: + 0.11%

From 1 Dec 2019:

Vehicle Deaths: x̅14,250
COVID19 Deaths: 6,539
👉cdc.gov/coronavirus/20…
#Perspective
Seasonal #CoronavirusUSA Case Fatality Rate:

((x̅48,593 ÷ x̅46,277,205) x100 ) =
x̅0.11%

Daily CFR Δ +x̅0.073%

From 1 Oct 2018:

Vehicle Deaths: x̅62,928
Flu Deaths: ≈48,593
👉cdc.gov/flu/about/burd…
#Perspective
Comparisons:

#MERS CFR = 34.4%
👉 who.int/emergencies/me…

#SARSCoV1 CFR = x̅17.55% (21.9% male; 13.2% female)
👉 pubmed.ncbi.nlm.nih.gov/14742282/

#SARSCoV2 CFR = 2.39%

Vehicle CFR = 1.12%
👉 iihs.org/topics/fatalit…
#Perspective

#COVID19UK CFR = 10.29%
👉
Read 5 tweets
#COVID19
3 April 2020 Case Fatality Rate (CFR)

Confirmed + assumed:
((5,443 ÷ 239,279 ) x 100 ) = 2.27%

Daily CFR Δ: + 0.09%

From 1 Dec 2019:

Vehicle Deaths: x̅14,136
COVID19 Deaths: 5,443
👉 cdc.gov/coronavirus/20…
#Perspective
Seasonal #CoronavirusUSA Case Fatality Rate:

((x̅47,443 ÷ x̅46,239,279) x100 ) =
x̅ 0.103%

Daily CFR Δ x̅ +0.073%

From 1 Oct 2018:

Vehicle Deaths: x̅ 62,814
Flu Deaths: ≈47,443
👉 cdc.gov/flu/about/burd…
#Perspective
Comparisons:

#MERS CFR = 34.4%
👉 who.int/emergencies/me…

#SARSCoV1 CFR = x̅17.55% (21.9% male; 13.2% female)
👉 pubmed.ncbi.nlm.nih.gov/14742282/

#SARSCoV2 CFR = 2.27%

Vehicle CFR = 1.12%
👉 iihs.org/topics/fatalit…
#Perspective
Read 5 tweets
#Corrected #COVID19 2 April 2020 Case Fatality Rate

Corrects computation error in Seasonal #CoronavirusUSA Case Fatality Rate (CFR) and Case Survivability Rate (CSR).
#COVID19
2 April 2020 Case Rates:

Confirmed + assumed:
((4,513 ÷ 213,144) x 100 ) = 2.18%

Daily CFR Δ: +0.24%

Daily CSR Δ: -0.24%

Since 1 Dec 2019:

Vehicle Deaths: x̅14,022
COVID19 Deaths: 4,513
👉 cdc.gov/coronavirus/20…
#Perspective
Seasonal #CoronavirusUSA Case Rates:

((x̅47,513 ÷ x̅46,213,144) x100 ) = x̅0.103%

CFR: x̅0.103%

CSR: x̅99.97%

From 1 Oct 2018:

Vehicle Deaths: x̅62,700
Flu Deaths: ≈47,513
👉 cdc.gov/flu/about/burd…
Read 6 tweets
There's still no proven treatment for Covid-19, but a number of trials are in the works. We don't know if any of them will show effectiveness against the novel coronavirus, but here are a few you might've heard of: (1/12)
Hydroxychloroquine and chloroquine. These related drugs are used to treat conditions like malaria and autoimmune diseases. (2/12)
There is limited evidence, partly from studies on human cells, that they could have antiviral effects -- one hypothesis being that they could make it harder for the novel coronavirus to enter human cells. (3/12) doi.org/10.7326/M20-12…
Read 12 tweets
Lessons from past #coronavirus & #influenza #epidemics suggest that #viral #infections can trigger acute coronary syndromes, arrhythmias, exacerbation of heart failure owing to a combination of a significant systemic inflammatory response plus localized vascular inflammation.
#COVID19 may either induce new cardiac pathologies &/or exacerbate underlying cardiovascular diseases. A large proportion of patients have underlying cardiovascular disease &/or cardiac risk factors. Factors associated with mortality include male sex, advanced age, comorbidities.
Acute cardiac injury determined by elevated high-sensitivity #troponin levels is commonly observed in severe #COVID19 cases & strongly associated with mortality. Acute respiratory distress syndrome is also strongly associated with mortality in patients with #SARSCoV2 infection
Read 6 tweets
Insights from #COVID19 @zoom_us
mtg w/ over 50 intl partners delivered by

Chief: Shao-Liang Chen @NanjingFirst
Prof. Ya-Ling Han
Dr Jun-Jie Zhang @jameszll1

#SBKCathLab
Chinese Society of Cardiology
196 countries have reported

#COVID19 (+) cases
Read 20 tweets
I just published C-19. Part One: The Chimera Protocol. It's not 100% ready but I feel like I'd better publish it before I fall asleep. They got to #stopscrewingup, seriously.

link.medium.com/WRAlIZr194
1/ Okay, since nobody appears to be interested, I'll just rehash points and timeline from my #Medium post about all pre- #COVID19 #research #US & #China did for "#pandemic preparedness". Proofs only, and if u think it's #fakenewscovid19, read the post and check out on the links.
2/
2009-2010: #H1N1 #SwineFlu #pandemic claimed "between 151,700 and 575,400 people" worldwide according to the CDC.

2011: Humanity generally stopped giving a f..k even though the #virus kept coming back.

Did the lesson go to waste? There was plenty of warning on #COVID2019.
Read 28 tweets
1. I feel the duty to help you to understand the debate on extremely intrusive #digitalSurveillance to fight #COVID. I don't feel comfortable to exclude such tracking in these days when thousands die, at the same time I have very serious concerns
2. we are now going through a situation we experienced after the 9/11 when politicians felt immense pressure. Interests to establish an #OrwellianSurveillance were also huge.Politicians opted for it (most shielded by secrecy) and that #OrwellianSurveillance is still here
3. It's very likely we will follow the same path:if we establish a new layer of extremely pervasive surveillance by putting together #HealthData,#localisation,#CreditCards,#phonecameras, it's very unlikely we will go back to the "old system".
Read 10 tweets
1.mi sento in dovere di aiutarvi a capire dibattito sulla creazione di strumenti tracciamento estremamente invasivi contro #COVID.Conosco questi temi in modo profondo e mentre non me la sento di demonizzarli in giorni in cui si muore come mosche,ne vedo tutti i pericoli
2. la situazione è simile a quella dopo l'11/9,dove la pressione a fare qualcosa per fermare rischio era immensa. Immensi erano anche gli interessi dietro la creazione di un sistema di sorveglianza Orwelliana, di cui NON ci siamo più liberati: è ancora qui, da 19 anni
3. andrà così anche con #COVID: se creeremo sistemi estremamente invasivi e capillari, NON ce ne libereremo più. Il sistema di sorveglianza #SudCorea è stato creato nel 2015 per #MERS: è ancora lì.
Read 9 tweets
हमारे शरीर में जब वायरस को लगता है शरीर उसके किसी काम का नहीं रहा तब वो दूसरा स्वस्थ्य शरीर ढूंढने लगता है.इस प्रक्रिया को कहते हैं शेडिंग. #CoronaVirus अपने symptoms दिखाने से पहले भी shedding कर सकता है.यानी symptom न दिखने पर संपर्क में आया व्यक्ति संक्रमित हो सकता है (1/7)
#CoronaVirus के संक्रमण को symptom में बदलने में 14 दिन का समय लगता है. लेकिन symptom दिखने के भी 20 दिन बाद तक ये वायरस शरीर में रह सकता है. यानी किसी के स्वस्थ्य हो जाने के बावजूद वायरस शरीर में हो ऐसा हो सकता है. (2/7)
#CoronaVirus से ज्यादा जानलेवा बीमारी थी #MERS पर वो #Pandemic क्यों नहीं बन पाई? क्योंकि MERS में वायरस हमारे RESPIRATORY TRACT में काफी नीचे जाकर बस जाता है. लेकिन #COVID19 ऊपरी हिस्से में ही रह जाता है जो खांसी या छींक के जरिए जल्दी बाहर निकलकर फैलने लगता है (3/7)
Read 7 tweets
@Thomasmarkelly @thehowie @DemFromCT I am opposed to widespread use of meds or med combos tested in only a small number of patients and in non-controlled trials. Rationale for these drugs is based, again, on small and non-randomized studies looking at HCQ for #MERS and macrolides for #Ebola and #Zika
@Thomasmarkelly @thehowie @DemFromCT There is some in vitro activity of chloroquines against #COVID19, but in vitro activity doesn’t always equate to in vivo
@Thomasmarkelly @thehowie @DemFromCT So far, based on these small cohorts, this drug combo has only been shown to reduce duration of symptoms, like Tamiflu does for influenza.
Read 5 tweets

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