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New preprint from @PasteurKorea

"In particular, two FDA-approved drugs – niclosamide and ciclesonide – were notable in some respects. These drugs will be tested in an appropriate animal model for their antiviral activities."

biorxiv.org/content/10.110…
Ciclesonide/Alvesco case reports from Japan.

Original: kansensho.or.jp/uploads/files/…

Machine Translation: writening.net/page?FC3QPm
Japan announces clinical trial
pj.jiho.jp/article/241752
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Phil Kerpen
@kerpen
We need random-sample serological testing as soon as possible.
wsj.com/articles/is-th…
We now have Stanford and Oxford teams saying there may be vast untested asymptomatic cases, which means all the projections we've been using are wrong.

Without representative sample serological testing we are making multi-trillion-dollar decisions in the dark.
And the observation by the authors that the closest thing to a broad sample tested population we have in the U.S. is the NBA is probably true -- and incredibly pathetic.
Read 3 tweets
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Phil Kerpen
@kerpen
We need a dramatically ramp up domestic HCQ production immediately.

Sanofi's supply is probably going to stay in France and with India using it for prophylaxis domestically I wouldn't count on exports from there.

Need domestic production of API and finished tablets ASAP.
Mylan and Teva have U.S. production but where are they sourcing API and how much do they have?

Where are all the generic manufacturers and where is their production going?

FDA clamping down on off-label use is NOT the solution to a supply shortage.

Produce more NOW.
Novartis/Sandoz announced a big *global* donation.

How much of it is coming to the U.S.?
Read 4 tweets
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Phil Kerpen
@kerpen
My dad's going to the ER, fever and trouble breathing. Please pray. His doc is @docshaymd.
Update: Admitted. Stable. PCU not ICU. Flu negative. Corona test sent out.
Still waiting on corona test results. They say it takes 3-4 days.
Read 3 tweets

Related threads

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Sam Modlin
@sam_modlin
(1/5) Encouraging pre-print out of Korea (though some important limitations to note): a collection of already FDA-approved drugs show strong efficacy against #Covid_19 in cell cultures. They highlighted two they found particularly promising: #niclosamide and #ciclesonide.
(2/5) ciclesonide PROS: 1. already been used on patients in Japan www3.nhk.or.jp/nhkworld/en/ne… 2. Appears specific to coronoavirus biorxiv.org/content/10.110… 3. Can be administered by inhalation
(3/5) #ciclesonide CONS: #MERS-CoV treated with ciclesonide developed resistance, upping the likelihood of resistance emerging in #SARSCoV2 SARS. I find this concerning because "pushing" the virus to evolve could drive its evolution down paths of greater mortality or infectivity
Read 5 tweets
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Bansi Sharma
@bansisharma
1. Nonsensical Liberal Brouhaha over "Immediate Availability" of Hydroxychloroquine for COVID-19

Allow me to explain how deranged this storm in a tea-cup attempt by liberals truly is, as they willfully try to miss the forest for the trees.
2. Technically, this MD friend of @ChrisJansing (possibly fictitious) is correct, but what the f*ck is s/he really livid about? His/her own willful ignorance! What does s/he think FDA's job is? FDA is not a papal organization that blesses and canonizes drugs in a ritualized way.
3. FDA approval is given based on the results of clinical trials that have been conducted in accordance with some rigorous, scientific rules. Every drug has to demonstrate sufficient safety and efficacy to be approved. That is the only way FDA is supposed to approve drugs.
Read 13 tweets
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Baba97
@Baba9773
1) News Roundup! Elijah Cummings, Wages Increasing, PDJT Tackles Prescription Drug Pricing, Governor DeSantis Got the Green Light, Democrats Are Pushing Against Americans When It Comes To Healthcare, China Is Playing Russian Roulette, Judicial Armada, Navy SEAL Eddie Gallagher,
2) Debate Thread, Rally Day.....

Our President tweeted this clip of Elijah Cummings admitting that Baltimore is a drug-infested area. This is so delicious!



Meanwhile the same POS said NO to Secretary Carson when invited by him to tour a HUD facility in
3) Baltimore.



From the article linked above:

Maryland Democratic Rep. Elijah Cummings declined an offer to tour a Baltimore Housing and Urban Development (HUD) facility with HUD secretary Ben Carson on Wednesday.

HUD invited Cummings to tour the
Read 47 tweets
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William J. Brady
@william__brady
New #preprint: we use range of psychological theory / data to develop a model to explain the spread of moralized content online via: motivation, attention and the design of social media (the MAD model). w/ @jayvanbavel @mollycrockett | psyarxiv.com/pz9g6 | summary below 1/6
We start by reviewing data suggesting that expressions of moral values and emotion spread rapidly during political discourse online. We examine how morality and emotion can spread online through social appraisal processes 2/6
What facilitates this ‘moral contagion’ online? We start with the *motivations*: from Social Identity Theory, we argue that moral-emotion expressions help uphold ingroup image. From partner choice theory, we argue that moral-emotion expressions can enhance our reputation. 3/6
Read 6 tweets
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Penny Midas Rollo
@PennyMidasRollo
001/ [article content in this tweet series 001-180 reproduced with permission from Martin Howe QC of Lawyers for Britain @lawyers4britain]
#quote "Leaving the EU on WTO terms: pulling down the barriers to world trade
Introduction: why prices will FALL after Brexit, not rise" /002
002/ #quote "Over the past couple of weeks, the media have been full of lurid scare stories about what will happen if the UK leaves the EU on WTO terms, because negotiations with the EU do not result in a withdrawal agreement." /003
#tariffs #NoDeal #Brexit #WTO #ProjectFear #shortages #food #medicines
003/ #quote "One of the most ridiculous and UNJUSTIFIED of these absurd scare stories is that it will lead to higher prices, and even shortages, of foods and medicines." /004
Read 180 tweets

Trending hashtags

#zero #supply #New #FDA #niclosamide #NEW #Profit #criminal #NoDeal #duty #SingleMarket #ACE2 #ProjectFear #budget #Strauss #production #food #TradeAgreements #ChequersPlan #trade #UkraineAirlinesCrash #subsidy #ThursdayThreads #ECJ #EUWithdrawalAct

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