Discover and read the best of Twitter Threads about #ace2

Most recents (24)

I have been busy the last two nights, had to organize my 3 by 5 cards

Granted, my handwriting is hard to read, even for me.
This is a preview of more on the way. 😉
- I made the 3 by 5 cards into a Power point style presentation - a first try 😉😊

audio/visual version last night, interview with @WeaponizedNews :: cmac.tv anchor.fm/weaponizednews *may not be up yet

Solutions for Chimeric Protein *new
dropbox.com/s/p484yvonbmt3…
Read 40 tweets
Potential Cause of COVID-19 ‘Long-haulers’ : antibodies specific for ACE2.

#ACE2
#LongCovid

"The antibody creates problems for the immune system by attacking the ACE2"

news.uams.edu/2021/09/09/uam…
"Patients with ACE2 antibodies have lower activity of soluble ACE2 in plasma. Plasma from these patients also inhibits exogenous ACE2 activity. ...

journals.plos.org/plosone/articl…
These findings are consistent with the hypothesis that ACE2 antibodies develop after SARS-CoV-2 infection and decrease ACE2 activity. This could lead to an increase in the abundance of Ang II, which
Read 7 tweets
Spike in My Veins

In this study we have made 4 important obs.: (i)Cardiovascular tissues and/or ENDOTHELIAL cells express the required genes for SARSCoV2 infection
(ii) SC2 receptor pathways, ACE2/TMPRSS2 and BSG/PPIB(A) POLARISE to lung/epithelium and vessel/endothelium>
respectively, (iii) expression of SC2 host genes are, on the whole, RELATIVELY STABLE WITH AGE and (iv) NOTABLE EXCEPTIONS were ACE2 which DECREASES with AGE in some tissues and BSG which INCREASES with AGE in ENDOTHELIAL CELLS...>
BSG is the DOMINATE PATHWAY used bySC2 in ECs...we are the FIRST to DEMONSTRATE a POSITIVE CORRELATION WITH AGE...BSG EXPRESSION IN THE VASCULATURE is a CRITICAL DRIVER which explains the heightened risk of severe disease and death observed in those >40yrs
Read 26 tweets
Wie #covid19 (vermutlich) impotent macht.

Sorry dass ich euch schon wieder damit behelligen muss, aber #Lümmelcovid ist dank Metal-Senior Bruce D. in den Medien, und so langsam sollte man das als reale Möglichkeit ernst nehmen.

Was steckt dahinter?
1/17
nme.com/news/music/iro…
Tatsächlich gibt es verschiedene Wege, auf denen Sars-CoV-2 die Erektion beeinträchtigen kann:
- Testosteronmangel
- Störung der Blutgerinnung
- Fehlregulation von Zellrezeptoren
- Infektion des Blutgefäßepithels
- psychische/sensorische Folgen der Krankheit
2/17
Bisher ist nicht klar, ob #Covid19 Erektionsstörungen wirklich häufiger macht. Das Problem ist, dass sexuelle Probleme allgemein schwer zu erforschen sind, weil Leute nicht gern drüber reden.
Die bisherige Studienlage hatte ich hier zusammengefasst:
3/17
scilogs.spektrum.de/fischblog/unfr…
Read 17 tweets
🤿Love is Like Oxygen🤿

Vents Harm Covid Patients & Make $ for Hospitals

Vents⬆️ACE2 which binds to and⬆️SC2
preprints.org/manuscript/202…
"But if it's COVID-19 pneumonia, then it's $13,000, and if that COVID-19 pneumonia patient ends up on a ventilator, it goes up to $39,000."
usatoday.com/story/news/fac…
Read 5 tweets
Will the newly identified sub-lineages of #Delta may initiate a new wave of #Covid19 in India? What impact the increasing prevalence of the Delta-D clade would have on global #COVID burden?

My write-up deliberating on these issues in @TheWireScience 👇 science.thewire.in/the-sciences/a…
#Delta variant and its extended family: How much do we need to worry?

During the first few months of the #pandemic, the evolution of the virus was relatively predictable, with substitutions accumulating at a fixed pace: 1 substitution every second week 2/
In contrast, the 2nd year of the #pandemic is punctuated by the emergence of several #variants that bore evidence of dramatic evolution 3/
Read 40 tweets
The receptors involved in SARS-CoV-2 infection are co-expressed in the cells of the NVU, especially in astrocytes and microglial cells. These receptors are functionally active as exposure of endothelial cells to the SARS CoV-2 S1 protein subunit ..
#HIV
#ACE2
#brain
altered the expression pattern of tight junction proteins, such as claudin-5 and ZO-1. Additionally, HIV-1 infection upregulated ACE2 and TMPRSS2 expression in brain astrocytes and microglia cells.
#astrocytes
#microglia
#brain
SC2 in BBB mechanism. Image
Read 10 tweets
Do children produce different types of #antibodies(Abs) against #SARSCoV2 than adults? 1/ Image
Yes, children mostly produced Abs aimed at #Spike protein, which the virus uses to enter cells. Adults generate similar Abs, but also develop Abs against the #Nucleocapsid protein, which is essential for viral replication 2/

pubmed.ncbi.nlm.nih.gov/33154590/
#Nucleocapsid protein is typically released in significant quantities only when a virus is widespread in the body.
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they aren’t experiencing widespread infection. 3/
Read 8 tweets
Can a respiratory #virus infection confer #immunity against the other #respiratory virus? A much-debated issue in the virus immunology for many decades. What is the probable immune mechanism & does it indeed exist? What is the evidence for & against this hypothesis? 1/
It is hypothesized that a respiratory virus infection confers immunity against the same and other respiratory viruses for a short time, perhaps a few weeks. This immunologic mechanism, known as #heterosubtypic ‘temporary non-specific immunity’ 2/
This immune protection is associated with activation of the innate immune response to viral infection mediated by the release of Type I #interferons (IFN) & other cytokines that have broad protective effects against a range of viruses 3/
Read 21 tweets
#InternationalBankingCartel Themes at 2021 G7 Meeting

#ClimateChange

+

#PublicHealth & the #ChinaVirus Outbreaks

+

Gender "Fluid" + LGBT + Anti-Testosterone (Strong, Aggressive White Men are Bad)

#EyesOpenFolks
#DemocratCorruptionNetworks
Where have All the Cowboys Gone ?

Read 20 tweets
We know that the two Ad-vector based vaccines, #AstraZeneca & #JNJ lead to clot-related complications like cerebral venous sinus thrombosis. We also know these events are referred to as ‘Vaccine induced Thrombotic Thrombocytopenia’ (VITT). But what lead to these complications? 1/
Now a new explanation for VITT seen with vector vaccines. “Vaccine-Induced #Covid19 Mimicry” Syndrome: Splice reactions within the #SARSCoV2 Spike ORF result in ‘Spike protein variants’ that may cause thromboembolic events in patients immunized with vector-based vaccines 2/
These soluble Spike #variants may initiate severe side effects when binding to #ACE2-expressing #endothelial cells in blood vessels 3/
Read 27 tweets
#ChinaVirus

#Infertility (Temporary?)

the infection of the human testis with SARS-CoV-2 may impair male germ cell development, leading to germ cell loss and higher immune cell infiltration

ncbi.nlm.nih.gov/pmc/articles/P…
hmmm....
#ACE2 Receptors

Impact on Testosterone and Male Infertility remains poorly understood, but theoretical risks would make the Virus Profile attractive to certain players in the game

academic.oup.com/biolreprod/art…
Read 10 tweets
⚠️"If you remove the replicating capabilities of the #coronavirus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this #ACE2 receptor, the S protein receptor, now famous thanks to #COVID19."-Uri Manor Image
Read 3 tweets
In the latest issue! Be sure to explore this exciting research about #SARSCoV2 variants and their #escape from #immune response
bit.ly/3e2QxoP

For all @CellPressNews #coronavirus research and commentary, visit cell.com/2019-nCOV
#COVID19
🔽🔽🔽
Mutations in the #SARSCoV2 spike #protein result in tighter binding to the #ACE2 receptor and allow escape from monoclonal #antibody neutralization. Online now! @UniofOxford
bit.ly/3nzukSI
The 501Y.V2 #variant of #SARSCoV2 exhibits resistance to neutralization from monoclonal #antibodies and sera from convalescent as well as #immunized individuals
bit.ly/3xxMrNe
Read 5 tweets
#LongCovid bei Kindern
Eine Zusammenfassung von Studien und Meldungen:
Klinische Merkmale, Aktivitätsniveaus und psychische Gesundheitsprobleme bei #Kindern mit LongCovid
Die bislang umfangreichste Studie über #LongCovid von 510 betroffenen #Kindern: Clinical Characteristics, Activity Levels and Mental Health Problems in #Children with Long COVID: A Survey of 510 Children
#LongCovid in England: Bericht über #Kinder die nach milden COVID-Verläufen unter #Atemnot, #Gelenkschmerzen und #Schwindel leiden. Das chronische Erschöpfungssyndrom ist bei einigen so stark, dass sie auf einen #Rollstuhl angewiesen sind #twlz #kmk
bbc.com/news/uk-englan…
Read 77 tweets
Infektionsgefahr in #Schulen über belastete #Aerosole
Professor #Kähler schließt sich der #AITAsk Bewertung an:
"#Lüften alleine reicht nicht. Die Schulen wurden ja lange zugemacht, weil es eben nicht reicht". #twlz #kmk #rki
sueddeutsche.de/muenchen/landk…
Schulen sind mittlerweile wieder geöffnet, weitere Jahrgänge sollen folgen, dabei steigen bundesweit die Infektionszahlen. Gleichzeitig breitet sich die Mutante #B117 weiter aus. #Schulen sollen "eher" keine Pandemie-Treiber und dank #AHA+L sicher sein, sagt das #RKI. Stimmt das?
Eine erste Warnung, was ein #Superspreader im #Klassenzimmer bewirken kann und warum #Schulen sehr schnell zu einem Pandemie-Treiber werden können, zeigte das Ergebnis der #AITask-#Modellierung bereits im August 2020: Superspreader Klassenzimmer #twlz #kmk
Read 135 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
Der Kampf um R– ich möchte einmal versuchen darzustellen, wie bei einer Epi-/#Pandemie letztlich dieser eine Wert „R“ bestimmt, ob und wie sich die Infektion ausbreitet und wie beide Seiten– Mensch *und* Virus– versuchen, R zu ihren jeweiligen Gunsten zu verschieben! #COVID19
1️⃣/
Jeder, der mit dem Virus infiziert kann es theoretisch auf jemand anderen übertragen und damit zur Verbreitung beitragen. Bei wem das zu welchem Zeitpunkt wie wahrscheinlich ist, hängt von vielen Faktoren ab. Ganz klar: die Menge an „lebensfähigem“ Virus in den oberen…
2️⃣/
Atemwegen ist maßgeblich für die Möglichkeit, jemand anderen anzustecken, was aktuell nun auch in einer großen Studie gezeigt wurde⬇️. Die sog. Viruslast ist bei #SARSCoV2 übrigens bereits kurz (~1d) *vor* Einsetzen der Symptome sehr hoch, wodurch dieser Zeitraum um den…
3️⃣/
Read 26 tweets
#Cassandra: #SARS1 bound "Spikes" to Human #ACE2 receptors ONLY. Those are rare in healthy people.

In #SARS2 & #MUTANTS (#COVID19) they now bind ALSO to #Furin receptors, as in #HIV/#AIDS & #Ebola, which makes it 1000 x as #Infectuous:

— RT World News rt.com/news/481837-co…
#Cassandra: January 2020 article:

Uncanny similarity of 4 unique #Inserts in the 2019-nCoV (SARS-CoV-2) spike protein to #HIV1 (AIDS) #Gp120 and #Gag:

->biorxiv.org/content/10.110…
#Cassandra: Article March 2020.

#SARS_CoV_2 (COVID19) is NOT Natural !

#Czech molecular biologist, Dr. Soňa Peková explains in layman terms that #COVID19 virus originates from a lab, and the Americans try to refute it (Updated):

dimsumdaily.hk/czech-molecula… via @dimsum Daily
Read 10 tweets
Hello la communauté ! J’ai fait un résumé des #vaccins contre le #SARSCoV2 pour la famille. Si ça vous intéresse de vous informer à propos de la stratégie de #VACCINATIONCOVID, je pose ça là. Petit thread de vulgarisation, c’est parti ! #VaccinCovid
Pour rappel, le virus #SARSCoV2 c’est ça. La protéine #Spike est la porte d’entrée du virus dans nos cellules en reconnaissant la protéine #ACE2 à la surface de nos cellules. C’est la cible principale des vaccins.
L’objectif du vaccin est de booster notre réponse immunitaire contre le virus et les cellules infectées. Les stratégies diffèrent selon les vaccins, on va le voir bientôt.
Read 22 tweets
Sobre la nueva mutación del virus del #SARSCOV2 les dejo un breve hilo explicando con palabras claras e información disponible las consecuencias y las implicaciones de esta nueva mutación
1/10
Todo nace por q el Reino Unido secuencia casi el 10% de todas las muestras q procesa, en Diciembre, ellos vieron un aumento en los casos de #COVID19 y tambien vieron q el árbol filogenético mostraba secuencias virales distintas a las antes vistas medium.com/swlh/variants-… 2/10
Se sabe q el SARS-CoV-2 muta bastante, hasta ahora, la tasa de mutación viral es de +/- 1 a 2 por mes. O sea, el #SARSCoV2 de hoy difiere en alrededor de 20 puntos (geneticos) del virus en relación al secuenciado en China en Enero del 2020, por ende,sabemos q el virus muta 3/10
Read 12 tweets

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