....will be seen in #COVID – Why? Massive use of Propofol. While Green Urine is Benign, effects of prolonged over-sedation & immobilization ++ #DELIRIUM are not 😤 Wake them up & get out of bed. Start w/SAT…#A2Fbundle & #PICS
1/ re: SATs to avoid over-sedation in #COVID19 pts, Thx @phanton_icu for Protocol Blindness caution & @Nitkjain reminder “Easier said than done.” I’ve been pondering your comments all day & think them ripe for further conversation on #A2Fbundle
2/ Remember, protocols like #A2Fbundle are guides & not “1-shoe-fits-all pts.” Correct, we must deviate when needed. However, these 6 principles (ABCDEF) are derived from 35 NEJM, JAMA, Lancet papers +400 others & now >25,000 pts of data. Not chump change. bit.ly/2JwVA4E
3/ #COVID pts are quantatively different in ARDS/shock, yes (eg, LONG illness), but NOT qualitatively different. We should NOT throw out these safety principles. No. We have to adjust but not abandon. Our COVID-D study of 2,100 pts will be out in Lancet RM in a few weeks.
4/ COVID-D absolutely upholds that more deviation from our tried & true approaches yields a heavy burden of suffering in our patients, including ⬆️ death. Stay tuned. Let’s all work together to learn. Now, another word on Protocol Blindness…
5/ In my own practice. I have found “anecdote blindness” a MUCH bigger problem. This occurs when I act on a series of anecdotes to the detriment of my other pts by abandoning solid evidence of a better way. This happened in the MIDST of the ABC Study and it almost cost us...
6/ In our ABC Lancet study, nurses thought SAT/SBT protocol wasn’t working & wanted to abandon. Turned out despite their anecdotal opinions in APACHE=26 pts that halving benzos/propofol/fent saved lives. COVID-D suggest same thing ~15 years later.
7/fin So what am I saying? Yes, our #COVID19 pts are suffering immensely & getting historically heavy doses of sedation coupled w evil amounts of isolation from family + #delirium. What to do? EVERY time the sun comes up, we must try rehumanization again via #A2Fbundle
Trigger alert 🚨: Hard to stomach but this hits so hard I want to face it. Segregation of Blood🩸by color of skin went on until 1972 & the “1-drop rule” persisted until 1983 in my home state of LA. 😩 👀 labels.
I pledge to fight #racism & lift each person.
1/ Dr. Charles Drew, an African-American surgeon & father of blood banking, perfected techniques that saved countless lives. Yet he was prohibited from donating blood himself over “fear” of his black blood. Read #2 w/ ✍🏻 bit.ly/2IRvJDW #MedTwitter#MedStudentTwitter
2/ Dr. Drew ✍🏻 this letter of protest because he wasn’t being allowed to🩸: “I think the Army made a grievous mistake, a stupid error in first issuing an order to the effect that blood for the Army should not be received from Negroes. My 3 reasons are...”
Especially at EOL, ICU #Diary is part of #A2Fbundle. My pt w/ home-hospice told me details recorded in #ICU by #nurse allowed her to decipher cryptic #delirium memories she was struggling with.
2/ Then she told me of hours spent reading big-hearted comments others had written in her ICU diary, making her realize how much her life meant to others. It was a priceless gift to her at a critical juncture in what had a time of deep poverty in her life. #PalliativeCare
3/ ICU Diaries give family members at bedside a practical way of helping w/ loved one’s care & can help channel their worries in a focused way. #criticalcare#pulmcc
“On Friday, the magnolia tree next to the #covid tent bursts into riotous blossom despite the chilly weather. Until now, the flowers have been delicate cups of pink and lavender, spaced along the spindly gray branches...”
(She shared pic...)
3/ Dr. Ofri continues...
“Now they’ve abruptly reversed their concavity, spilling open into an unbroken blanket of defiant white.
Normally, the inner workings of the hospital are invisible to doctors and nurses. We show up every day and the patients are there, the beds...”
1/ When I play the #criticalcare movie 🎥 of me as an intern or resident back in my head, I see myself as much too robotic 🤖 with my patients, as if plugging in kitchen appliances.
2/ The nurse would slip a Foley catheter up his urethra into his bladder. I’d go to the stockroom to get all the materials to slide a plastic endotracheal tube down his trachea to become command-central for his breathing on the ventilator.
3/ Next, I’d methodically place a Swan-Ganz catheter by serial insertion of a needle first, then a wire through the needle, next a dilator over the wire, and finally the catheter itself down into his great vessels and heart. And start the ‘pressors.
1/ In #COVID19, we must learn from #BRAIN masters Engel & Romano, who described #DELIRIUM to #DEMENTIA relationship in the 1950s! Here are my TOP 10 CLASSIC quotes from their famous 1959 article: bit.ly/2SePA1a
2/ The problem of delirium is far from an academic one. Not only does the presence of #delirium often complicate and render more difficult the treatment of a serious illness, but also it carries the serious possibility of permanent irreversible brain damage.
1/ There are clinically relevant differences between #COVID19#Sepsis & typical bacterial sepsis, but they are Quantitative rather than Qualitative. That is, all clinicians have seen them before in other sepsis pts before this #virus 🦠 infected its 1st human.
2/ Quantitative septic findings are more commonly part of daily care for #COVID patients than we have been used eg, near total loss of the tracheobronchial tree’s muco-ciliary escalator due to destruction of ciliated respiratory epithelium.
3/ Classically in #Influenza pneumonia/sepsis, this predisposes to subsequent superinfection from bacteria like Staph & Strep. In #COVID, we are always on the ready to begin antibiotics to cover such complications of what initially was a pure viral infection.