Let’s shift our focus from Spike to #Nucleocapsid protein!
A new study demonstrates that genetic mutations outside the Spike are also key components in #SARS2 continued adaptation to human infection.
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A new study demonstrates that genetic mutations outside the Spike are also key components in #SARS2 continued adaptation to human infection.
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The #R203K-#G204R mutation is sufficient to enhance replication, fitness, & pathogenesis of #SARS2. Importantly, the R203K-G204R mutation increases #nucleocapsid phosphorylation, providing a molecular basis for these phenotypes.
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Notably, an analogous #alanine substitution mutant also increases #SARS2 fitness and phosphorylation, suggesting that infection is enhanced through ablation of the ancestral ‘RG’ motif. A new Preprint by @TheMenacheryLab 👇
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biorxiv.org/content/10.110…
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biorxiv.org/content/10.110…
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