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me64 陳美滿 Profile picture
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2 Nov, 5 tweets, 3 min read
Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2
ORF3a Transmembrane Protein

#Orf3a #SARSCoV2
#mAbs
1/n
 mdpi.com/1999-4915/13/1…
- SC2 ORF3a is a putative viral ion channel implicated in autophagy inhibition, inflammasome activation and apoptosis, is involved in virus replication and release. 4/n
covidcg.org/?tab=report
Orf3a mutations are highly shown in delta & it's lineages and beta var & gamma var.

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More from @mega_pindang71

me64 陳美滿 Profile picture
2 Nov
The vaccinated🐶🐶developed autoantibodies to many of their own biochemicals,➡️the vac 🐶🐶 were attacking their own fibronectin, which is involved in tissue repair, cell multiplication & growth, etc.

Thanks @impressionist81 🙏
dogsnaturallymagazine.com/purdue-vaccina…
The fact that vaccines and adjuvants can trigger a pathogenic autoimmune response is corroborated by animal models. The use of animal models has enabled the study of the effects of application of
pubmed.ncbi.nlm.nih.gov/27417999/
adjuvants in a homogeneous population with certain genetic backgrounds. In some cases, adjuvants may trigger generalized autoimmune response, resulting in multiple auto-antibodies, but sometimes they can reproduce human autoimmune diseases including rheumatoid arthritis,
Read 4 tweets
me64 陳美滿 Profile picture
2 Nov
Comparison of SARS-CoV-2 Receptors Expression in Primary Endothelial Cells and Retinoic Acid-Differentiated Human Neuronal Cells
#TMPRSS2 #NRP1 #ACE2 levels increase when cells are treated with #retinoicacid (RA).
#ACE2 and #TMPRSS2 expression in subsets of lung epithelial cells
are regulated by androgen-signaling. #NRP1 is highly expressed in the respiratory and olfactory epithelium, which can explain the SC2 infectivity and spreading through both the lungs and olfactory bulb. NRP1 is involved in axonal guidance and pruning. Data indicate that
pseudoviral entry is aligned with the expression of NRP1 levels. This seems to substantiate the previous observations showing that NRP1 plays a major role for SARS-CoV-2 entry in certain cell types. Here, the study demonstrated higher expression of both NRP1 and TMPRSS2,
Read 6 tweets
me64 陳美滿 Profile picture
2 Nov
High SARS-CoV-2 seroprevalence in persons experiencing homelessness and shelter workers from a day-shelter in São Paulo, Brazil
. 1/n

#covid in #homelessness ppl & #shelter #workers #Brazil

journals.plos.org/plosntds/artic…
Serum samples, nasopharyngeal and oropharyngeal swabs of persons who are homeless and shelter workers collected from August 25th-27th, 2020 were tested for the presence of anti-SC2 IgM and IgG antibodies by ELISA and SARS-CoV-2 RNA by RT-qPCR, respectively. 2/n
All swab samples tested negative by RT-qPCR.
Seropositivity in homeless ppl IgM 5/203 (2.5%) and IgG 111/203 (54.7%)
and in shelter workers IgM 5/87 (5.7%) and IgG 41/87 (47.1%).
3/n
Read 6 tweets
me64 陳美滿 Profile picture
16 Oct
Potential Cause of COVID-19 ‘Long-haulers’ : antibodies specific for ACE2.

#ACE2
#LongCovid

"The antibody creates problems for the immune system by attacking the ACE2"

news.uams.edu/2021/09/09/uam…
"Patients with ACE2 antibodies have lower activity of soluble ACE2 in plasma. Plasma from these patients also inhibits exogenous ACE2 activity. ...

journals.plos.org/plosone/articl…
These findings are consistent with the hypothesis that ACE2 antibodies develop after SARS-CoV-2 infection and decrease ACE2 activity. This could lead to an increase in the abundance of Ang II, which
Read 7 tweets
me64 陳美滿 Profile picture
1 Oct
Ivermectin 0.2-0.4mg/kg works at the outer and inner part of cells, thru P2X, GlycineCls, has anti-inflammatory effects, proven for decades, etc.
Molnupiravir 800mg twice a day for 5 days, works thru the RdRp. Can this antiviral have the side effects similar to Remdesivir ?
Comparison studies about Molnupiravir.
Gordon et al. : the high frequencies of G-to-A and C-to-U transition mutations in coronaviruses exposed to molnupiravir.

#host DNA #mutagenesis possibility

nature.com/articles/s4159…
Kabinger et al. entertains A-to-G transitions, which can occur in coronaviruses exposed to molnupiravir, albeit at much lower frequencies.

Thus, although the biochemical evidence indicates that molnupiravir triphosphate (MTP)
is a better CTP (natural nucleotide) analog, the ..
Read 5 tweets
me64 陳美滿 Profile picture
29 Sep
Variant that could potentially affect more people who are vaccinated against COVID-19.
#Vaccine creates #variants

#Nsp12 #W152L #C241U Mutations

Also found in all VOCs #P323L and #D614G mutations.

"What Is the R.1 COVID-19 Variant? What We Know So Far" health.com/condition/infe…
Orf9c
N proteins
Read 5 tweets

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