Thread by @mega_pindang71

Comparison of SARS-CoV-2 Receptors Expression in Primary Endothelial Cells and Retinoic Acid-Differentiated Human Neuronal Cells
#TMPRSS2 #NRP1 #ACE2 levels increase when cells are treated with #retinoicacid (RA).
#ACE2 and #TMPRSS2 expression in subsets of lung epithelial cells

are regulated by androgen-signaling. #NRP1 is highly expressed in the respiratory and olfactory epithelium, which can explain the SC2 infectivity and spreading through both the lungs and olfactory bulb. NRP1 is involved in axonal guidance and pruning. Data indicate that

pseudoviral entry is aligned with the expression of NRP1 levels. This seems to substantiate the previous observations showing that NRP1 plays a major role for SARS-CoV-2 entry in certain cell types. Here, the study demonstrated higher expression of both NRP1 and TMPRSS2,

and a slight increase of ACE2 in RA-differentiated neuronal cells. This, in turn, allowed for the binding of the Spike protein, with subsequent increased fusion and entry into the differentiated neuronal cells as compared to the undifferentiated cells.

Emerging VOI and VOC could result in different viral infection capabilities and functional dysregulation of particular subsets of neuronal cell populations.
mdpi.com/1999-4915/13/1…

Endothelial Related Genes Regulated by RA.
@selfcarerocks
@impressionist81

journals.plos.org/plosone/articl…