Some imp insights into #omicron by Dr Jacob John , 🧵@naveenthacker & @vipintukur
🚨Probably #Delta plus 🦠 is t last major mutation that occurred at human level
🚨Delta plus caused syncytia formation in 🫁 that resulted in multinucleated cell which incited more damage of 🫁
3.this mutant is going to remain for ⬆️ period & in turn may be an endemic 🦠 .
4. Newborns may not hv immunity like influenza 🦠 & ‘may’ req regular 💉 .
5.#Omicron is not a variant (probably) but a deviant. In t sense it is antigenic shift , probably derived frm infected 🐀
🚨the mutations in #OmicronVariant mimicked that of 🐀 antigen .
🚨#omicron pathology is not like syncytia but like endocytosis
🚨hence t damage is insignificant and will not affect alveoli and hence no hypoxia, lung damage
🚨⬆️affinity to pharynx , leading to throat pain.
🚨🦠 is more in saliva &!hence throat swabbing technique is better here.
🚨Keep t swab for 30 secs in 👄 cavity to absorb more 🦠 to get omicron positivity.
🚨usual immunity against delta (or alpha) may not work here .but as the pathogenecity is less , it may not be worrying
🚨omicron is of 2 types.
🚨monoclonal Ab now available in India will not work against omicron.
🚨finally #COVID19 may end up with 2 types of 🦠 circulating -delta plus & Omicron
15.this will change t vaccine composition in the near future just like with flu #vaccine .

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More from @vikkypaedia

26 Nov 21
Such a well written editorial this in @Open_HeartBMJ Superb..!!…
a must read for everyone... #MedTwitter #Cardiology
interesting points a 🧵👇
Metabolic acidosis is a chronic condition that
many people in the Western world have but
do not realize it... It occurs when there is
retention of acid in the body, which leads to
a depletion in the bicarbonate stores of the
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what are the Four main mechanisms that compensate for chronic latent metabolic acidosis?
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26 Nov 21… a superb article with many many learning points..#neurotwitter #MedTwitter #AcademicTwitter #scicomm
key points in the review article "Localization in focal epilepsy"👇
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26 Nov 21
B.1.1.529 seems to have gone from 0.1% to 50% in just a couple of weeks, when it took Delta several months to achieve that..!!

Brace up folks..!!

Things are getting worrisome folks..!! Read and understand this thread..!!
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25 Nov 21
#Covid outbreak in SDM Med college, Dharwad, #Karnataka after a student college festival.. many infected… @MoHFW_INDIA @DHFWKA @ICMRDELHI #news
Yesterday Day 1
URTI like symptoms !
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All stable till now..!!
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Residual #SARS-CoV-2 🦠 ags detected in GI and liver tissues from 5 recovered pts with #COVID-19.… @vipintukur @AskDrShashank @VirusesImmunity
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Although resp transmission is responsible for most COVID-19 inf, there is ⬆️ evidence of COVID-19 causing GI & hepatic manifestations, as studies reported the presence positive SARS-CoV-2 RNA in anal swabs & stool samples, despite NP or sputum specimens testing -ve for the virus
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Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier.. @vipintukur @ProfSomashekhar @naveenthacker @iapindia @INDIANJOURNALO4 @VirusesImmunity @EditorIndPed @ICMRDELHI @MoHFW_INDIA @iiscbangalore Image
Weeks after #SARS-CoV-2 inf or exposure, some children develop a severe, life-threatening illness called Multisystem Inflammatory Syndrome in Children (#MIS-C). GI symptoms are common in MIS-C pts & severe hyperinflammatory response ensues with potential for ❤️ complications.
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