Some imp insights into #omicron by Dr Jacob John , 🧵@naveenthacker & @vipintukur
🚨Probably #Delta plus 🦠 is t last major mutation that occurred at human level
🚨Delta plus caused syncytia formation in 🫁 that resulted in multinucleated cell which incited more damage of 🫁
3.this mutant is going to remain for ⬆️ period & in turn may be an endemic 🦠 . 4. Newborns may not hv immunity like influenza 🦠 & ‘may’ req regular 💉 .
5.#Omicron is not a variant (probably) but a deviant. In t sense it is antigenic shift , probably derived frm infected 🐀
🚨the mutations in #OmicronVariant mimicked that of 🐀 antigen .
🚨#omicron pathology is not like syncytia but like endocytosis
🚨hence t damage is insignificant and will not affect alveoli and hence no hypoxia, lung damage
🚨⬆️affinity to pharynx , leading to throat pain.
🚨🦠 is more in saliva &!hence throat swabbing technique is better here.
🚨Keep t swab for 30 secs in 👄 cavity to absorb more 🦠 to get omicron positivity.
🚨usual immunity against delta (or alpha) may not work here .but as the pathogenecity is less , it may not be worrying
🚨omicron is of 2 types.
🚨monoclonal Ab now available in India will not work against omicron.
🚨finally #COVID19 may end up with 2 types of 🦠 circulating -delta plus & Omicron
15.this will change t vaccine composition in the near future just like with flu #vaccine .
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Metabolic acidosis is a chronic condition that
many people in the Western world have but
do not realize it... It occurs when there is
retention of acid in the body, which leads to
a depletion in the bicarbonate stores of the
body. Ways to test for low-grade metabolic acidosis👇
what are the Four main mechanisms that compensate for chronic latent metabolic acidosis?
This is such a fantastic Summary of semiological signs by symptomatogenic zone on mesial and lateral structures. DLPFC, dorsolateral prefrontal cortex; SMA, supplementary motor area.
#SARS-CoV-2 nucleocapsid protein (NP) was detected in the colon, appendix, ileum, haemorrhoid, liver, gall- bladder and lymph nodes from 5 pts who recovered from COVID-19, ranging from 9 to 180 days after testing -ve for SARS-CoV-2. #MedTwitter
Although resp transmission is responsible for most COVID-19 inf, there is ⬆️ evidence of COVID-19 causing GI & hepatic manifestations, as studies reported the presence positive SARS-CoV-2 RNA in anal swabs & stool samples, despite NP or sputum specimens testing -ve for the virus
Weeks after #SARS-CoV-2 inf or exposure, some children develop a severe, life-threatening illness called Multisystem Inflammatory Syndrome in Children (#MIS-C). GI symptoms are common in MIS-C pts & severe hyperinflammatory response ensues with potential for ❤️ complications.
👉🏽As proof of concept, they treated a #MIS-C patient with #larazotide, a #zonulin antagonist, & monitored impact on antigenemia and clinical response.
👉🏽in MIS-C, prolonged + of SARS-CoV-2 in t GI tract ➡️ to release of zonulin, a biomarker of intestinal permeability,