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Dr Sudhir Kumar MD DM🇮🇳 Profile picture
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Jan 26 • 9 tweets • 3 min read
Daily coffee consumption is good for chronic liver disease patients

1. Coffee is a popular beverage & is known to have multiple health-related benefits including better overall survival in several diseases. A systematic review looked at association of coffee and #liver disease.
2. Coffee consumption was associated with improved serum gamma glutamyl transferase (GGT), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values in a dose dependent manner in individuals at risk for liver disease.
#MedTwitter
3. In chronic liver disease patients who consume coffee, a decreased risk of progression to cirrhosis, a lowered death rate in cirrhosis patients, and a lowered rate of hepatocellular carcinoma (liver cancer) development were observed.
4. In chronic hepatitis C patients, coffee was associated with improved virologic responses to antiviral therapy.
Moreover, coffee consumption was inversely related to the severity of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD).
5. Daily coffee consumption should be encouraged in patients with chronic liver disease.
Reference
doi.org/10.1111/liv.12…
6. Higher coffee consumption is inversely associated with the severity of hepatic fibrosis in individuals with NAFLD.
doi.org/10.3390/nu1307…
7. Moderate coffee consumption has beneficial effects on various liver diseases, possibly by inhibiting adenosine binding to its receptors.
doi.org/10.3389/fphar.…
8. Caffeine inhibits hepatic stellate cell activation by blocking adenosine receptors.
Caffeine favorably impacts angiogenesis and hepatic hemodynamics.
Chlorogenic acids (phenolic component of coffee) suppress liver fibrogenesis and carcinogenesis
doi.org/10.3390/nu9010…
9. Take home message
Coffee consumption has favorable effects on liver diseases and people suffering from liver diseases should be encourage to consume coffee on daily basis.

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More from @hyderabaddoctor

Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Jan 27
Does habitual #Coffee consumption increase the blood pressure (BP)?

1. Coffee is the most widely consumed drink (after water) and coffee lovers need clarity whether it is safe in all aspects. Does it raise the BP? Is coffee safe for people with hypertension (high BP)? Let us see
2. No added risk of high BP
The results of numerous studies and meta-analyses indicate that "moderate and habitual coffee consumption does not increase" and may even reduce the risk of developing arterial #hypertension.
doi.org/10.1007/s11906…
3. Coffee can be safely consumed by people with high BP
Moderate "habitual coffee consumption in hypertensive persons does not increase the risk of uncontrolled blood pressure" and may even reduce the risk of death from any cause.
Read 10 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Jan 27
HbA1c screening in adults can significantly reduce the time to diabetes diagnosis

1. HbA1C (glycosylated hemoglobin) is a marker of average plasma glucose during the previous 8-12 weeks.
An HbA1c of 6.5% is recommended as the cut point for diagnosing #diabetes.
#MedTwitter
2. In a recent population-based study in UK, HbA1c screening in adults aged 40–70 years reduced the time to diabetes diagnosis by a median of 2.2 years compared with routine clinical care. link.springer.com/article/10.100…
3. Highlights of the study Image
Read 5 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Jan 27
Sudden Cardiac Arrest (SCA) during Sports Activity in Older adults

1. We occasionally hear about apparently healthy people collapsing and dying while running, cycling or working out at gym.
A recent study looked at the prevalence of sports-related SCA in people aged >65 years.
2. Salient findings of the study and their implications
#gym #running #fitness #sports #cardiacarrest
#MedTwitter #CardioTwitter Image
3. Of 4,078 SCAs among people ≥65 years of age, 77 were Sports-related SCA (1.9%; 91% men).
The annual Sport-related SCA incidence among ≥65 years was 3.3/100,000 in Portland and 2.1/100,000 in Ventura. The most common associated activities were cycling, gym, and running.
Read 4 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Jan 26
The darker side of dark chocolates

1. Dark chocolates are popular due to their potential health benefits (they are rich in anti-oxidants and are good for heart) and moreover, they are low in sugar content. >50% consider them as safer and healthier option (as compared to candies)
2. But there’s a dark side to this “healthier” #chocolate. Research has found that some dark chocolate bars contain cadmium and lead—two heavy metals linked to a host of health problems.
Consumer report scientists detected cadmium & lead in many dark chocolate samples tested.
3. Consistent, long-term exposure to even small amounts of heavy metals can lead to a variety of #Health problems. The danger is greatest for #pregnantwomen and young #Children because the metals can cause developmental problems, affect #brain development, and lead to lower IQ.
Read 8 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Jan 26
1. Replacing just 9 minutes (per day) of sedentary behavior (SB) by moderate-vigorous #PhysicalActivity (MVPA) results in better #cognition scores over long-term in middle aged people.
MVPA time was derived using a step cadence of ≥100
#exercise #dementia
dx.doi.org/10.1136/jech-2…
2. Possible physiological explanations underlying a direct role for MVPA in supporting cognition include *Acute increases in cerebral perfusion,
*Growth factor release such as brain-derived neurotrophic factor,
*Hippocampal neurogenesis.
3. Lastly, MVPA, when attained by structured exercise, involves some degree of self-motivation, planning and social interaction, which are all factors considered to be cognitively stimulating.
Read 5 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Jan 25
Canadian guidance on #alcohol consumption
(January 2023)
1. Young people should delay alcohol use for as long as possible.

2. Individuals should not start to use alcohol or increase their alcohol use for health benefits.

3. Any reduction in alcohol use is beneficial.
4. When pregnant or trying to get pregnant, no amount of alcohol is safe
5. When breastfeeding, not drinking is safest
6. Consuming no drinks is associated with better health & better sleep,
7. Three to six drinks/week raise the risk of developing breast, colon & other cancers
8. Seven or more drinks per week increase the risk of #heart disease or #stroke.

9. Each additional drink "radically increases" the risk of these health consequences.

10. Consuming one or two standard drinks weekly will likely not have alcohol-related consequences.
Read 4 tweets

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