Discover and read the best of Twitter Threads about #Toxoplasma

Most recents (7)

[CASE REPORT] Brain biopsy detects #Bartonella in brain lesions: A 28-year-old woman presented to the neurology department with progressive vision loss in both eyes over the prior four months (continued in comments). #Lyme #Lymedisease
1/5 She had a history of #lupus and had been on high-dose prednisone. A brain MRI showed numerous lesions in her cerebral and cerebellar hemispheres.
2/5 A brain biopsy was performed, and Bartonella henselae was discovered. Antibiotics were started, her vision improved, and the lesions resolved.
Read 6 tweets
Here at @BSPparasitology, I will be live-tweeting today from the Veterinary Parasitology session at Appleton Hall 2 & from 11:30 am-13:00 PM, from the Protists 5 session: Genomics & Evolution at McEwan Hall! So I will retweet from parallel sessions! Beautiful #BSP2023 final day! Image
Beginning #BSP2023 Day 4 and opening our Veterinary Parasitology session today, is Dr Lynsey Melville (taking over from Fiona Kenyon) of @MoredunComms who is telling us about "Making #roundworm data ewe-niversal for all". #parasitology Image
Dr Melville of @MoredunComms tells us about her research in monitoring the development of anthelmintic resistance in the treatment of gastrointestinal nematodes in sheep, particularly focusing on Nematodirus battus resistance to benzimidazoles:… #BSP2023
Read 38 tweets
Very pleased to present our recent study of #endocytosis in #apicomplexans that draws on #K13 and drug-resistance in #malaria to learn of a highly unusual endocytic machinery in #Toxoplasma with a deep evolutionary origin.…
Using the #Plasmodium #artemisinin-resistance genes as initial leads, some proximity proteomics, and a good deal of super-res microscopy, a comprehensive molecular model of endocytic pits integrated into the cell’s complex (IMC) pellicle was achieved.
Remarkably, this superstructure is highly stable with the typically ephemeral proteins rigidly anchored at this site. Even more unusual, the complex is preassembled in daughter cells before the plasma membrane is even recruited. (and yes, Toxo daughter cells ARE gorgeous!)
Read 12 tweets
𝟭𝟵𝟴𝟬:Wojciech “Al” Krotoski et al publish a report in the British Medical Journal describing a dormant liver stage of #Plasmodium cynomolgi in Rhesus macaques. These dormant liver stages, called "hypnozoites" are postulated to be the cause of relapses of this #malaria species Image
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𝟭𝟵𝟴𝟭: In 1981, Dr William C. Campbell of the Merck Institute for Therapeutic Research in the US, published "An Introduction to the Avermectins" which described a new series of compounds with potent antiparasitic properties against nematode & arthropod #parasites. Image
Read 88 tweets
𝟭𝟵𝟳𝟬: It was in 1970 that the full life cycle of #Toxoplasma gondii was described for the 1st time by Frenkel et al. Nowadays, the micro- and macro- gametocyte stages in the cat intestine are rarely studied, so the Frenkel et al. (1970) micrographs are still informative. Image
𝟭𝟵𝟳𝟭: A year that would forever change the field of #malaria research. In 1971, Prof Youyou Tu of the China Academy of Chinese Medical Sciences in Beijing, would use ether to extract "qinghaosu" from Artemisia annua L. leaf extract. In English: Artemisinin. @womeninmalaria Image
Read 7 tweets
In 𝟭𝟵𝟲𝟲, the eminent parasitologist P. Cyril C. Garnham published his "magnum opus", the 1132-page encyclopaedia of #malaria parasites, "Malaria Parasites and Other Haemosporidia". After 56 yrs, images from this book are still used as references across the world. #Plasmodium Image
𝟭𝟵𝟲𝟳- what a year! In 1967, Ruth Nussenzweig & colleagues released a @Nature paper showing that X-irradiated Plasmodium sporozoites produced protective immunity against #malaria in mice. This study sparked research that would result in the identification of CSP (1/3) Image
Read 11 tweets
@MBVanElzakker and I are excited that our new paper on biological factors that may contribute to the development of LongCovid/PASC was published today:…
2/ The paper details mechanisms by which RNA #viruses beyond just #SARS-CoV-2 have be connected to long-term health consequences.
3/ It also reviews literature on acute #COVID-19 and other virus-initiated chronic syndromes such as post-#Ebola syndrome or #ME/CFS to discuss different scenarios for #LongCovid/#PASC symptom development.
Read 10 tweets

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