1/ Little Thread about all The Misleading Medical Information still floating around about #Hydroxychloroquine & #Chloroquine & #Azithromycin & #ZelenkoProtocol - by 1 doctor - @zev_dr & #Remdesivir & more
Despite #TrumpIsNotADoctor has stopped saying "What do you have to lose?".
2/ #TrumpIsTheWORSTPresidentEVER
First, why it has been political all the way, suspected from day one:
"Trump had been touting HCQ for weeks, sparking worldwide shortages of HCQ & prompting negotiations with Indian PM Modi to lift export restrictions"
vanityfair.com/news/2020/04/i…
3/ #Trump2020
Indian PM Modi and Trump held a rally together.
"Mr Trump wanted to show people in the US that he was hugely popular abroad and that he was capable of negotiating good deals out of a country he once described as the king of tariffs"
bbc.com/news/world-sou…
4/ #Hydroxychloroquine & #Azithromycin
The largest *Multicenter trial* was done in Albany, NY. *600 patients in 22 hospitals*
"Acquired 70K Doses of Hydroxychloroquine, 10K doses of Zithromax & 750K Doses of Chloroquine"
👇
governor.ny.gov/news/amid-ongo…
👇
nypost.com/2020/04/23/hyd…
👇
5/ #Hydroxychloroquine & #Azithromycin
Why go out with this when it's not been peer-reviewed yet? It is obviously a heads-up.
"It's been tried this on virus after virus & it never works out in humans. Dose needed is just TOO HIGH, Science Magazine"
theguardian.com/science/2020/m…
6/ Again #Hydroxychloroquine & #Azithromycin
"Around 30 patients with symptoms of #COVID19 had reported serious side effects of heart disorders after taking HCQ, Martin told AFP. Also warned against other drugs such as the antibiotic Azithromycin"
euronews.com/2020/04/02/fra…
7/ Only #Hydroxychloroquine
"Hospitals in Sweden have stopped using the malaria drug on #COVID19 patients after reports it was causing blinding headaches & vision loss"
Confused? Surely they used HCQ, as CQ is not on the market in Norway or Denmark.
dailymail.co.uk/news/article-8…
8/ #Chloroquine
Brazil researchers planned to enroll 440 people in a double-blind study testing chloroquine against #COVID19
"Findings suggest that *higher CQ dosage* (10 days) should not be recommended for COVID19"
Why try high dose? See 5.
medrxiv.org/content/10.110…
9/ #Hydroxychloroquine & #Azithromycin
"A panel of experts convened by NIH recommends against doctors using a combination of HCQ and AZ for the treatment of COVID19, as associated with QTc prolongation in COVID19 patients"
This is NOT just #DrFauci !
npr.org/sections/coron…
10/ #Azithromycin, #Chloroquine, #Favipiravir, #Hydroxychloroquine #Lopinavir / #Ritonavir & #Remdesivir
"Estimators of LQTS risk levels indicated a very high or high risk for all COVID-19 repurposed drugs"
Not AZ, but "cases of TdP have been reported"
medrxiv.org/content/10.110…
11/ #ZelenkoProtocol only brings Zinc to the table, in addition to HCQ & AZ. Based on this study, which does *not* mention Coronaviruses at all, as published in 2004. In study *IN VITRO* is mentioned 8 times, while *IN VIVO* is mentioned just 1 time.
ncbi.nlm.nih.gov/pmc/articles/P…
12/ #ZelenkoProtocol
On April 30th @zev_dr tweeted:
Gateway Pundit, which is entirely political & stupid, ref @sickendun2death
Links to IlTempo, in Italian, which links to the study. Conclusion before "ACKNOWLEDGEMENT".
👇
onlinelibrary.wiley.com/doi/epdf/10.10…
👇
13/ #Trump2020 & his reason for advertising #Hydroxychloroquine
#Trump & his allies used this study to advertise the use of HCQ
👇
mediterranee-infection.com/hydroxychloroq…
👇
International Society of Antimicrobial Chemotherapy RETRACTED the study already April 3rd!
👇
14/ #Remdesivir
Remdesivir has gotten a lot of press lately.
"The mortality rate for the remdesivir group was 8%, compared to 11.6% for the placebo group; that mortality difference was NOT statistically significant"
Its Legal Status = Investigational.
statnews.com/2020/04/29/gil…
15/ #Resist #Resisters #Resistance
Still searching #Hydroxychloroquine #Chloroquine ?
"Medicines Agency cannot authorise hydroxychloroquine for COVID-19 if the company manufacturing the medicine does not apply for an authorisation"
#BigPharma = Scared
laegemiddelstyrelsen.dk/en/news/2020/c…
16/ Feel free to join in and retweet if you want to.
@PhunPhraud @TCSReservations @sickendun2death @FcQuarantine @KelsieLeeDavis @RoicephusP @WarlockWoods @beenjammin8486 @FredrikHirsch @stenhalle @dad_darius @RandomFSM
Cheers 🍻
17/ #ZelenkoProtocol
@zev_dr Triple-Links so you don't find the actual source: In Tweet 12.
Of 6 hospitalized, only 3 received suppos. spec.
treatment for COVID-19:
1 got #Hydroxychloroquine
1 got HCQ + #ritonavir / #darunavir
1 got HCQ + #anakinra
18/ #TrumpIsTheWORSTPresidentEVER
#Hydroxychloroquine & #Azithromycin & #Cardiology
"Patients hospitalized & receiving HCQ for COVID-19 frequently *experienced QTc prolongation & ADEs, including a case of torsades de pointes* with admin. of HCQ and AZ"
jamanetwork.com/journals/jamac…
19/ #Hydroxychloroquine & #COVID19
"200 mg daily for 3 days followed by a maintained dose of 800 mg daily for remaining days (2/3 weeks - mild/moderate/severe). HCQ did not result in a significantly higher negative conversion probability than SOC alone"
medrxiv.org/content/10.110…
20/ #Hydroxychloroquine #TrumpMeltdown #NewYork
"1376 patients during a median follow-up of 22.5 days. 811 received HCQ. 600 mg twice on day 1 then 400 mg daily for a median of 5 days. 45.8% of the patients were treated within 24 & 85.9% within 48 hours"
nejm.org/doi/full/10.10…
21/ #ZelenkoProtocol
1. Abstract Conclusion = Zinc helps
2. But: Paragraph 2 under METHODS
3. Essential to read study's methods
"Patients were *included* if ... had either been discharged from the hospital, transitioned to hospice or expired"
Full PDF:
drive.google.com/file/d/1XkIHqV…
22/ #Hydroxychloroquine & #Chloroquine & #Azithromycin
Norwegian Medicines Agency published a Warning April 23 & updated it on May 6.
Translates perfectly to English:
bit.ly/3fBSN5b
Citations:
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
#TrumpLiesAmericansDie
23/ #Remdesivir & #Vaccines & #SARSCoV2 & #COVID19
Norwegian Medicines Agency reports:
"Investigations started in Europe"
EMA - Remdesivir:
ema.europa.eu/en/news/ema-st…
NMA - Medicines & Vaccines:
legemiddelverket.no/english/covid-…
#TrumpPressConf #TrumpLiesAmericansDie
24/ #COVID19 #SARS_CoV_2
Number 4 out.
"1438 in #NYC - Compared with Patients receiving Neither, Cardiac Arrest was Significantly more Likely in Patients Getting #Hydroxychloroquine & #Azithromycin - To our knowledge; largest report of adverse effects"
jamanetwork.com/journals/jama/…
25/ #Hydroxychloroquine & #Azithromycin
Comparison: In Study 2 the 119 HCQ/AZ group.
nature.com/articles/s4159…
"Patients with #COVID19 treated with HCQ/AZ, QTc was significantly prolonged"
ahajournals.org/doi/10.1161/CI…
Lacks doses: "QTc prolongation. Seldomly needed to discontinue"
26/ #Hydroxychloroquine #TrumpIsALaughingStock
"Eficacy data & the irrefutable clinical data collected through the #COVID19 Global Rheumatology Alliance registry establish that #Lupus patients on baseline therapy with HCQ are NOT universally protected"
ard.bmj.com/content/early/…
27/ #SARSCoV2 #COVID19 #TrumpGate #TrumpLiesAmericansDie
DMA has Up-to-Date lists of Ongoing Trials of Vaccines & Medicines.
Significants in Yellow = Design can potentially provide important knowledge.
Vaccines: laegemiddelstyrelsen.dk/da/nyheder/tem…
Medicines: laegemiddelstyrelsen.dk/da/nyheder/tem…
28/ #MentalHealthAwareness
Feeling down because of the lack of truly effective Therapeutics and Vaccines?
Maybe this beautiful song is one to add to your playlist?
Full version as MP3 here: drive.google.com/file/d/1bDjdhl…
29/ #Hydroxychloroquine #Chloroquine #Azithromycin
"A widespread misconception that EUA means FDA-approved, driven by certain irresponsible politicians and members of the media", Kesselheim, Prof. of Medicine, Harvard
FULL: bit.ly/3dY6TvZ
TWP: wapo.st/3fXcSDk
30/ #TrumpHasNoPlan
Now that #Trump claims he's taking #Hydroxychloroquine - here is a Timeline.
Full PDF: bit.ly/3bKyP5g
Source: washingtonpost.com/politics/2020/…
31/ #TrumpHasNoPlan
Since all the Side Effects of #Hydroxychloroquine & #Azithromycin are never mentioned in the press, usually just the cardiovascular ones, documented well above, here are both lists. From the European & Norwegian Medicines Agency SPCs
👇 + 👇
32/ #Hydroxychloroquine
"What do you have to lose? Take it!"
- Trump, April 4
Didn't want to add this.
But now #Trump criticizes the VA Study b/c they were "old & sick" - as if only with negative outcome.
Median age = 69
Trump:
* Old (73)
* Obese
* Hearth disease
👇 + 👇
33/ #Hydroxychloroquine & #Azithromycin
Perspective: Number 32.
Deaths / Age
1. HCQ group: 27.8% / 70yr
2. HCQ + AZ group: 22.1% / 68yr
3. Control Group: 11.4% / 69yr
Risk groups.
*All ages* in USA as of now:
(92058 ÷ 1534064) × 100 = 6%
Full PDF: bit.ly/2zQhrPc
34/ #Hydroxychloroquine & #Chloroquine & #TrumpVirus
"WHO epidemiologist: Largest single-day increase in Coronavirus Cases"
Live page, so search for "Largest single-day increase" in the page itself.
cnn.it/3bSrCAf
Interestingly the Sharpest Rise in (H)CQ Trio
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35/ #ZelenkoProtocol & #Hydroxychloroquine
See Number 21 first.
Didn't even know confirmed administration.
"Cohorts were identified based on medications *ordered rather than confirmed administration*, which may bias findings towards favoring equipoise between the 2 groups"
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36/ #SARSCoV2 & #COVID19
The meta-analysis of treatment with #Hydroxychloroquine or #Chloroquine with/without a #Macrolide published in The Lancet May 22 was retracted June 5.
A NEJM article too. It was not about medical treatment.
Same obvious reason:
thelancet.com/journals/lance…
37/ #SARSCoV2 & #COVID19
2 Major Studies cited by press that didn't use Surgisphere's DB at all & studied #Hydroxychloroquine and/or #Azithromycin
1. Number 20 (NEJM)
2. Number 24 (JAMA Network)
More needed, so:
HCQ is back in WHO's Solidarity Trial: who.int/emergencies/di…
38/ #SARSCoV2 & #COVID19
June 15:
"FDA revokes Emergency Use (EUA) of #Hydroxychloroquine and #Chloroquine … As of the date of this letter, the oral formulations of HCQ and CQ are no longer authorized by FDA to treat COVID-19"
First 2 pages explains:
drive.google.com/file/d/1vEDT5y…
39/ #Hydroxychloroquine
Solidarity Trial was resumed after Number 36.
#COVID19 treatment stopped b/c of:
* UK Recovery Trial
* French Discovery Trial
* Solidarity Trial itself
* Cochrane Review
But not for pre/post-exposure prophylaxis.
Since link in Number 37 is updated
👇
40/ #COVID19
Part of UK Recovery Trial in Number 39.
Corticosteroids are commonly used in ICUs based on clinical evaluation.
Based on 2,104 randomized *very sick*, #Dexamethasone is "first drug to be shown to improve survival", Prof. Horby.
Read both:
drive.google.com/file/d/1yyrhZG…
41/ #COVID19
Trial design:
* 176 hospital orgs.
* 28-day mortality
* Randomized
* 4321: Usual care
* 2104: #Dexamethasone
Reduced deaths:
* 1/3: Invasive ventilator
* 1/5: Oxygen only
Of 6, #Hydroxychloroquine was stopped, ref Number 40.
PRELIMINARY:
drive.google.com/file/d/1-nkmVT…
42/ #TrumpFailedAmerica
Published July 16:
#Hydroxychloroquine in Nonhospitalized Adults With Early #COVID19
* Randomized
* Double-blind
* Placebo-controlled
HCQ did not substantially reduce symptom severity in outpatients with early, mild COVID-19
acpjournals.org/doi/10.7326/M2…
43/ #Hydroxychloroquine #Lopinavir #Ritonavir #ZelenkoProtocol #TrumpLiedPeopleDied
From July, but the results of this Big & Multinacional Trial belong in this Thread.
Content has been continuously updated, so picture of current text attached.
Source: who.int/emergencies/di…
44/ #COVID19 #Pfizer #Pfizervaccine
First let us empathize that the so-called "Pfizer Vaccine" is developed by German BioNTech.
90% Efficiency *is promising*, but Self-Reported, and from just 94 Cases:
* < 10% in Vaccine Group
* > 90% in Placebo Group
cnn.com/2020/11/09/hea…
45/ #Covid_19 #BidenTransition
Follow-up:
«Pfizer didn't accept Federal Funding, unlike front-runners Moderna & AstraZeneca (UK-SE) … has distanced itself from Trump & Operation Warp Speed» [NYT].
Deep Refrigeration at -70°C [-94°F] needed - Moderna's too.
The limit, so
👇
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