Profile picture
Richard Riley @Richard_D_Riley
, 4 tweets, 3 min read Read on Twitter
NEW: Minimum sample size for developing a multivariable prediction model PART II: binary & time‐to‐event outcomes. Big thanks to @GSCollins @f2harrell @Kym_Snell @CarlMoons @DanielleBurke88 @joie_ensor Calculate minimum EPV required based on three criteria onlinelibrary.wiley.com/doi/full/10.10…
Our aim: push researchers to develop robust prediction models Thus the sample size should be large enough to minimise overfitting, whilst precisely estimating key parameters (e.g. overall risk). Complements work by @MaartenvSmeden that suggests the 10 EPV rule is, well, dead.
Note that in many situations we need more than 10 EPV ... but in our paper, there is an example where lower is acceptable. Depends on setting (outcome proportion / prevalence / rate) and anticipated model performance.
Our proposal allows us to tailor EPV to setting and model at hand, rather than relying on a blanket rule of thumb for every scenario
Missing some Tweet in this thread?
You can try to force a refresh.

Like this thread? Get email updates or save it to PDF!

Subscribe to Richard Riley
Profile picture

Get real-time email alerts when new unrolls are available from this author!

This content may be removed anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member and get exclusive features!

Premium member ($30.00/year)

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!