Thread by @ogi_gajic

1/ #ClinicalResearch Primer
A personal hands-on experince:
You’re interested in causes of ARDS & transfusion comes up. Literature review=many ?s: Is it the reason for transfusion or transfusion itself? Is it just fluid? Is it RBC or plasma. Is it “storage lesion” or antibodies?

2/ You dig deeper and find some fascinating studies largely known only by transfusion specialists:
ncbi.nlm.nih.gov/pubmed/4071603
ncbi.nlm.nih.gov/pubmed/11960539
You get your feet wet in a retrospective cohort study using a standardized definition (for the first time) ncbi.nlm.nih.gov/pubmed/16965572

3/ You learn it is plasma rather than red cells:
ncbi.nlm.nih.gov/pubmed/17400669
ncbi.nlm.nih.gov/pubmed/16276195
and the storage duration (fresh vs old) does not matter:
ncbi.nlm.nih.gov/pubmed/22281833

4/ A “natural experiment” gives additional weight to the implications of female donor plasma
ncbi.nlm.nih.gov/pubmed/17522583
Further proof comes from both surveying the number of pregnancies & antibody concentrations in plasma given to those who developed ARDS
ncbi.nlm.nih.gov/pubmed/17626910

5/ The findings are confirmed in the multicenter study
ncbi.nlm.nih.gov/pubmed/22117051
where you also have a chance to evaluate the results of male predominant plasma policy change
you helped promote ncbi.nlm.nih.gov/pubmed/17671245

6/ To help with rational use of transfusions you design and evaluate minimally disruptive informatics tools
ncbi.nlm.nih.gov/pubmed/16691136
ncbi.nlm.nih.gov/pubmed/17236185
As the burden of TRALI lessens, you move on to other causes of ARDS...
ncbi.nlm.nih.gov/m/pubmed/20802…