, 24 tweets, 21 min read
Follow along as we live tweet the @FertStert journal club. What do you think about #uterinetransplant? #ASRM2019
Send your questions via Twitter to ask the panel! #ASRM2019
#uterine transplant is a treatment for absolute uterine factor infertility #ASRM2019
Largest cohort of #uterinetransplant recipients: Swedish trial with 7 surgically successful transplants (recipients started menstruating). #EmbryoTransfer performed 12 months after transplant. Thus far, 8 babies born. #ASRM2019
Multidisciplinary team including #gynecologists, reproductive medicine, obstetricians, transplant medicine, #psychologists and #ethics cared for the donors and recipients enrolled in the trial. #ASRM2019
Criticisms of early #uterinetransplant was lack of oversight. Trials in Sweden and @ClevelandClinic changed this paradigm with data safety monitoring boards and ethics committees. #ASRM2019
@ClevelandClinic Prior to #uterinetransplant in humans, 15 years of research in animal models performed in Sweden. #translationalresearch #ASRM2019
@ClevelandClinic The first surgeries for #uterinetransplant lasted 10-13 hours for removing the uterus and 4 hours to transplant. #ASRM2019
@ClevelandClinic Surgeries are faster now, and Baylor has done their last 5 transplants using #robotic surgery. Will this be the best route going forward? #ASRM2019
@ClevelandClinic With a living #donor, you must consider the risk- helping one person but potentially harming the donor. #ASRM2019
@ClevelandClinic Using a #deceased donor negates the donor risk, but screening may be incomplete. The next of kin may not know health history including abnormal pap tests, obstetric history. This could impact the #recipient. #ASRM2019
@ClevelandClinic Do you think living or deceased donor models are best for #uterinetransplant?
@ClevelandClinic Right now demand in the #USA appears to be exceeding the supply of centers with ongoing trials. Dr. Flyckt notes we have an "epidemic of women with hysterectomy" #ASRM2019
@ClevelandClinic Cost estimates for #uterinetransplant for donor and recipient in #USA ranges from $200,000 - 1 million. In #Sweden, charges are covered by government and are estimated to be $60,000. #ASRM2019
@ClevelandClinic We know the #uterus does NOT age in terms of receptivity. Many donors are the mothers of #uterinetransplant recipients. #ASRM2019
@ClevelandClinic If a #uterinetransplant occurs, should we only implant a #euploid embryo? #ASRM2019
@ClevelandClinic Baylor requires #euploid embryos to enter #uterinetransplant trial. @Penn, @ClevelandClinic and University of Gothenburg in #Sweden do NOT require PGT-A. #ASRM2019
@ClevelandClinic @Penn Dr. De Ziegler suggests we perform all #embryotransfer after #uterinetransplant in a natural cycle. Recent studies suggest risk of #preeclampsia is lower with a corpus luteum. #ASRM2019
@ClevelandClinic @Penn Dr. Flyckt cautions that we should not have "conversations on women and what they can and cannot do with their bodies among a group that does not include these women" #ASRM2019
@ClevelandClinic @Penn Arguments FOR #uterinetransplant include choice, privacy, and control. Read this @elliottrichards paper to hear from women who have uterine factor infertility. #ASRM2019

@ClevelandClinic @Penn @elliottrichards Arguments against #uterinetransplant: concern for prolonged immune suppression, epigenetic changes, risks of the procedure may not be known until we do several thousand cases
@ClevelandClinic @Penn @elliottrichards Dr. Kate O'Neill advocates for increasing #choice. Provide the patient with information about all options (adoption, gestational carrier, #uterinetransplant) and let them make an informed decision. #ASRM2019
@ClevelandClinic @Penn @elliottrichards Tell us what you think! Let's continue the conversation on #uterinetransplant! Thanks to Interactive Associate @dremilybarnard for this recap. #ASRM2019
Missing some Tweet in this thread?
You can try to force a refresh.

Like this thread? Get email updates or save it to PDF!

Subscribe to Fertility Sterility
Profile picture

Get real-time email alerts when new unrolls are available from this author!

This content may be removed anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Follow Us on Twitter!

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!