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Jennifer Doudna calls for stronger "countermeasures" against CRISPR babies. (thread)
science.sciencemag.org/content/366/64…
She seems to be talking about legal countermeasures---regulations to control gene-editing human embryos.

But in her lab, she works on literal countermeasures, that is, molecular antidotes to genome editing. Here's that story from a little while back. technologyreview.com/s/613309/the-s…
Last time Jennifer Doudna said gene-editing needs regulations some legislators in California passed the first CRISPR law, targeting biohackers. technologyreview.com/s/614100/dont-…
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Antonio Regalado
@antonioregalado
Veritas Genetics which tried to make a business offering inexpensive whole genome sequencing to consumers, is going out of business in the U.S., looks like.

Had problems including a data breach and just a lack of demand from people to know their genes.
"Veritas in July said that it had sequenced 5,000 genomes, with a goal of sequencing more than 150,000 in 2021. The company has raised more than $50 million in venture funding, according to Crunchbase."

From story last month reporting the databreach. bloomberg.com/news/articles/…
In 2017 we reported Veritas going to offer whole genome sequencing for Chinese kids, but planned offerings to that market -- predictions about baldness, musical talent -- were condemned by expert opinion here.

The china baby plan was quickly cancelled

technologyreview.com/s/608086/baby-…
Read 8 tweets
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Antonio Regalado
@antonioregalado
What do you think? Should the complete text, including scientific data, of He Jiankui's manuscripts about the CRISPR babies manuscripts become public?
further reasons that didnt fit in the poll

Pro release:
-demonstrate that direct embryo editing still not reliable
-stop next He
-defy Chinese state censorship of affair

anti release:
-research incomplete
-leave it to the authors
-no peer review
In the accompanying item, @kiranmusunuru argues why the information should be public. technologyreview.com/s/614762/crisp…
Read 3 tweets
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Antonio Regalado
@antonioregalado
Scientists debate. Should He Jiankui's draft manuscripts be released in full?

In favor: Let everyone see it, understand it, learn more about it.

Against: Unethical human subjects research, must be repressed.
Howard Bauchner, the editor of JAMA, which reviewed but rejected the manuscript, told me this was the "central quandry."

“If someone thinks it’s scientifically valid but not ethical, does that mean the study will stay in the shadows?"

technologyreview.com/s/614761/natur…
What do you think? Take the poll

Read 3 tweets

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Eric Topol
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97% of #cancer drugs tested fail. Why?
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Hakim Abdi, PhD
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Gretchen Goldman, PhD
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Macroscopyroli 🔥
@Helixis_Felis
#Thread

Bonjour, c’est moi, Jean-Michel La Mort du Fun et aujourd’hui on va parler d’un des facteurs de la possible extinction future des #amphibiens (la classe d’organismes qui comprend les grenouilles, les crapauds, les salamandres, les tritons et les céciles) :D
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En 2004 une 1ere évaluation révélait que 32% des espèces étaient globalement menacées, au moins 43% connaissaient une forme de diminution de la population et qu'entre 9 et 122 espèces avaient disparu depuis 1980. (science.sciencemag.org/content/306/57…)
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Gaetan Burgio
@GaetanBurgio
Finally the comments to Mitalipov’s group paper on #CRISPR in human embryos are out in @nature as well as the rebuttal from Ma et al. as brief communications arising #paywall. Let’s have a look more in details -> Thread
One of the major finding of the Ma et al. paper was the discovery of high frequency of inter-homologous repair mechanisms aka loss of heterozygocity LOH -> 1 allele is used as a template for
#CRISPR-HDR -> WT alleles are in fact alleles from the maternal alleles only.
We have been debating a lot on this in the last year or so. The first important comment from @Fatwa_Adikusuma et al is Ma et al. missed deleted alleles. In the paper they edited 6 loci in zygotes and EScells and checked for large deletions nature.com/articles/s4158…
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Lluis Montoliu
@LluisMontoliu
Hace una semana lanzé un HILO en el que explicaba los orígenes e información básica para entender las herramientas #CRISPR. Gracias a @jm_alarcon ese HILO está recogido en esta web: threadreaderapp.com/thread/9834491… Hoy continuaré con otro en el que hablaré de las aplicaciones. Dentro HILO
Las herramientas #CRISPR nos han cambiado tanto la vida a los investigadores de ciencias de la vida que prácticamente suelo decir que pronto solamente habrá dos tipos de laboratorio: (1) los que YA están usando CRISPR en sus experimentos y (2) los que VAN a usar CRISPR. Y ya está
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