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Eric Topol
@EricTopol
, 3 tweets, 6 min read Read on Twitter
97% of #cancer drugs tested fail. Why?
When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR @CSHL's @JSheltzer w/ a great team including undergrads, in @ScienceTM today
nytimes.com/2019/09/11/hea… @NYTScience
stm.sciencemag.org/content/11/509…
@carlzimmer @CSHL @JSheltzer @ScienceTM @NYTScience The inside story, as explained by a terrific @JSheltzer thread
@carlzimmer @CSHL @JSheltzer @ScienceTM @NYTScience A succinct summary to this report @sciencemagazine by @jocelynkaiser science.sciencemag.org/content/365/64…
another way I can put it: Essential to acknowledge that the essentiality of genes many not be essential ;-)
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Eric Topol
@EricTopol
A @nature issue dedicated to #ClimateChange
Yes, It's Time to Act. Great cover by @Jasiek_Kr
By the numbers: nature.com/immersive/d415… by @jefftollef #openaccess
@nature @Jasiek_Kr @jefftollef And so is @TheEconomist
all over #ClimateChange
economist.com/leaders/2019/0…
@nature @Jasiek_Kr @jefftollef @TheEconomist "The human imperative of stabilizing global #ClimateChange at 1.5°C" (already very serious at 1°C) science.sciencemag.org/content/sci/36… an extraordinary review by @oveHG @UQScience and collaborators @sciencemagazine
Read 4 tweets
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Eric Topol
@EricTopol
Thanks, Mr Hennessey. Apropos for the @WSJopinion deputy editor to label the respondents to the outrageous and iconoclastic op-ed as "intersectional lunatics."
On the money? No. Audacious? Yes.
#SDoH #medtwitter
@WSJopinion The only problem, Mr Hennessey, is that you proved a point, but it wasn't that one.
@WSJopinion Here's @P_Yerramilli's response @statnews with the right points statnews.com/2019/09/16/med…
Read 4 tweets
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Eric Topol
@EricTopol
Calling all activists in medicine. A @WSJopinion by former @PennMedicine dean says future doctors/med students should not be engaged in #guncontrol, #ClimateChange and matters of "social justice" wsj.com/articles/take-…
@WSJopinion @PennMedicine @ThisIsOurLane An inspirational (antidote) response to this op-ed by @PennMedicine faculty: inquirer.com/health/social-… by @CarolynCannu @zacharymeisel @rachel_fsimon citing @MonaHannaA's seminal work @PhillyInquirer via @PDX_Tom
@WSJopinion @PennMedicine @ThisIsOurLane @CarolynCannu @zacharymeisel @rachel_fsimon @MonaHannaA @PhillyInquirer @PDX_Tom Gratifying to see such a vigorous, compelling medical community response to Goldfarb's @WSJopinion here & social media.
Aligned w/ some points from August @NewYorker essay newyorker.com/culture/annals… "Meeting the challenges of modern medicine will require more than seeing patients."
Read 4 tweets

Related threads

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V2P Ψ
@de_perrier
#Cancer et #MédecinesAlternatives
#ThérapiesAlternatives
à l'#hôpital
"#Miviludes va être diluée" dit
@GeorgesFENECH (son ancien Pt, ex-magistrat)
A. @GUELAUD a écrit "Ils ne m'ont pas sauvé la vie" #EditionsDuToucan (= #TF1 ?) hommage à E. Marsaleix sous #emprise d'1 #secte ⤵️
(Suite)
Plusieurs sources d'information sur ce sujet aidant à éclairer la réflexion de chacun :
lexpress.fr/informations/e…
de 1996 @LEXPRESS
➡️ à noter : quelques différences entre les récits de cette histoire tragique
@CNEWS #PJI
Je ne suis pas à l'aise avec des propos du Dr Coscas(*)
Certes, la PEC (prise en charge, en soins) en #oncologie actuelle est différente de celle d'il y a 21 ans, fort heureusement les progrès sont là !
_______
(*) Dire que la 1ère chimio a marché, ss-entendu EM est sauvée ➡️ 🤔
Read 9 tweets
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ZacharySagerMD
@ZacharySagerMD
Wrote this piece with the help of a great team including @DrKevinHill. Below I'll share some of my thoughts about #opioids and opioid use disorder and how they present in #hpm and #palliative care, plus why we need to do a better job of addressing #addiction at end of life. 1/x
2/x Training in #KY gave me a front row seat to the #opioidcrisis. With an interest in #hpm I kept wondering what would happen to these individuals who developed an OUD and years later were prescribed opioids. How would I keep those patients safe and manage their pain?
3/x I continue to think that our field will struggle in years to come when survivors of the #opioidcrisis age, develop serious illness, and develop pain. Thinking about this, and reading @jeff_deeney article in @TheAtlantic theatlantic.com/health/archive… made me want to do more.
Read 13 tweets
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Dr. Jen Phillips
@ClutchScience
Great work as usual by @edyong209 detailing the troubling missteps of the germline #CRISPR editing story of last week. Ed's #3 leaves a lot more to unpack, though, so here's a thread:
theatlantic.com/science/archiv…
Some have interpreted He’s work as a (failed) attempt to replicate the natural 32bp deletion, but I don’t think that was the goal. I think he just hypothesized that any old indel in this genetic region would get the job done and went for it. 2/
Obviously there’s a whole host of things to be concerned about here, but this approach was shockingly cavalier even within the limited scope of what’s known about loss of CCR5 function. 3/
Read 16 tweets
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Gaetan Burgio
@GaetanBurgio
So let's comment on these reports that came out today on the creation of the first #CRISPR babies from a team at Shenzhen, China reported here -> technologyreview.com/s/612458/exclu… or here -> apnews.com/4997bb7aa36c45… and this Youtube video
What we know about it? Well not much. 1/ They have edited CCR5 gene, which prevent HIV entry. Have they edited CCR5 to generate a ∆32 mutation? no idea. It looks they edited CCR5 in the pronuclear and check editing by sequencing 3-5 days later -> 16/22 edited and 11 implanted
Twins were born with one carrying an heterozygous allele and the second baby an homozygous allele and one carried mosaic alleles. Details? No off target found but I don't have any details on this too. Are the CCR5 protein level changed? Again very little details on this.
Read 10 tweets
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Piyush Katariya
@AhamPiyush
In #reality there is no such things like Great Team, Great Organization, Great Nations. They only exist in our mind, it is only a consequence.

Only Great #Individuals exists and when they come together, #Team, #Organization and #Nation happen which are extraordinary.
All your efforts to change the consequences (Team, Organization, Nation) directly will be arduous and over exaggerated and in the end it will bring misery to all individuals who participated in the journey
All efforts must go be invested in #Individuals

There are only two ways in which investment will be fruitful
1. Invest in Individual's uniqueness and skills
2. Invest in Individual's consciousness
Read 6 tweets

Trending hashtags

#CripTheVote #HPM #NationalEmergency #malformations #paywall #disabled #FlipTheHouse #drugs #Miviludes #HHS #palliativecare #BigPharma #Brexit #CRISPR #cancer #Team #Muslims #disability #médecine #abortions #healthcare #ClinicalTrials #Cancer #Resistance #Medicaid
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