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I’m starting a thread of interesting recent reviews that I skimmed and recommend to read. First one is about the paternal epigenetic programming of offspring metabolism.

Diet-Induced Modification of the Sperm Epigenome Programs Metabolism and Behavior cell.com/trends/endocri…
“mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria”

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression cell.com/trends/immunol…
This one I read in full. Apart from ignoring quick delivery of glucose/easily hydrolyzed starch as a source of similar problems, it’s a really good one.
academic.oup.com/advances/advan…
GIP’s involvement in the pathophysiology of type 2 diabetes sciencedirect.com/science/articl…
The whole series in that issue of Peptides is quite interesting.

Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease sciencedirect.com/science/articl…
Livshits, Gregory, and Alexander Kalinkovich. “Inflammaging as a Common Ground for the Development and Maintenance of Sarcopenia, Obesity, Cardiomyopathy and Dysbiosis.” Ageing Research Reviews 56 (December 1, 2019): 100980. doi.org/10.1016/j.arr.…
An excellent modern view of apoproteins in ASCVD.

Apoproteins E, A-I, and SAA in Macrophage Pathobiology Related to Atherogenesis frontiersin.org/articles/10.33…
Mechanisms controlling hormone secretion in human gut and its relevance to metabolism joe.bioscientifica.com/view/journals/…
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Gabor Erdosi 🧩📄📊🧭
@gerdosi
Researchers are amused by the differences in fat absorption. Also, they think that the only problem with the following meal is the amount of fat.
“a small hamburger, small fries, and a small ice cream shake with fruit”
Let me explain it briefly. 1/n

ars.usda.gov/news-events/ne…
Refined wheat flour, cooked potatoes, the sugar in the shake contain a lot of quick-absorbing glucose. These maintain a bacterial population in the small intestine that is rich in Gram negative LPS producers. The long-chain fat in the diet helps the LPS get into chylomicrons. 2/n
What's more, simple sugars speed up chylomicron formation, pushing even more LPS into the lymphatics.
Now, what would be the best strategy to minimize this effect? (NB, some LPS translocation is perfectly fine.) Have you considered why LCFA are absorbed into lymph at all? 3/n
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Gabor Erdosi /erdoke
@gerdosi
What renders your HDL pro-atherogenic? The acute phase response, or more precisely, serum amyloid A (SAA), that displaces ApoA-I in HDL. Beautiful ‘design’ to deal with infection/infiltration, but a huge problem if the trigger remains unresolved.
ahajournals.org/doi/full/10.11…
The same underlying cause of high CVD mortality in late- and end-stage renal disease.
jasn.asnjournals.org/content/23/5/9…
Serum amyloid A impairs the antiinflammatory properties of HDL jci.org/articles/view/…
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Gabor Erdosi /erdoke
@gerdosi
Several recent studies/reviews highlight the importance of chronically suppressed autophagy in driving chronic diseases of civilization.
cell.com/cell-reports/f…
ebiomedicine.com/article/S2352-…
emboj.embopress.org/content/early/…
cell.com/cell-reports/f…
nature.com/articles/s4157…
frontiersin.org/articles/10.33…
And another review out in Cell.
cell.com/cell/fulltext/…
Chronically suppressed autophagy ⇄ chronic inflammation. Chronic hyperinsulinemia is just a tool to maintain the necessary metabolic support.
Read 13 tweets

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Scholarship #thread

In this thread I will talk about all the scholarship I've received in my life until now.
And how this helped me to be where I am today
I've got my first scholarship on 7th grade of elementary school on 2006 by OBMEP(Brazilian Olympiad of Mathematics of the Public Schools).
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this let me see math in a different way, much more fun and useful than before.
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A Picture Is Worth 1000 Words

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