THREAD: People want to understand when current lockdowns and restrictions will lift, and normal life starts to return. When will we begin to defeat #COVID19. There's an end to this. We need to define it. Define the stages of return to better times and how we’ll get there. 1/n
It’s not just a question of ending but adapting. Certain things will change. There isn’t an on/off switch that’ll flip one day. We'll unwind some measures and adopt others. We'll secure a better toolbox to deal with this threat. We won’t be caught flatfooted again. How? 2/n
Mitigation and Containment: We must use population wide mitigation where we have to (school closure, telework, shelter in place) and case-based interventions where we can. To better leverage case-based interventions as a suitable alternative then we need better tools 3/n
South Korea used massive testing coupled with technology to identify people who were infected, notify close contacts of their individual risk. They coupled this case containment with broad mitigation. straitstimes.com/asia/east-asia… 5/n
It’s not a one or the other strategy. We’re past containment in some areas, not others. It some places, case containment should still be a bigger part of our toolbox 6/n
If we’re successful at community mitigation we may return to a place where we can do more with case based interventions. But we need the tools to do that. We need the planning. We need a vision for the future. 7/n
As we slowly take our foot off the break of mitigation we’ll have to gradually rely on case containment strategies to keep sparks of infection from turning into brush fires, and brush fires turning into wildfires now raging in cities like New York, Seattle, and New Orleans. 8/n
Testing, Testing, Testing: We must widely test our population, diagnose mild and even asymptomatic cases. Requires point of care diagnostics in doctor's office. We must advance these immediately to market. It means serology to know who was exposed and developed immunity. 9/n
South Korea used mass testing (tested 1/200 people) and technology to implement mass case containment strategy. We must have tools to identify and isolate small outbreaks so we can lean less heavily on population-based mitigation. We don’t have those tools now. We need them 10/n
Life Science Marshal Plan: We must advance promising drugs in master protocol to speed testing. An antibody drug may be best promise for therapy by summer. We should manufacture in bulk in parallel so if something works we have doses to mass treat immediately 11/n
As noted in @WSJ, Sen. Daines proposed funding manufacturing and stockpiling of drugs and vaccines as soon as they’re developed but before approved. Once a drug or vaccine proves safe and effective, we’ll then have sufficient inventory to treat the population immediately 12/n 
We must adapt and innovate. We didn’t prepare in January for March. We must prepare in March for May. We have hard months ahead but must lay groundwork for a better future where coronavirus is less fearsome foe. Develop and deploy tools for viral battle. This is how we win 13/n
