1/10 More research is showing that those recovered from COVID-19 might be able help those currently suffering...
Time for a #convalescentplasma for #COVID19 intro #Tweetorial :
Time for a #convalescentplasma for #COVID19 intro #Tweetorial :
2/10 What is #convalescentplasma therapy?
-An individual recovered from COVID-19 (convalescent)has blood drawn/screened for virus-neutralizing antibodies
-If high levels of novel coronavirus antibodies are present, plasma can be given to individuals suffering severe COVID-19
-An individual recovered from COVID-19 (convalescent)has blood drawn/screened for virus-neutralizing antibodies
-If high levels of novel coronavirus antibodies are present, plasma can be given to individuals suffering severe COVID-19
3/10 Does #convalescentplasma work?
-History dating back to the 1890s; use for measles, mumps, H1N1, ebola, SARS, MERS
-Systematic review of use demonstrates reduced mortality and safety with use of convalescent plasma for SARS
-History dating back to the 1890s; use for measles, mumps, H1N1, ebola, SARS, MERS
-Systematic review of use demonstrates reduced mortality and safety with use of convalescent plasma for SARS
4/10 (Cont.)
-5 critically ill patients with COVID-19 improved with convalescent plasma therapy: decreased viral loads, normalized body temperature, resolution of PNA, weaned from mechanical ventilation after convalescent plasma infusion
-5 critically ill patients with COVID-19 improved with convalescent plasma therapy: decreased viral loads, normalized body temperature, resolution of PNA, weaned from mechanical ventilation after convalescent plasma infusion
5/10 Who can donate plasma?
-People who were recently ill, and now recovered (symptom free)
-Goal is high anti novel coronavirus antibodies and low viral load (RNA)
-People who were recently ill, and now recovered (symptom free)
-Goal is high anti novel coronavirus antibodies and low viral load (RNA)
6/10 Where can one donate plasma?
-The American Academy of Blood Banks (AABB) @AABB has info; contact local blood donation center
-Emerging locations on website CCPP19.org
-The American Academy of Blood Banks (AABB) @AABB has info; contact local blood donation center
-Emerging locations on website CCPP19.org
7/10 Is this a cure for COVID-19?
-Convalescent plasma is a promising stopgap therapy
-Convalescent plasma may reduce symptoms or mortality of COVID-19, but it is not preventative or curative
-Convalescent plasma is a promising stopgap therapy
-Convalescent plasma may reduce symptoms or mortality of COVID-19, but it is not preventative or curative
8/10 Teams involved in Convalescent Plasma research:
-Infectious disease
-Hematology
-Blood Banking specialists
-Laboratory Medicine
-Front lines of patient care
-Recovered patients
-And more!!!! Get involved!
-Infectious disease
-Hematology
-Blood Banking specialists
-Laboratory Medicine
-Front lines of patient care
-Recovered patients
-And more!!!! Get involved!
9/10 Potential uses:
-Therapeutic intervention for critically ill patients
-Prophylaxis (theoretically could reduce quarantine for exposed HCWs, an at risk population and finite resource)
-Therapeutic intervention for critically ill patients
-Prophylaxis (theoretically could reduce quarantine for exposed HCWs, an at risk population and finite resource)
10/10 Add your input/information, or ask any questions. We are all in this together!
@DrMJoyner @VincentRK @AlexAndersonMD @KreuterMD @CCPP_19 @VPrasadMDMPH @SARSCoV192 @ACasadevall1
@DrMJoyner @VincentRK @AlexAndersonMD @KreuterMD @CCPP_19 @VPrasadMDMPH @SARSCoV192 @ACasadevall1
