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1/ Little Thread about all The Misleading Medical Information still floating around about #Hydroxychloroquine & #Chloroquine & #Azithromycin & #ZelenkoProtocol - by 1 doctor - @zev_dr & #Remdesivir & more

Despite #TrumpIsNotADoctor has stopped saying "What do you have to lose?".
2/ #TrumpIsTheWORSTPresidentEVER

First, why it has been political all the way, suspected from day one:

"Trump had been touting HCQ for weeks, sparking worldwide shortages of HCQ & prompting negotiations with Indian PM Modi to lift export restrictions"

vanityfair.com/news/2020/04/i…
3/ #Trump2020

Indian PM Modi and Trump held a rally together.

"Mr Trump wanted to show people in the US that he was hugely popular abroad and that he was capable of negotiating good deals out of a country he once described as the king of tariffs"

bbc.com/news/world-sou…
4/ #Hydroxychloroquine & #Azithromycin

The largest *Multicenter trial* was done in Albany, NY. *600 patients in 22 hospitals*

"Acquired 70K Doses of Hydroxychloroquine, 10K doses of Zithromax & 750K Doses of Chloroquine"
👇
governor.ny.gov/news/amid-ongo…
👇
nypost.com/2020/04/23/hyd…
👇
5/ #Hydroxychloroquine & #Azithromycin

Why go out with this when it's not been peer-reviewed yet? It is obviously a heads-up.

"It's been tried this on virus after virus & it never works out in humans. Dose needed is just TOO HIGH, Science Magazine"

theguardian.com/science/2020/m…
6/ Again #Hydroxychloroquine & #Azithromycin

"Around 30 patients with symptoms of #COVID19 had reported serious side effects of heart disorders after taking HCQ, Martin told AFP. Also warned against other drugs such as the antibiotic Azithromycin"

euronews.com/2020/04/02/fra…
7/ Only #Hydroxychloroquine

"Hospitals in Sweden have stopped using the malaria drug on #COVID19 patients after reports it was causing blinding headaches & vision loss"

Confused? Surely they used HCQ, as CQ is not on the market in Norway or Denmark.

dailymail.co.uk/news/article-8…
8/ #Chloroquine

Brazil researchers planned to enroll 440 people in a double-blind study testing chloroquine against #COVID19

"Findings suggest that *higher CQ dosage* (10 days) should not be recommended for COVID19"

Why try high dose? See 5.

medrxiv.org/content/10.110…
9/ #Hydroxychloroquine & #Azithromycin

"A panel of experts convened by NIH recommends against doctors using a combination of HCQ and AZ for the treatment of COVID19, as associated with QTc prolongation in COVID19 patients"

This is NOT just #DrFauci !

npr.org/sections/coron…
10/ #Azithromycin, #Chloroquine, #Favipiravir, #Hydroxychloroquine #Lopinavir / #Ritonavir & #Remdesivir

"Estimators of LQTS risk levels indicated a very high or high risk for all COVID-19 repurposed drugs"

Not AZ, but "cases of TdP have been reported"

medrxiv.org/content/10.110…
11/ #ZelenkoProtocol only brings Zinc to the table, in addition to HCQ & AZ. Based on this study, which does *not* mention Coronaviruses at all, as published in 2004. In study *IN VITRO* is mentioned 8 times, while *IN VIVO* is mentioned just 1 time.

ncbi.nlm.nih.gov/pmc/articles/P…
12/ #ZelenkoProtocol

On April 30th @zev_dr tweeted:

Gateway Pundit, which is entirely political & stupid, ref @sickendun2death

Links to IlTempo, in Italian, which links to the study. Conclusion before "ACKNOWLEDGEMENT".
👇
onlinelibrary.wiley.com/doi/epdf/10.10…
👇
13/ #Trump2020 & his reason for advertising #Hydroxychloroquine

#Trump & his allies used this study to advertise the use of HCQ
👇
mediterranee-infection.com/hydroxychloroq…
👇
International Society of Antimicrobial Chemotherapy RETRACTED the study already April 3rd!
👇
14/ #Remdesivir

Remdesivir has gotten a lot of press lately.

"The mortality rate for the remdesivir group was 8%, compared to 11.6% for the placebo group; that mortality difference was NOT statistically significant"

Its Legal Status = Investigational.

statnews.com/2020/04/29/gil…
15/ #Resist #Resisters #Resistance

Still searching #Hydroxychloroquine #Chloroquine ?

"Medicines Agency cannot authorise hydroxychloroquine for COVID-19 if the company manufacturing the medicine does not apply for an authorisation"

#BigPharma = Scared

laegemiddelstyrelsen.dk/en/news/2020/c…
17/ #ZelenkoProtocol

@zev_dr Triple-Links so you don't find the actual source: In Tweet 12.

Of 6 hospitalized, only 3 received suppos. spec.
treatment for COVID-19:

1 got #Hydroxychloroquine
1 got HCQ + #ritonavir / #darunavir
1 got HCQ + #anakinra
18/ #TrumpIsTheWORSTPresidentEVER

#Hydroxychloroquine & #Azithromycin & #Cardiology

"Patients hospitalized & receiving HCQ for COVID-19 frequently *experienced QTc prolongation & ADEs, including a case of torsades de pointes* with admin. of HCQ and AZ"

jamanetwork.com/journals/jamac…
19/ #Hydroxychloroquine & #COVID19

"200 mg daily for 3 days followed by a maintained dose of 800 mg daily for remaining days (2/3 weeks - mild/moderate/severe). HCQ did not result in a significantly higher negative conversion probability than SOC alone"

medrxiv.org/content/10.110…
20/ #Hydroxychloroquine #TrumpMeltdown #NewYork

"1376 patients during a median follow-up of 22.5 days. 811 received HCQ. 600 mg twice on day 1 then 400 mg daily for a median of 5 days. 45.8% of the patients were treated within 24 & 85.9% within 48 hours"

nejm.org/doi/full/10.10…
21/ #ZelenkoProtocol

1. Abstract Conclusion = Zinc helps
2. But: Paragraph 2 under METHODS
3. Essential to read study's methods

"Patients were *included* if ... had either been discharged from the hospital, transitioned to hospice or expired"

Full PDF:
drive.google.com/file/d/1XkIHqV…
22/ #Hydroxychloroquine & #Chloroquine & #Azithromycin

Norwegian Medicines Agency published a Warning April 23 & updated it on May 6.

Translates perfectly to English:
bit.ly/3fBSN5b

Citations:
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…

#TrumpLiesAmericansDie
23/ #Remdesivir & #Vaccines & #SARSCoV2 & #COVID19

Norwegian Medicines Agency reports:

"Investigations started in Europe"

EMA - Remdesivir:
ema.europa.eu/en/news/ema-st…

NMA - Medicines & Vaccines:
legemiddelverket.no/english/covid-…

#TrumpPressConf #TrumpLiesAmericansDie
24/ #COVID19 #SARS_CoV_2

Number 4 out.

"1438 in #NYC - Compared with Patients receiving Neither, Cardiac Arrest was Significantly more Likely in Patients Getting #Hydroxychloroquine & #Azithromycin - To our knowledge; largest report of adverse effects"

jamanetwork.com/journals/jama/…
25/ #Hydroxychloroquine & #Azithromycin

Comparison: In Study 2 the 119 HCQ/AZ group.

nature.com/articles/s4159…

"Patients with #COVID19 treated with HCQ/AZ, QTc was significantly prolonged"

ahajournals.org/doi/10.1161/CI…

Lacks doses: "QTc prolongation. Seldomly needed to discontinue"
26/ #Hydroxychloroquine #TrumpIsALaughingStock

"Eficacy data & the irrefutable clinical data collected through the #COVID19 Global Rheumatology Alliance registry establish that #Lupus patients on baseline therapy with HCQ are NOT universally protected"

ard.bmj.com/content/early/…
27/ #SARSCoV2 #COVID19 #TrumpGate #TrumpLiesAmericansDie

DMA has Up-to-Date lists of Ongoing Trials of Vaccines & Medicines.

Significants in Yellow = Design can potentially provide important knowledge.

Vaccines: laegemiddelstyrelsen.dk/da/nyheder/tem…

Medicines: laegemiddelstyrelsen.dk/da/nyheder/tem…
28/ #MentalHealthAwareness

Feeling down because of the lack of truly effective Therapeutics and Vaccines?

Maybe this beautiful song is one to add to your playlist?

Full version as MP3 here: drive.google.com/file/d/1bDjdhl…

29/ #Hydroxychloroquine #Chloroquine #Azithromycin

"A widespread misconception that EUA means FDA-approved, driven by certain irresponsible politicians and members of the media", Kesselheim, Prof. of Medicine, Harvard

FULL: bit.ly/3dY6TvZ

TWP: wapo.st/3fXcSDk
30/ #TrumpHasNoPlan

Now that #Trump claims he's taking #Hydroxychloroquine - here is a Timeline.

Full PDF: bit.ly/3bKyP5g

Source: washingtonpost.com/politics/2020/…
31/ #TrumpHasNoPlan

Since all the Side Effects of #Hydroxychloroquine & #Azithromycin are never mentioned in the press, usually just the cardiovascular ones, documented well above, here are both lists. From the European & Norwegian Medicines Agency SPCs
👇 + 👇
32/ #Hydroxychloroquine

"What do you have to lose? Take it!"
- Trump, April 4

Didn't want to add this.

But now #Trump criticizes the VA Study b/c they were "old & sick" - as if only with negative outcome.

Median age = 69

Trump:

* Old (73)
* Obese
* Hearth disease

👇 + 👇
33/ #Hydroxychloroquine & #Azithromycin

Perspective: Number 32.

Deaths / Age

1. HCQ group: 27.8% / 70yr
2. HCQ + AZ group: 22.1% / 68yr
3. Control Group: 11.4% / 69yr

Risk groups.

*All ages* in USA as of now:

(92058 ÷ 1534064) × 100 = 6%

Full PDF: bit.ly/2zQhrPc
34/ #Hydroxychloroquine & #Chloroquine & #TrumpVirus

"WHO epidemiologist: Largest single-day increase in Coronavirus Cases"

Live page, so search for "Largest single-day increase" in the page itself.

cnn.it/3bSrCAf

Interestingly the Sharpest Rise in (H)CQ Trio
👇
35/ #ZelenkoProtocol & #Hydroxychloroquine

See Number 21 first.

Didn't even know confirmed administration.

"Cohorts were identified based on medications *ordered rather than confirmed administration*, which may bias findings towards favoring equipoise between the 2 groups"
👇
36/ #SARSCoV2 & #COVID19

The meta-analysis of treatment with #Hydroxychloroquine or #Chloroquine with/without a #Macrolide published in The Lancet May 22 was retracted June 5.

A NEJM article too. It was not about medical treatment.

Same obvious reason:
thelancet.com/journals/lance…
37/ #SARSCoV2 & #COVID19

2 Major Studies cited by press that didn't use Surgisphere's DB at all & studied #Hydroxychloroquine and/or #Azithromycin

1. Number 20 (NEJM)
2. Number 24 (JAMA Network)

More needed, so:

HCQ is back in WHO's Solidarity Trial: who.int/emergencies/di…
38/ #SARSCoV2 & #COVID19

June 15:

"FDA revokes Emergency Use (EUA) of #Hydroxychloroquine and #Chloroquine … As of the date of this letter, the oral formulations of HCQ and CQ are no longer authorized by FDA to treat COVID-19"

First 2 pages explains:

drive.google.com/file/d/1vEDT5y…
39/ #Hydroxychloroquine

Solidarity Trial was resumed after Number 36.

#COVID19 treatment stopped b/c of:

* UK Recovery Trial
* French Discovery Trial
* Solidarity Trial itself
* Cochrane Review

But not for pre/post-exposure prophylaxis.

Since link in Number 37 is updated
👇
40/ #COVID19

Part of UK Recovery Trial in Number 39.

Corticosteroids are commonly used in ICUs based on clinical evaluation.

Based on 2,104 randomized *very sick*, #Dexamethasone is "first drug to be shown to improve survival", Prof. Horby.

Read both:
drive.google.com/file/d/1yyrhZG…
41/ #COVID19

Trial design:
* 176 hospital orgs.
* 28-day mortality
* Randomized
* 4321: Usual care
* 2104: #Dexamethasone

Reduced deaths:
* 1/3: Invasive ventilator
* 1/5: Oxygen only

Of 6, #Hydroxychloroquine was stopped, ref Number 40.

PRELIMINARY:
drive.google.com/file/d/1-nkmVT…
42/ #TrumpFailedAmerica

Published July 16:

#Hydroxychloroquine in Nonhospitalized Adults With Early #COVID19

* Randomized
* Double-blind
* Placebo-controlled

HCQ did not substantially reduce symptom severity in outpatients with early, mild COVID-19

acpjournals.org/doi/10.7326/M2…
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