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Feb 7 • 4 tweets • 2 min read
Long-term #depression is associated with #brain aging & poor cognitive function

1. 649 adults aged 23-36 years were followed up for 25 years in USA.
Participants with elevated depressive symptoms had on average a 3-year greater brain age.
#MedTwitter #Alzheimers #NeuroTwitter
2. People with elevated depressive symptoms were associated with 3-times higher odds of poor cognitive function in midlife.
doi.org/10.1016/j.jad.…
3. Take home message
*Adults should be screened for the presence of depressive symptoms and those with depression should be treated, in order to reduce the risk of cognitive decline and accelerated brain aging in later life.
4. Possible reasons for this association:
Increased inflammation and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis are two of the most consistent biological findings in major depression, which have been linked to premature aging also.

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More from @hyderabaddoctor

Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Feb 8
Vitamin D is effective in decreasing risk for diabetes in adults with prediabetes

1. In a meta-analysis, the risk of #diabetes reduced by 15% in adults with prediabetes, who were given #vitaminD: 20,000 IU (500 mcg) weekly; OR 4,000 IU (100 mcg) daily, as compared to placebo.
2. The 3-year absolute risk reduction in developing diabetes was 3.3%.
The absolute risk reduction number is small, especially when compared with the risk reduction seen with intensive lifestyle changes (58%) and metformin (31%).
#MedTwitter
doi.org/10.7326/M22-30…
3. There are certain limitations.
*The effects of vitamin D can not be generalized to healthy adults, as it was tested in only those with prediabetes.
*The safety of prolonged vitamin D use on regular basis is not yet fully clear.
Read 4 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Feb 7
Persistent #running can add 6 years to your #life

1. Running has several benefits including lesser risk of death and longer #survival. As per a research study, persistent running over 15 years can add 5.9 years to life.
doi.org/10.1016/j.jacc…
2. As per study, runners added 3 years to life as compared to never runners, and persistent runners (who continued running through the follow up period) added 5.9 years to life.
All cause death reduced by 29% and cardiovascular death reduced by 50% among consistent runners.
3. The benefits on survival and reduction in death were seen in all runners.
Weekly running even <51 min, <6 miles, 1 to 2 times or <6 miles/hour was sufficient to reduce risk of death, compared with not running.
Read 4 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Feb 7
Relatively higher risk of Guillain-Barre Syndrome (GBS) after Janssen #COVID19 #Vaccine

1. Within 21 days of vaccination, GBS reporting rates per 1 million doses were 3.29 for the Janssen vaccine versus 0.29 and 0.35 for the Pfizer and Moderna vaccines, respectively
#MedTwitter
2. Within 42 days of vaccination, reporting rates per 1 million doses were 4.07, 0.34, and 0.44, respectively for Janssen, Pfizer and Moderna vaccines.
jamanetwork.com/journals/jaman…)%3Ae2253845.%20doi%3A-,10.1001/jamanetworkopen.2022.53845,-COVID%2D19%20Resource
3. The Advisory Committee on Immunization Practices (ACIP) preferentially recommends that people age 18 years and older receive an mRNA COVID-19 vaccine rather than the Janssen adenoviral vector vaccine when both types of COVID-19 vaccine are available.
Read 4 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Feb 6
A common habit resulted in severe #vision impairment in a young woman

1. 30-year old Manju had severe disabling vision symptoms for one and half years. This included seeing floaters, bright flashes of light, dark zig zag lines and at times inability to see or focus on objects.
2. There were moments when she could not see anything for several seconds. This occurred mostly at nights when she got up to use washroom. She was evaluated by an #eye specialist and detailed evaluation was found to be normal.
She was referred to rule out neurological causes.
3. I reviewed the history. Symptoms had started after she quit her job of a beautician in order to take care of her specially abled child.
She picked up a new habit of browsing through her smartphone for several hours daily, including >2 hours at nights with lights switched off.
Read 13 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Feb 4
An elderly man who repeatedly kicked the woman ahead of him while waiting in queue to board a flight

1. 69-year old Balu, while waiting to board a flight, started to repeatedly fling his right leg that hit the woman standing in front. The woman was shocked with this incident.
2. She was terribly upset and remarked-"just because boarding is delayed & you are restless, doesn't mean you can kick me like that. Moreover, you can't take advantage of you being older to me".
But Balu denied any wrongdoing and said the leg started shaking without his control.
3. As soon as Balu landed in Hyderabad, he consulted a physician, who diagnosed focal motor #seizures (fits) and started him on anti-epileptic drugs (AEDs). Similar symptoms repeated after one month despite being on regular AEDs, and he was referred for my opinion.
#Medtwitter
Read 8 tweets
Dr Sudhir Kumar MD DM🇮🇳 Profile picture
Feb 2
Running is not detrimental to #knee #cartilage

1. The general health benefits of #running are well-established, yet concern exists regarding the development and progression of #osteoarthritis
A recent research examined the effects of running on knee cartilage using MRI scans.
2. Knee cartilage thickness and volume decreased immediately after running, with declines ranging from 3.3% for weight-bearing femoral cartilage volume to 4.9% for patellar cartilage volume.
#MedTwitter #marathon #fitness
3. Tibiofemoral cartilage T2 relaxation times on MRI recovered to baseline levels within 91 minutes.
Existing cartilage defects were unchanged within 48 hours post-run, as examined on MRI.
Read 5 tweets

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