Thread by @RajlabN

#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (#15DAYTRENDS):

49.7% XBB.1.5
8.3% XBB.1.16
8.3% XBB.1.9.1
2.3% XBB.1.9.2
2.1% XBB.1.16.1
1.6% XBB.1.5.1
1.4% XBB.2.3

>> Low Sequence Count <<
#SARSCoV2 Tracker: tinyurl.com/mryj4uu7 Updated: 04/30/23

1/n

#COVID19 #VariantDashboard - #USA
[without sequences from "Airport Surveillance"]

Top lineages (#15DayTrends):

XBB.1.5 (61.1%)
XBB.1.9.1 (8.0%)
XBB.1.16 (3.5%)
FL.2 (1.7%)
XBB.1.5.1 (1.7%)
XBB.1.5.17 (1.7%)
XBB.1.9.2 (1.4%)
XBB.1.5.15 (1.2%)

2/n

Airport sequences constitute a significant proportion of sequences (~27%; #15DayTrends)

Its going to be a three way race to outcompete XBB.1.5*: XBB.1.9* vs XBB.1.16* vs XBB.2.3*

As of now, XBB.1.16* family looks to over take everything else!

3/n

Sequence count by US States

#NewYork and #California have submitted a big share of sequences with specimen collection dates on or after 04/15/2023

XBB.1.5 is still at the top spot; followed by XBB.1.9.1 and XBB.1.16

4/n

.@CDCgov updated variant proportions estimates on 04/28/2023 (updated every Friday)

Prudent to start tracking EG.1*, XBB.1.16.1 & XBB.2.3* as well

https://twitter.com/RajlabN/status/1651967457064628228

5/n

XBB.1.16 has the potential to outcompete all other circulating lineages.

Everyone is closely watching XBB.1.16 hotspots for clues

Tracker: public.tableau.com/app/profile/ra……

6/n

XBB.1.16 is one of the fittest variant in circulation right now.. and is picking up additional mutations... "its the one to watch"

H/T @ErinMPrater @WellatFortune
@FortuneMagazine
fortune.com/well/2023/03/3…

7/n

Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/ hospitalizations.

Get updated if you haven't already!
public.tableau.com/app/profile/ra…

8/n

.@CDCgov has authorized a second dose of the bivalent Omicron-BA.5 vaccine for older adults and immunocompromised adults

https://twitter.com/RajlabN/status/1648819491378192384

9/n

#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19

public.tableau.com/app/profile/ra…

10/n

#COVID19 #Hospitalizations in the #UnitedStates

>60 yr old & immunocompromised Have a good look at @CDCgov info on #Boosters!

#Ventilate Indoor spaces

Sick? --> Wear a good quality #Mask!

Hospital Tracker (by States, by age group):public.tableau.com/app/profile/ra…

11/n

Status of the latest #COVID19 Wave in #NewYork #Bellwether #State

XBB.1.5 is still the top circulating lineages in NY

[includes airport surveillance seqs]

12/n

Status of the latest #COVID19 Wave in #California

XBB.1.5 is still the top circulating lineage in CA (#15DayTrends)

[includes airport surveillance sequences]

13/n

USA Airport surveillance update #15DayTrends

155 sequences from 6 US States (#California, #NewYork, #Washington, #NewJersey, #Georgia and #Virginia) from @CDCgov's Traveler-Based Genomic Surveillance Program.

*Includes pooled swabs & Many bad QC seqs

14/n

As COVID Tracking Wanes, Are We Letting Our Guard Down Too Soon?

"Closing up shop too early could mean we are blindsided" “You have to maintain a base level of sequencing for new variants"

H/T @DohenyKathleen @WebMD
webmd.com/covid/news/202…

15/n

The next pandemic could be ‘as infectious as this one but far more lethal’—and make COVID look like a cakewalk, expert warns

H/T @ErinMPrater @WellatFortune
@FortuneMagazine
fortune.com/well/2023/04/2…

16/n

Observational data recorded by the LACDPH suggests those who have been infected with the rapidly spreading Omicron strain XBB.1.16 — better known as Arcturus — have shown symptoms of conjunctivitis.

nypost.com/2023/04/30/new…

"Given limited data, it is too early to know with certainty if XBB.1.16 is truly associated with higher rates of conjunctivitis, amid an already active allergy season in Southern California"

ph.lacounty.gov/phcommon/publi…