Discover and read the best of Twitter Threads about #fab

Most recents (4)

Since my recent "tweetorial" about the history of ring sideroblasts & Prussian blue seems to have been well received, I thought I’d follow up with the fascinating and sordid history of the term, “Refractory Anemia” (RA). (This ugly #MDS image is from a book I edited years ago.)/1
The 1982 #FAB #MDS classification included chronic myelomonocytic leukemia (CMML), plus 4 categories with the term RA: 1) RA, 2) RARS (i.e., RA w/ ring sideroblasts), 3) RAEB (RA with excess blasts), and 4) RAEB-t (RAEB in transformation to #AML). But where did "RA" come from?/2
Iron salts had been used since the 17th century to treat “chlorosis” – i.e., the green sickness, characterized by weakness and pallor. Thomas Sydenham (1624–1689) is usually given credit for first rational use. Here's a classic painting of a young woman fainting from chlorosis./3
Read 25 tweets
There is an interesting history behind these cells, so familiar to hematologists & pathologists: ring (formerly 'ringed') sideroblasts. While most commonly associated with #MDS or inherited disorders like #XLSA, they can also result from ethanol or TB drugs - even hypothermia./1
Sideroblasts and siderocytes - red cells and their precursors with iron granules in the cytoplasm visualized by a chemical reaction - were first described by Hans Grüneberg in 1942, a Jewish refugee from Germany working in London @ucl from 1933. /2
In 1955, Sven-Erik Björkman, working in Jan Gösta Waldenström's hematology unit @lunduniversity (thus far this tweetorial has 100% umlaut surnames!) noticed 4 of his anemic patients had weird sideroblasts: the iron granules encircled the nucleus. One of them developed leukemia./3
Read 23 tweets
The #NHScrisis as it unfolds on twitter:
Doctors and nurses go against the masters and take a sneaky shot of a corridor. Comms team go nuts because you can see a quarter of someone’s face and you can’t tell if it’s a patient or Julie from corporate.
Meanwhile the ambulance service are snowed under whilst finding time to tweet a story in just enough detail as to make sure that if a 94 year old was on twitter, they’d know it was them they’re talking about.
Read 29 tweets
@fernandokrammer 1)todos #países tem #StrangersThings
2)nem todos podem escolher
3)qdo fazemos nossa parte c/ #Empatia ,colaboramos p/ o lugar ficar melhor
@fernandokrammer depois do silêncio adotado ao observar que NÃO foi nada inteligente apoiar o #Golpe feito na democracia #brasileira, é incoerente se acovardar diante as manobras direcionadas nos diferentes sistemas
#justiçabrasileiraPartidária 😱
Read 395 tweets

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