Discover and read the best of Twitter Threads about #heterogeneity

Most recents (5)

1/5 "In healthy individuals, normal #body #temperature is variable and has decreased consistently since the 1860s."…
2/5 "The #gut #microbiome is a key modulator of body temperature variation both in #health and critical illness, and is thus a major, understudied target for modulating #physiologic #heterogeneity in #sepsis."
3/5 The Carrington Event was the most intense geomagnetic storm in recorded history, peaking from September 1 to September 2, 1859 during solar cycle 10.
Read 5 tweets
🧵 "#Criticality: A Balance Between #Robustness and #Adaptability"

Today's SFI Seminar by @cgershen @cgg_mx:
Regarding systems at the #EdgeOfChaos
Identifying #PhaseTransition dynamics
Citing @WagnerEvolution on #Robustness
Contrasting it with #Chaos (fragile, hard to predict, etc.)
And then #Criticality, somewhere in the middle... ImageImageImageImage
With #criticality, due to #PowerLaw(-like) distributions:

"Most of the changes will be small, but for some, you can have large changes."

See also #fractals

Key history point: Stuart Kauffman's #random #Boolean #networks (1969!)

Updated by @cgershen in 2004 ImageImageImageImage
Read 12 tweets
We are thrilled to share #Starfysh ⭐️ an auxiliary deep generative model for multi-modal analysis and integration of spatial transcriptomic (ST) datasets and histology images, and its application to heterogeneous #breastcancer tumors! 😃 1/ Image
Incredibly fortunate to have a passionate, collaborative & talented team that didn't slow down with all the challenges of the past few years 🙏: @SiyuHe7 @YinuoJin6, @AchilleNazaret @shi_lingting and a fruitful and ongoing collaboration with @GeorgePlitas and Sasha Rudensky. 2/
Using ST, we wanted to find out if our previously observed continuous phenotypic expansion of intratumoral immune states (…) could be explained by the #spatialdynamics of immune cells and exposure to different environmental signals and nutrient supply? 🧐 3/
Read 15 tweets
"The 21st Century Question: Emergently Engineering the Future"

Follow this 🧵 today and tomorrow for highlights from our 2022 #AppliedComplexity Network and Board of Trustees Symposium:…

#Web3 #Cities #Polarization #EmergentEngineering #Decentralization
We start with a talk by SFI President David Krakauer:

"Would anyone care to guess why we're so GOOD at building transistors and so CRAP at designing drugs?"

"This thing [points to transistor] lives in a centralized system. This thing [points to cancer drug] lives in US."
"I'm going to pick on economics, because we like to do that at SFI. 'Ooh, look at that cover! So techy. Global, heat maps...' But here's 'Networks' [in the textbook]. THAT'S IT. Here's '#ComplexityEconomics.' NOTHING."
Read 111 tweets
🚨🧠📄🍾 🤪🥳 For some reason all our papers are coming our within 2 weeks!
Here’s the latest in @GreenJournal, on the relationships between 1) patterns #tau and #amyloid PET and 2) #Alzheimer’s clinical #heterogeneity and #APOE4.…

1/n Image
#Alzheimer is associated with #heterogeneous clinical presentations. Patients develop symptoms at different ages (even sporadic AD can start early) and clinical syndromes vary: not everyone shows a “typical” amnestic syndrome (which is not very sensitive nor specific to AD!)

2/n Image
Specific non-amnestic syndromes are often associated with AD, like #PosteriorCorticalAtrophy (PCA, the visual variant of AD) or the logopenic variant of Primary Progressive Aphasia (lvPPA).

#APOE4 is associated with an earlier onset but also a more amnestic syndrome.

3/n Image
Read 17 tweets

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