Discover and read the best of Twitter Threads about #tau

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psycnet.apa.org/search/display… A meta-analysis of 14 RCTs 🙄 for #BPD found that Treatment As Usual (TAU) helped a bit, Major finding given that #TAU is meant to be a control/inert treatment in #RCTs. This finding suggests more #research on the nature of TAU is needed. Brand new study!
While on the topic of meta-analyses, let it be known that once upon a time not very long ago (ca. 2006) in the world of academic #psychology, meta-analyses were looked down upon: /3
not experimental; boring; gl getting a tenure track job w a meta-analytic research program. Things have change and they are now the rage it seems. 3/3
Read 4 tweets
So @Merck’s BACE-1 inhibitor Verubecestat resulted in “near-maximal reduction” of amyloid-beta in cerebrospinal fluid and “modest reduction” in brain amyloid. But it didn’t help even #Alzheimer’s disease, even "mild" Alzheimer's. A few thoughts:
1. Many companies are holding on to the hope that giving #tau- and #amyloid-busting drugs earlier, before Alzheimer's sets in, could prevent the disease. The FDA might even be open to using tau and amyloid as biomarkers to approve #Alzheimers drugs cen.acs.org/articles/96/i9…
2. But if we already know these drugs can lower amyloid-beta levels and *not* stop disease progression, is that really a good idea? I'd love to see the long term studies done, but the idea of drug approval based on biomarkers, and not cognitive markers, seems like a can of worms.
Read 5 tweets

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