1/5 "In healthy individuals, normal #body #temperature is variable and has decreased consistently since the 1860s."

atsjournals.org/doi/10.1164/rc… 2/5 "The #gut #microbiome is a key modulator of body temperature variation both in #health and critical illness, and is thus a major, understudied target for modulating #physiologic #heterogeneity in #sepsis."

1/2 Compelling share from @oliver_phil...

"Remarkably, previously #hospitalized and #nonhospitalized patients remained with decreased numbers of CD1c+ #myeloid DCs and pDCs seven months after #SARSCoV2 #infection."

#COVID19 IS NOT #mild

https://twitter.com/oliver_phil/status/1619701525592559617

2/2 "Moreover, the expression of #dendritic #cell (DC) markers such as #CD86 and #CD4 were only restored in previously #nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed."

#CovidIsNotOver

1/8 "#Ultraviolet #germicidal #irradiation (#UVGI) is known to #inactivate various #viruses and #bacteria, including #SARSCoV2, and is widely applied especially in #medical facilities."

#COVID19 #CovidIsNotOver #COVIDisAirborne

pubs.acs.org/doi/10.1021/ac…

An abstract thread 🧵... 2/8 "This #inactivation results from the #high #photon #energies causing #molecular #bonds to break, but when #nonpathogen #molecules are affected, #unwanted #effects may occur."

1/4 "#Children have diverse #polyclonal #SARSCoV2-specific #naïve #Tcells."

sciencedirect.com/science/articl… 2/4 "Adults have #clonally expanded exhausted #SARSCoV2-specific memory #Tcells."

1/9 Exciting work from Simona Nitti and colleagues... good news for #space #weather forecasting/predictions and correlated #disaster #preparedness, #bioterrorism, #pandemic preparedness, #power #outages, #cybersecurity, etc.

academic.oup.com/mnras/article-…

#heliobiology 2/9 "#Coronal #holes (#CHs) are the source of #high-#speed #streams (#HSSs) in the #solar #wind, whose interaction with the slow solar wind creates #corotating #interaction #regions (#CIRs) in the #heliosphere."

1/4 "In this cohort study, more #severe acute illness, a higher #Charlson #Comorbidity #Index score, and being #unvaccinated were associated with a higher risk of reporting #COVID19 symptoms lasting 28 days or more."

#Unvaccinated and #immune naive or #convalescent? 2/4 "Participants with #COVID19 were more likely to seek medical care for #diabetes, #pulmonary, #neurological, and #mental health–related #illness for at least 6 months after onset compared with their pre-#COVID #baseline health care use patterns."

1/5 Fascinating work from Jae-Hyun Yang and colleagues on #mammalian #aging, published in Cell...

An abstract thread 🧵...

"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."

cell.com/cell/fulltext/… 2/5 "In #yeast, #epigenetic information is lost over time due to the relocalization of #chromatin-modifying proteins to #DNA breaks, causing cells to lose their identity, a hallmark of yeast #aging."

1/14 #Men and #women experience disease differently. This is reminiscent of #SyndromeX and other chronic disease like #MECFS, #slow #virus manifestations, and even #LongCovid and post-acute sequelae of #SARSCoV2.

A thread summary article 🧵

anu.edu.au/news/all-news/…. 2/14 "#Women are up to 75 per cent more likely to experience #adverse #reactions to #prescription #drugs than #men because of a range of differences in #traits between the #sexes, according to a new study from The #Australian #National #University (#ANU)."

1/4 "... findings suggest #organizational #priorities can potentially #disturb #natural #patterns of #gestation and #birth #timing..."

journals.plos.org/plosone/articl… 2/4 "... with a potential to improve U.S. #perinatal #outcomes with organizational models that more closely resemble those of #England and the #Netherlands."

1/3 "We report reduction in proportion of hospitalisations and deaths from SARS-CoV-2 infections during the Omicron variant dominated wave in Malawi, in the context of high SARS-CoV-2 seroprevalence and low COVID-19 vaccination coverage."

thelancet.com/journals/eclin… 2/3 "These findings suggest that COVID-19 vaccination policy in high seroprevalence settings may need to be amended from mass campaigns to targeted vaccination of reported at-risk populations."

1/3 "While one of #Geotail’s two #data #recorders failed in 2012, the second continued to work until experiencing an #anomaly on June 28, 2022. After attempts to remotely repair the recorder failed, the mission operations were ended on November 28, 2022"

nasa.gov/feature/goddar… 2/4 "With an orbit that took it as far as 120,000 miles from Earth at times, #Geotail helped provide complementary data from remote parts of the #magnetosphere to give scientists a complete picture of how events seen in one area affect other regions."

1/2 "#COVID-19 infection, including long-COVID, is associated with increased short- and long-term risks of #CVD and mortality."

#cardiovascular #disease #health #COVID19 #SARSCoV2

https://twitter.com/EricTopol/status/1615907984420536320

2/2 "Ongoing monitoring of #signs and #symptoms of developing these #cardiovascular #complications #post #diagnosis and up till at least a year post recovery may benefit infected patients, especially those with #severe #disease."

#PASC #LongCovid

1/4 "#Immunity #debt vs post covid immune deficiency (PCID).
Not an immunology expert, but here are 25 papers/articles that collectively argue for PCID.
Immunity debt is a made up term that reflects poor science."

-@AndrewEwing11

Good share @AndrewEwing11!
H/T @yaneerbaryam

https://twitter.com/AndrewEwing11/status/1588306678814056449

2/4 Since the start of the pandemic, in 2019, #COVID19 cases, particularly asymptomatic and subclinical cases, and convalescents with some form of post-acute sequelae of #SARSCoV2, i.e. #LongCovid, #LongCovidKids, etc., may all have been grossly underestimated.

1/5 "The analysis revealed that older, #cognitively #healthy #brains showed similar amounts of #dissolvable, #non-#fibrillar #amyloid #protein as #brains of #Alzheimer’s #patients."

#aβ #Aβ #fibrils

gero.usc.edu/2023/01/05/new… 2/5 "But, as the researchers expected, the brains of #Alzheimer’s patients had higher amounts of #insoluble #Aβ #fibrils, the form of #amyloid #protein that aggregates to form the telltale “#plaques” seen in the #disease,..."

1/5 "#SARSCoV2 #infection is associated with a #surprising number of #morbidities."

#amyloidogenesis #aβ #fibrils #COVID19 #SARSCoV2
#spike
#protein

pubs.acs.org/doi/10.1021/ja… 2/5 "#Uncanny #similarities with #amyloid-#disease associated #blood #coagulation and #fibrinolytic #disturbances together with #neurologic and #cardiac problems led us to investigate the #amyloidogenicity of the #SARSCoV2 #spike #protein (#S-protein)."

1/5 As many of you here watch family, friends, associates and colleagues living their best lives out there, as #COVID19 surges, please know that many ARE NOT okay.

"Psychoanalyst Judith Alpert theorizes that our culture is terrified of death, illness, and vulnerability." 2/5 "Thus, “[t]hose who have contact with the #chronically #ill . . . do not want to be #reminded of #vulnerability and #ultimate #demise. In turn, the demand placed on the chronically ill is to #control, #hide, and #overcome the #chronic #illness.” (Alpert, 2012)."

1/2 "Here, we demonstrate an increased survival of infected #honey #bee #larvae after their #queen was #vaccinated, compared to offspring of #control #queens (#placebo vaccinated)."

frontiersin.org/articles/10.33… 2/2 "These results indicate that #trans-#generational #immune #priming (#TGIP) in insects can be used to majorly enhance #colony #health, protect #commercial #pollinators from #deadly #diseases, and reduce high #financial and #material losses to #beekeepers"

1/5 "The 2022 WMO/#UNEP #Ozone Assessment contains the most up-to-date understanding of ozone #depletion, reflecting the thinking of hundreds of international scientific experts who contribute to its preparation and review."

#NOAA

csl.noaa.gov/assessments/oz… 2/5 Does anyone with expertise in this area know why charged particles in plasma from #solar #flares, #coronal #mass ejections (#CMEs) and even #localized #thermonuclear #bursts, i.e. #micronovae, were not considered in this report?

1/4 "Researchers from the University of Colorado Boulder found in a 2019 study that the average house is prone to “#indoor #air quality levels on par with a polluted major city.”"

eurekalert.org/news-releases/… 2/4 "Preliminary results from the study show that #air #quality levels were so poor at the end of the study, the researchers had to recalibrate their #sensitive instruments almost immediately."

#indoor #air #quality

1/6 Interesting work from Dr. William Encinosa and colleagues, with #Black #children disproportionately affected...

#complications #adverse #drug #events #costs #disparities #multisystem #inflammatory
#syndrome #MISC #children #COVID19 #LongCovidKids

jamanetwork.com/journals/jaman… 2/6 "Did outcomes vary by the number of organ systems affected in #multisystem #inflammatory #syndrome in #children (MIS-C) in 2021?"

1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."

nature.com/articles/s4159… 2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP). 

#MultipleSclerosis