Discover and read the best of Twitter Threads about #alzheimer

Most recents (24)

21/09 > #Alzheimer : un biomarqueur indiquant une neurodégénérescence identifiée dans l’œil bit.ly/2G1GVfn via @ScienceDaily #LaMethSci
[#Podcast] 2018 > #Alzheimer : année zéro ? bit.ly/2HFdxd4 un #LaMethSci à (ré)écouter via @franceculture !
[L’étude à découvrir] 17/09 > Chaîne légère de neurofilament dans l'humeur vitreuse de l’œil bit.ly/2EqHuPG via @AlzheimersRes #LaMethSci
Read 8 tweets
Today is #WorldAlzheimersDay

#Alzheimer's disease is the most common form of #dementia and may contribute to 60–70% of cases. People with dementia need access to care. Let's ensure the dignity of every person with a #MentalHealth condition is respected

👉bit.ly/2vVsIse
#Dementia is an illness characterized by a deterioration in cognitive function beyond what might be expected from normal ageing.

It is a major cause of disability and dependency among older people 👵👴

👉 bit.ly/2vVsIse

#WorldAlzheimersDay
Reduce your #dementia risk by:
🏃‍♂️ Exercising regularly
🚭 Not smoking
🍺 Avoiding harmful use of alcohol
⚖️ Controlling your weight
🍐 Eating a healthy diet
✅ Maintaining healthy blood pressure, cholesterol & blood sugar levels

👉 bit.ly/2vVsIse

#WorldAlzheimersDay
Read 10 tweets
#Alzheimersday

Aujourd’hui, petit thread informatif sur le travail du #Kinésithérapeute avec un #patient atteint de la #maladie d’#Alzheimer

#TeamKiné
#Alzheimersday

Le #Kiné travaille l’entretien des fonctions d’#équilibre et de #marche du #patient

➡️Exercices aérobics et de coordinations (ex: méthode BIG)
➡️Maintien des capacités de déplacement
➡️Maintien de l’#Autonomie
➡️Limite le risque de #Chute

#TeamKiné
#Alzheimersday

Suite à une sous utilisat’ de certains mouvements des raideurs articulaires/musculaires peuvent apparaître.

➡️ Maintien de la #souplesse des membres
➡️Techniques d’#étirement, #mobilisations spécifiques...
➡️garder une large amplitude de #mouvement

#TeamKiné
Read 5 tweets
Today is #WorldAlzheimersDay 🧠 and this disease has been on #IRBBarcelona's agenda since its start.

@Eduard_puig is one of the committed scientists who recently made an important contribution to the field.
(1/4)
In June, @Eduard_puig, @SoniaCiudad and Natalia Carulla, among others, revealed the specific ensembles of Aβ protein that have the capacity to disrupt the membrane of neurons, causing their death.

➡️bit.ly/3clhW34
#IRBScience #WorldAlzheimersDay
(2/4)
In fact, the @ShorterLab, one of the 🔝groups in protein aggregation, published a review on their work in @TrendsNeuro.

➡️cell.com/trends/neurosc…
#WorldAlzheimersDay
(3/4)
Read 4 tweets
Ensuite, et Dieu que ce fut douloureux... il a bien fallu rendre ton appartement.
3 mois de cartons, le cœur au bord des yeux, à trier ta vie.
A vider, sans te le dire, pour te protéger, ta maison. Là où j’avais grandi. #Alzheimer 2/2
3 mois d’un nouveau marathon. Cartons, sacs, garde-meubles, déchèterie, le bon coin...
Ça m’a valu une névralgie. Codéine et cortisone, la somatisation d’une victime collatérale.
Ton appartement, je l’ai rendu le 31 décembre 2018.
Depuis, une partie de mon cœur est à Garches. Avec toi, et la magnifique équipe qui t’entoure, dans ton Ehpad.
Read 9 tweets
Alzheimer... 9 lettres, un mot et un mal qui m’ont enlevé quelqu’un qui m’était précieux, très précieux.
Ma mère.
Car oui, c’est le propre de cette pute de maladie : tu peux perdre quelqu’un de son vivant.
Thread (1/2, pas mal de choses à dire)👇🏻
#Alzheimer
Ça a commencé il y a 4 ans. 4 ans seulement...
Des absences, des pertes d’équilibre, quelques rendez-vous ratés. 1ers signes, aussitôt repérés, aussitôt ignorés.
Parce que ces 9 lettres, elles font tellement peur que tu ferais tout pour te raccrocher à autre chose. Pour expliquer autrement tout ce bordel.
Les mains sur les yeux, surtout ne pas voir...
Sauf que le monstre, il est déjà là. Dans ta tête, maman, et petit a petit, dans ma vie.
Read 25 tweets
Un hilo sobre la incidencia y últimos avances terapéuticos en la Enfermedad de #Alzheimer.
Un alto en el camino de la pandemia que nos afecta, para poner luz en una de las enfermedades más terribles desde un punto de vista sanitario, personal, social y económico.
1. IMPACTO PROYECTADO
Un total de 131 millones de enfermos para 2050 a nivel mundial y un coste asociado (sanitario+social) cercano a los 2 billones de dólares en 2030. Prevenir, retrasar o detener la enfermedad son retos científicos de este siglo XXI.
ENSAYOS CLÍNICOS EN MARCHA
Hay 121 agentes terapéuticos en ensayos clínicos para abordar la enfermedad de Alzheimer:
- 29 fármacos en fase III
- 65 fármacos en fase II
- 27 fármacos en fase I
Read 7 tweets
Un nuevo biomarcador en saliva que puede facilitar el diagnóstico del #Alzheimer. Sencillo, sensible y específico de la enfermedad. Un avance que esperamos ayudará a centenares de miles de pacientes. geroa.net
ncbi.nlm.nih.gov/pmc/articles/P… Image
Resulta específico de la enfermedad de Alzheimer. Tan solo con una muestra de saliva, y una sencilla medición, muestra un comportamiento riguroso a la hora de detectar aquellos con la enfermedad. Nuestro último trabajo con Valentín Fuster.
thelancet.com/journals/ebiom…
Un momento clave en el que la La FDA (agencia americana) acepta la evaluación prioritaria del fármaco Aducanumab (Biogen) para la enfermedad de #Alzheimer. De aprobarse sería el primer producto que cambiaría el curso de la enfermedad. El diagnóstico será más clave que nunca.
Read 4 tweets
Mi resumen científico de la segunda semana de Agosto (8 al 14) sobre la #COVID19 y el coronavirus.
Un hilo con 10 noticias.
1. Los super-eventos de contagio dependen de 3 factores:
➡️QUIEN: Solo un 10-20% de los infectados serían super-contagiadores
➡️CUANDO: Pico máximo de infectividad (1-2 días tras infectarse). ➡️ DONDE: Lugares cerrados, concurridos y mal ventilados.
2. La empresa Moderna (vacuna ARN) anuncia un precio de 32-37 dólares por dosis para pedidos pequeños (millones de dosis). Entiendo el esfuerzo en I+D, pero sabiendo que han recibido 1000 millones de la administración, el precio me parece abusivo.
Read 12 tweets
On #WorldBrainDay, the Neuronet programme is celebrating @IMI_JU's public-private partnerships in #neurodegeneration research; from fundamental science to clinical studies, data analysis to knowledge mining & beyond.

Keep your eyes peeled! #WeAreNeuronet
2/20 @bwfalcon, now a group leader at @MRC_LMB, worked on the structure of Tau filaments @imprind, showing how they are misfolded in the brains of people with #neurodegenerative diseases.

Read about his work here: bit.ly/IMPRIND-falcon #WorldBrainDay
3/20 #WorldBrainDay 2020 is dedicated to raising awareness of #Parkinsons disease. There are currently no disease-modifying treatments for mild cognitive impairment in PD; the #PD-MIND project aims to test a new drug to treat this condition. Find out more:bit.ly/PD-MIND
Read 21 tweets
La magnitud del problema de la demencia y el #Alzheimer debe ser considerado globalmente. Las sociedades envejecen y el tratamiento de los/las enfermas, así como los gastos médico-sociales ligados a la enfermedad van a constituir uno de los grades desafíos en los próximos años.
El diagnóstico de los pacientes con #Alzheimer resulta indispensable al igual que pasa con el #SARSCoV2. Cuanto antes se haga un diagnóstico diferencial antes de podrá abordar la situación del paciente con medicamentos y métodos no farmacológicos.
Un artículo estudia el impacto económico asociado a extender el uso de pruebas diagnósticas convencionales (PET y LCR) en pacientes con deterioro cognitivo leve (un episodio previo al #Alzheimer). Son pruebas invasoras y tienen un importante coste para los sistemas sanitarios. ImageImage
Read 3 tweets
Ever wondered if and how #recombination of #retroelements contributes to #somatic #mosaicism? Read about it in our new pre-print:

Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110…
1/ Background: pathogenic non-allelic homologous recombination (NAHR) of Alu and LINE-1 has been found in several genomic disorders and #cancer types. We thought this could be just the tip of the iceberg of a physiological recombinogenic activity of retroelements.
2/ The excellent Martin Frith developed a fresh pipeline to identify non-allelic homologous recombination (NAHR) in short and long-reads libraries: 🦖TE-reX🦖. It smartly focuses on split reads that join repeat elements at homologous positions.
Read 11 tweets
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Read 6 tweets
Check out the latest preprint from the lab on "Integration of #Genomic & Multi-tissue #proteomic data in neurodegenerative diseases" lead by @chengran2020 @WUSTLdbbs in @ccrugom lab at @WUSTLmed supported by @cziscience via @medrxivpreprint medrxiv.org/content/10.110… #tweetorial ⬇️
This is the first #proteomic study that uses high throughput pQTL in neurological relevant tissues to identify novel genetic loci regulating protein levels, which will improve our understanding of the biology of #Alzheimers, #Parkinsons, & other neurodegenerative diseases
We identified hundreds of novel pQTLs in CSF, plasma, & Brain linking novel genes, biomarkers and drug targets with #Alzheimers, #Parkinsons
Read 10 tweets
Daily Bookmarks to GAVNet 6/16/2020-2

greeneracresvaluenetwork.wordpress.com/2020/06/16/dai…

Capitalism's Case for Abolishing Billionaires - Evonomics

evonomics.com/capitalism-cas…

#billionaires #capitalism
Using Evolutionary Social Science to Deal with Pandemics - Evonomics

evonomics.com/responding-to-…

#social #coronavirus #evolutionary #complexity
Petroyuan’s stature grows on Shanghai exchange, helping world’s largest energy importer cut dependence on US dollars | South China Morning Post

scmp.com/business/china…

#petroyuan #oil #energy
Read 6 tweets
Daily Bookmarks to GAVNet 5/17/2020-2

Coronavirus has made basic income not just desirable but vital | World Economic Forum

weforum.org/agenda/2020/04…
#Income #UBI #basic
The Invisible Business Risk of the Covid-19 Pandemic | naked capitalism

nakedcapitalism.com/2020/05/the-in…
#pandemic #coronavirus #capitalism #risk
Read 8 tweets
Good Day 🌎! Are you ready for one of Gods🌿to be Federally Legalized? I have stood strong on this since #DJT announced he would run in 2015. Follow along for my thoughts and leave a comment below. Please retweet and lets help those who need it most. #WWG1WGA
2) Starting off we know the issues with his brother and #Alcohol which for most would lead them to believe he was completely against any and all substances. However I am lead to believe the exact opposite.
3) #Drugs and #Alcohol both are known to have horrible side effects that contribute to many of the horrible #sickness and #disease we know today. We have all long known the power of this 🌿. This leads me to a Poll, Lets keep you engaged!
Read 18 tweets
It is two months to the publication of @lisabortolotti's The Epistemic Innocence of Irrational Beliefs (@OUPPhilosophy) and we will tweet a weekly quote from it to get you interested... buff.ly/2Xokxnb #EpistInnocence2020 /1
"The core idea is a provocation: what if some epistemically irrational #beliefs have a role to play in securing active engagement with our surrounding physical and social environment, and can help restore such an engagement after a critical disruption?" #EpistInnocence2020 /2
"We should make room for the possibility that the reporting of distorted #memory beliefs is for the person with #Alzheimer’s disease a means to averting a breakdown in epistemic functionality at a critical time." #EpistInnocence2020 /3
Read 13 tweets
I study the illness #ME/CFS - a neuroinflammatory condition that usually begins w/ a #viral infection (sometimes a #respiratory infection!). I have argued for years that infecting #pathogens tied to the illness might persist in the central nervous system (CNS) of such patients
2/ While I realize this article is talking about acute #infection and #COVID19 - it explains that #SARS-CoV-2 “might infect neurons, raising questions about whether there could be effects on the brain that play a role in patients’ deaths:”
the-scientist.com/news-opinion/l…
3/ Matt Anderson, (one of my favorite Beth Israel pathologists!) states, “Some of the purely respiratory symptoms that you might attribute to the #disease, the inability to get air into the #lungs, might actually be defects in #respiration controlled by the #nervous system.”
Read 8 tweets
Hay mucha gente que lo está pasando mal, sin duda; pero hay un colectivo casi olvidado: los cuidadores de un paciente con Demencia encerrados día y noche en casa.
Voy a intentar dar algunos consejos...
#Alzheimer
#Demencia
#YoMeQuedoEnCasa
#EsteVirusLoParamosUnidos
Quizás la primera recomendación es intentar generar una rutina diaria y todos los días a cumplirla. Especialmente horarios de comidas y periodo de sueño, incluyendo las visitas al cuarto de baño e higiene personal.
#Alzheimer
#Demencia
#YoMeQuedoEnCasa
Intente hablar con calma, usando frases simples y que incluyan solo una o dos ordenes. Esto es fundamental para aquellos pacientes que tienen problemas de lenguaje.
(En los informes de su médico suele poner "afasia progresiva" o "disfasia")
#Alzheimer
#Demencia
#YoMeQuedoEnCasa
Read 11 tweets
@DrShawnL Hey - b/c they have shown that amyloid beta appears to actually be an antimicrobial peptide that - at least in the lab/mice - forms in response to a range of bacterial, viral + fungal pathogens capable of persisting in the CNS, including the herpesviruses: ncbi.nlm.nih.gov/pmc/articles/P…
@DrShawnL 2/ Related studies by team’s like @G_Tetz support their findings. Here Tetz found that, in the lab, Tau formation may be additionally promoted by DNA from bacterial pathogens like Borrelia: nature.com/articles/s4159…
@DrShawnL @G_Tetz 3/ Meanwhile herpesviruses have been identified in human Alzheimer’s autopsied brains + shown capable of driving neuroinflammation (cell.com/neuron/pdfExte…) So has oral pathogen p. gingivalis and the toxic gingipains proteins it produces (advances.sciencemag.org/content/5/1/ea…)
Read 7 tweets
One step closer to blood biomarkers for #Alzheimer! Two independant papers out in @NatureMedicine today, from us & @biofinder_study.
@EHThijssen tested the diagnostic properties of plasma Ptau181 using lots of data from @UCSFmac. nature.com/articles/s4159…

Illustrated summary ⬇️!
1) Ptau181 is elevated in patients with a clinical Dx of Alzheimers, compared to controls and syndromes associated with frontotemporal lobar degeneration
2) Using PET to detect amyloid deposition, @EHThijssen showed that Ptau181 differenciates amyloid-positive from negative cases: AUROC=.92 in 185 patients, .94 in MCI (n=39), and .88 in controls (n=40)
Read 9 tweets
Y lo peor: son enfermos de la variedad genética, tratados antes de que empiecen los síntomas #Alzheimer
Os hablé de esta variante de la enfermedad aquí: jotdown.es/2015/09/la-mut…
Read 5 tweets
Why memories of music cannot be lost to #Alzheimer's and dementia
» weforum.org/agenda/2019/03…
Especially into a piece of music, brain does something called Autonomous Sensory Meridian Response (#ASMR) which feels to you like a tingling in your brain or scalp.
Turns out that #ASMR is pretty special. According to a recently published study in The Journal of Prevention of Alzheimer's Disease (catchy name!), the part of your brain responsible for ASMR doesn't get lost to #Alzheimer's and dementia. #Neuroscience
» en.wikipedia.org/wiki/Autonomou…
Sir Paul McCartney believes in the ’healing power’ of music.
» irishcentral.com/opinion/amyand…
"All it is, its little vibrations reaching your heart. Music, you know, it's only little vibrations, little words and little things, but it has this powerful effect."
Read 8 tweets

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