Discover and read the best of Twitter Threads about #alzheimer

Most recents (5)

#Cuivre épisode 2 c'est parti.
Rappel du premier épisode :… après un peu de chimie et de #reglementation on va rentrer dans le vif du sujet #toxicologie.
D’ailleurs, je m’aperçois que je suis allé un peu vite dans ma démarche.
Petit rappel sur l’évaluation des risques :
Préliminaire, différence entre dangers et risques, je la fais tout le temps celle là mais il faut bien comprendre. #danger : propriété intrinsèque d’une substance, #risque : probabilité d’être exposé à cette substance.
Donc risque = Danger x exposition.
Ceci étant dit : la démarche d’évaluation des risques :
1 – Identification des dangers (par les études, publications, etc…)
2 – Caractérisation du danger : dérivations des doses de références toxicologiques
Read 35 tweets
Qué manos más suaves tienes mamá, cómo me mimas, cómo me acaricias, cómo me besas… ¡Y qué bien hueles! Me parece que es la primera vez que te veo, aunque te oigo y es como si te oyera desde siempre. Y el señor de las barbas… ¡también me suena su voz! #HiloDeNochebuena
Dicen que hoy es un día especial, y yo no sé muy bien por qué, pero este sitio se ha llenado de gente. La puerta no para de sonar y cada uno que entra forma una fiesta.
¡Qué ruido, qué jaleo, qué alegría tienen!
Read 57 tweets
1/ In case we needed more reasons for building better cities, the evidence is growing that #mentalhealth is significantly affected by #urbanplanning and #urbandesign ... whether for the better or the worse is up to us ...
2/ Exposure to natural light is linked to better sleep, reduced stress, and better work/school performance A well-designed city ensures access to natural light on sidewalks, in public spaces, and inside homes and offices.
3/ Boring streetscapes, with monotonous, feature-less facades and lack of sensory stimulation, can increase sadness, addiction and disease-related stress
Read 9 tweets
So @Merck’s BACE-1 inhibitor Verubecestat resulted in “near-maximal reduction” of amyloid-beta in cerebrospinal fluid and “modest reduction” in brain amyloid. But it didn’t help even #Alzheimer’s disease, even "mild" Alzheimer's. A few thoughts:
1. Many companies are holding on to the hope that giving #tau- and #amyloid-busting drugs earlier, before Alzheimer's sets in, could prevent the disease. The FDA might even be open to using tau and amyloid as biomarkers to approve #Alzheimers drugs…
2. But if we already know these drugs can lower amyloid-beta levels and *not* stop disease progression, is that really a good idea? I'd love to see the long term studies done, but the idea of drug approval based on biomarkers, and not cognitive markers, seems like a can of worms.
Read 5 tweets
Today is World #Alzheimer's Day.
Alzheimer's disease is the most common cause of #dementia & may contribute to 60–70% of cases
#Dementia is a major cause of disability among older people
There are nearly 10 million new cases of #dementia every year - that's one case every 3 seconds
Read 9 tweets

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