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Hey @DaveKeto & @siobhan_huggins, This paper links Atherosclerosis with metabolically induced monocyte dysfunction.
ncbi.nlm.nih.gov/pmc/articles/P…
Could #Keto, even with very high LDLc, be non-Atherosclerotic due to metabolic grooming of 'well behaved' monocytes and macrophages?
ncbi.nlm.nih.gov/pmc/articles/P…
Could #Keto, even with very high LDLc, be non-Atherosclerotic due to metabolic grooming of 'well behaved' monocytes and macrophages?
In other words, could 'hyper-responders' (as defined at cholesterolcode.com) be benefiting from metabolically induced changes at the monocyte and macrophage level, where those cells are no longer 'hyper responding' to chemokines.
This paper found 2.6 and 9.8 fold increase in macrophage recruitment from moderate and severe metabolic stress in LDL receptor-deficient mice over a non stressed baseline. The degree of macrophage recruitment correlated to atherogenic Leison progression.
ahajournals.org/doi/pdf/10.116…
ahajournals.org/doi/pdf/10.116…
