Thread by @LindaWhaley

Day 3 #LowCarbSeattle @FatEmperor Ivor Cummins is up soon! His topic is "Lifespan & Healthspan: Evading Modern Chronic Disease"

@lowcarbusa @LCPamDevine @DougieReynolds

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds Ivor's Dad died with dementia. He is talking about how long we should live and thrive. The graph shows different paths folks can generally end up on. @tednaiman will most likely end up on the longest path, but poor choices or genetics can affect which path you are on.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman CVD starts with an atheroma, then continued bad choices you'll get calcium deposits, more atheromas, until... MI!!!oices.

Go back BEFORE the MI and look to see what is happening in your arteries with a CAC. This can help you make better choices. Know your score.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman CAC is a bigger risk factor than age.

ihda.ie wants folks in Ireland to know their CAC.

Study showed over 5yrs stabilization will mean a better outcome with a bad CAC over the years.

"Cereal Killers" producer made a documentary and movie for Ivor.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman The men they test in the documentary had been given good health scores by their doc, but many had problems and several needed immediate health intervention.

TOFI people do not expect the dx of heart issues, but they too need to understand their risk.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman Root causes not LDL. Input Chol 300, LDL 190 50yo male into a cardiology risk calculator, came out as low risk.

High Trg/HDL huge risk

Tot Cho High LDL not an indicator High BP risk, High insulin Bigger risk.

Particles? No. ApoB/LDLp needs alot to happen for that to be issue.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman Different layers in the artery wall, different levels of oxidized LDL, glycocalyx can contribute in particle issue, endothelial cell with a few different processes that can happen at this level, but it is what is driving the process, not the process, Inflamm, BP, BG

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman Skipping Proteoglycans and moving to HDL healthy levels = lower risk. HDL goes through the artery wall at the SRB1 to remove LDL from your artery wall. Makes sense that oxLDL is what needs to be removed. More research needs to be done.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman Lipomyopia - only concentrating on LDL as the important lipid. :-)

High CAC did better over time with medicine intervention over time, but lower CAC did not.

IR, High BG, High BOP, Inflamm all drivers.

Media articles with scare tactics about Keto makes it hard to get msg out.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman Many illnesses related to IR, but med community focus on LDL.

Low fat did not improve health but KETO/LC does.

@virtahealth huge study showing KETO very effective.

Patient with APOE e4 the door to insulin resistant dyslipidemia and brain fog improved on KETO. Jan 2019 study

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth Epilogue - focus on IR, High BP, High BG, Inflammation, eat Keto, nutrient density, remove bad foods, processed foods, seed oils, vitamin D, exercise for metabolic health. Put it all together you could end up looking like @tednaiman :-)

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth We are the dead poem. Powerful comparison with war "Flander's Fields" to think of those who died of diseases/conditions that could have lived longer living with KETO.

End. Q&A
- Are LDL particles acting like an immune cell and endothelial cell...something sciency from @DaveKeto

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth @DaveKeto Ivor says it may be possible, but not totally going in that direction. Mentions cholesterol deniers. Different than statin deniers. Chol deniers are people that question chol model
- Arresting CAC drivers improves risk does not exist inh orthodox medicine and may be hard to do.

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth @DaveKeto - NMR Quest Lab can break out HDL particles. Lipo IR great measure.
- Couldn't get Insulin on footballers in documentary because of delivery conflicts.
- Risk calculators used - AHA, Qrisk3-2018 (european), Framingham Coronary Disease Risk Score, Astro-CHARM (best), Mesa

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth @DaveKeto - Engineers could be beneficial for future study, but needs funding. Probably need bio-engineers and tops in their fields.
- CAC patients worry about radiation. CIMT not a good risk test, CAC better.
- Eating LC as e3/4 or e4/4 with caveat - some sensitive to cheese/animal pro

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth @DaveKeto May be cheese.
- ACC/AHA risk calculator LDL is a dead box on that calculator.

Here's what you are missing when you don't go to one of these @lowcarbusa conferences:

"Engineer to Engineer, what's the mechanism?" @DaveKeto to @FatEmperor

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth @DaveKeto Thank you, Ivor, @FatEmperor on a fascinating presentation and great Q&A session. Thank you!!!

@FatEmperor @lowcarbusa @LCPamDevine @DougieReynolds @tednaiman @virtahealth @DaveKeto .@threadreaderapp unroll please