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I have some thoughts on a recent video posted at NutritionFacts.org by @nutrition_facts called “Keto Diet Results for Weight Loss” that relied heavily on our research to criticize ketogenic diets: nutritionfacts.org/video/keto-die…
The video cites our 2015 @Cell_Metabolism paper that didn’t investigate a keto diet. We even refused to call the diet “low carb” because the calorie restriction achieved by selectively cutting carbs resulted in a diet ~30% of total calories from carbs. ncbi.nlm.nih.gov/pubmed/26278052
Our study was NOT an efficacy study as portrayed in the @nutrition_facts video. Rather, it was designed to investigate the physiology of selective restriction of carbs vs fat &the effects on insulin secretion and body fat. The body fat differences were clinically meaningless!
Similarly meaningless body fat differences were found in our cited meta-analysis investigating *controlled feeding studies* employing isocaloric manipulations of diet carbs:fat while keeping protein constant as published in our 2017 @AGA_Gastro review: ncbi.nlm.nih.gov/pubmed/28193517
Plenty of randomized diet trials *that did not control food intake* have shown that lower fat diets result in similarly disappointing long-term weight and body fat loss vs lower carb diets. If anything, there’s a slight benefit of lower carb diets. ncbi.nlm.nih.gov/pubmed/26527510
While diet differences often dissipate over the long term, early on people randomly assigned to low carb diets seem to be able to cut more calories and lose more weight than those assigned to a low fat diet: ncbi.nlm.nih.gov/pubmed/30672127
That’s why we our latest research has turned to studying ad libitum food intake in diets varying widely in carbs:fat (clinicaltrials.gov/ct2/show/NCT03…) whereas our past studies focused on energy expenditure, fat oxidation, and body fat differences during isocaloric controlled feeding.
Besides body weight and fat loss, low carb diets likely have other advantages compared to high carb diets when it comes to glycemic control and insulin secretion as we recently reviewed here: ncbi.nlm.nih.gov/pubmed/29677013
