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The #CRISPR human genome editing review I've been waiting for, from/by Jennifer @doudna_lab @nature nature.com/articles/s4158…
@doudna_lab @nature When you're really great in academics, you have 7 superscripts, and everybody wants to claim you :-)
@UCBerkeley
@berkeleyMCB
@QB3
@HHMINEWS
@igisci
@GladstoneInst
@LBNLBioSci
@UCB_Chemistry
@BerkeleyLab
@doudna_lab @nature @UCBerkeley @berkeleyMCB @QB3 @HHMINEWS @igisci @GladstoneInst @LBNLBioSci @UCB_Chemistry @BerkeleyLab "This profound opportunity to change #healthcare
for many people requires scientists, clinicians and bioethicists to work with healthcare economists and regulators to ensure safe, effective and affordable outcomes. The potential impact on patients
is too important to wait."
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Eric Topol
@EricTopol
We need new antibiotics to counter resistance. Now @MITdeptofBE's James Collins,@BarzilayRegina @ItsJonStokes @MIT_CSAIL @WyssInstitue, @broadinstitute & team have trained a
#deeplearning #AI model to help the path of discovery
cell.com/cell/fulltext/…
@CellCellPress @AIHealthMIT
@MITdeptofBE @BarzilayRegina @ItsJonStokes @MIT_CSAIL @broadinstitute @CellCellPress @AIHealthMIT @CellPressNews When there's any report about an #AI and drug discovery effort, my "go to" is @Dereklowe for perspective.
When he says "So overall, this is an impressive paper," it has gravitas:
blogs.sciencemag.org/pipeline/archi…
@MITdeptofBE @BarzilayRegina @ItsJonStokes @MIT_CSAIL @broadinstitute @CellCellPress @AIHealthMIT @CellPressNews @Dereklowe "The study is remarkable, says Jacob Durrant @LabDurrant ... The team didn’t just identify candidates, but also validated promising molecules in animal tests."
nature.com/articles/d4158… @NatureNews by @JoMarchant May be the best #AI-drug story yet, especially for unmet need.
Read 3 tweets
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Eric Topol
@EricTopol
The field of #cancerneuro is exploding.
The cancer-neuronal crosstalk that is promoting tumor growth.
Just look at today's and another recent @nature cover
Key papers:
nature.com/articles/s4158…
nature.com/articles/s4158…
@nature More on #cancerneuro:
1. Startups addressing it
nature.com/articles/s4158… @NatureBiotech @ElieDolgin
2. Dangerous liaisons nature.com/articles/d4158… @NatureNV
3. Tumor cells manipulating synapses
nature.com/articles/d4158…
4. Loss of p53
nature.com/magazine-asset…
@nature @NatureBiotech @ElieDolgin @NatureNV anybody have a better hashtag than #cancerneuro for this?
Read 3 tweets
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Eric Topol
@EricTopol
Can a Mediterranean #diet (vs controls) in people age 65-79 promote cognitive function, less frailty & markers of inflammation? A gut #microbiome assessment w/ #AI ML
gut.bmj.com/content/early/… @Gut_BMJ #openaccess by @ghosh_tarini @UCC and colleagues @Pharmabiotic @APCMicrobiome
@Gut_BMJ @ghosh_tarini @UCC @Pharmabiotic @APCMicrobiome Correct 1st author is @tarini_ghosh
@Gut_BMJ @ghosh_tarini @UCC @Pharmabiotic @APCMicrobiome Another new #diet 10-year study of heart disease risk, centered on plasma TMAO, a gut #microbiome metabolite, points toward advantage of hi vegetable and low animal fat, red meat (w/ the usual caveats)
onlinejacc.org/content/75/7/7…
onlinejacc.org/content/75/7/7…
@paheidenreich
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paulmuaddib61
@paulmuaddib61
#CRISPR #UniversalFluVaccine PART 1⃣ #AdaptiveImmuneSystem #TheSleeperHasAwakened Here are the "extras" in the vaccines. "Gene editing by exploiting the molecular components of the CRISPR bacterial adaptive immune system" sbgridconsortium.tumblr.com/post/183627174…
#CRISPRCas9 #UniversalFluVaccine PART 2⃣ #AdaptiveImmuneSystem #TheSleeperHasAwakened
CRISPR-Cas: microbial #AIS characterized by inserting short viral-or plasmid-derived DNA fragments (spacers) into the CRISPR regions in the microbe’s chromosome. nature.com/articles/s4159…
#CRISPRCas9 #UniversalFluVaccine PART 3⃣ #AdaptiveImmuneSystem #TheSleeperHasAwakened
genengnews.com/insights/novel…
Read 3 tweets
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Ewan Birney
@ewanbirney
New year's day is a time for reflection and I've been thinking about where I - and the field - has come from scientifically and what happens next.
I am very lucky in lots of ways, but in genomics I started lucky and young: in 1991, a lanky haired boy of 19, I taught myself to code to explore this new-fangled large scale database called "Expressed Sequence Tags" large scale (at that time) DNA database, now considered puny.
A postdoc in Rich Robert's group, Sanjay Kumar, gave me a copy of Kernighan and Ritchie programming in C, I got access to the VAX (!) machine at CSHL and then at ICRF in London and the venerable GCG software to develop my first program to compare profile HMMs to DNA directly
Read 45 tweets
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Alexis Verger
@Alexis_Verger
#365papers Let's try this for 2019, highlighting 365 papers (does not necessarily mean 1 paper per day) - A thread
#365papers 1⃣ The thread started with a bang - A must read opinion by @MarcHalfon on the fundamental question of how to define an enhancer cell.com/trends/genetic…
#365papers 2⃣ citrullination by PADI2 of RNA Pol II CTD R1810 regulates the transcription of highly expressed genes by mediating the interaction with P-TEFb cell.com/molecular-cell…
Read 367 tweets
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Gaetan Burgio
@GaetanBurgio
So let's comment on these reports that came out today on the creation of the first #CRISPR babies from a team at Shenzhen, China reported here -> technologyreview.com/s/612458/exclu… or here -> apnews.com/4997bb7aa36c45… and this Youtube video
What we know about it? Well not much. 1/ They have edited CCR5 gene, which prevent HIV entry. Have they edited CCR5 to generate a ∆32 mutation? no idea. It looks they edited CCR5 in the pronuclear and check editing by sequencing 3-5 days later -> 16/22 edited and 11 implanted
Twins were born with one carrying an heterozygous allele and the second baby an homozygous allele and one carried mosaic alleles. Details? No off target found but I don't have any details on this too. Are the CCR5 protein level changed? Again very little details on this.
Read 10 tweets

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