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The field of #cancerneuro is exploding.
The cancer-neuronal crosstalk that is promoting tumor growth.
Just look at today's and another recent @nature cover
Key papers:
nature.com/articles/s4158…
nature.com/articles/s4158…
@nature More on #cancerneuro:
1. Startups addressing it
nature.com/articles/s4158… @NatureBiotech @ElieDolgin
2. Dangerous liaisons nature.com/articles/d4158… @NatureNV
3. Tumor cells manipulating synapses
nature.com/articles/d4158…
4. Loss of p53
nature.com/magazine-asset…
@nature @NatureBiotech @ElieDolgin @NatureNV anybody have a better hashtag than #cancerneuro for this?
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Eric Topol
@EricTopol
There's been a lot of claims and hype on #AI-> drug discovery. Here's my summary of the 4 recent reports/candidates; the antibiotic is the most impressive to date. 2 are unpublished.
The antibiotic effort essentially started from scratch and led to a highly promising molecule using deep neural networks cell.com/cell/fulltext/… one of our most important unmet needs in medicine
More on this at the time of publication (20 Feb 2020)
Read 3 tweets
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Eric Topol
@EricTopol
Linking a bacterium genotoxin and colon #cancer for the 1st time in organoids, and the mutational signature in validated in affected patients @nature @HansClevers @Cayetanopm @_Hubrecht nature.com/articles/s4158…
@nature @HansClevers @Cayetanopm @_Hubrecht Such an important smoking gun for the gut #microbiome's potential contribution to cancer, just as we've recently seen it's ability to protect from cancer
nature.com/articles/s4156… @NatureMicrobiol
@nature @HansClevers @Cayetanopm @_Hubrecht @NatureMicrobiol Watch this gut #microbiome and #cancer space.
It looks like we're just scratching the surface
nature.com/articles/s4156…
nature.com/articles/s4156…
@NatureRevCancer
@EranElinav
Read 4 tweets
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Eric Topol
@EricTopol
"I don't think it is inevitable"—@POTUS
That's because I'm a genomic genius and Americans are protected by the MAGA gene.
@POTUS @NewYorker @BillBramhall
@POTUS @NewYorker @BillBramhall "This is their new hoax" —@POTUS
westernadvocate.com.au/story/6655260/…
Beyond belief #COVIDー19
Read 3 tweets

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Chris Tape
@christophertape
Extremely proud to share my lab’s first paper: ‘Cell-Type Specific Signaling Networks in Heterocellular Organoids’ out today in @naturemethods (1/14) nature.com/articles/s4159…
#Organoids are amazing biomimetic tissue models that contain multiple cell-types (e.g. stem, differentiated), each in their own cell-state (e.g. proliferating, quiescent, apoptotic). (2/14)
While this complexity is what makes organoids so useful, it also makes them tricky to study. My lab wanted to use organoids to study cell-signalling in cancer – but bulk methods (e.g. LC-MS/MS) couldn’t easily provide cell-type and cell-state specific signalling data. (3/14)
Read 14 tweets
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Ashley Laughney
@LaughneyLab
(1/n) Delighted to share our work using #scRNAseq to explore the intersection between regeneration, development and #immune recognition in #cancer #metastasis online @NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague
nature.com/articles/s4159…
@NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague (2/n) human primary #lungcancer is characterized by the emergence of regenerative cell types, typically seen in response to lung injury, but showing striking lineage promiscuity (identity confused!)
@NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague (3/n) #metastasis exhibits a continuum of more primitive stem to epithelial progenitor states – driven in large part by key embryonic and lung-specifying transcription factors, SOX2 and SOX9.
Read 11 tweets
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Eli Van Allen
@VanAllenLab
A brief thread on our latest study, as well as a more general chat on biology & biomarkers for cancer immunogenomics - w/ longtime friend Dirk Schadendorf + rockstar jr faculty @dliu_ccb + more friends! @NatureMedicine @DanaFarber @broadinstitute
nature.com/articles/s4159… [1/n]
Many current biology & biomarkers blurry lines in cancer immunogenomics - e.g. our TMB melanoma work:

2014-15: Correlation btwn TMB + clinical benefit to ICB in melanoma → neoantigen biology

Though our 2015 data (ncbi.nlm.nih.gov/pubmed/26359337) suggested weak predictive effect...
...and then:

2018: TMB confounded by mutational signatures (ncbi.nlm.nih.gov/pubmed/30150660)

Here: TMB also confounded by histologic subtype

Cool biology: Yes!
Clinical biomarker: Err...probably not
Read 14 tweets
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Ashley Love Sumrall, MD, FACP
@AshleySumrallMD
🚨Tweetorial: NTRK 101 🚨Given the data discussed at @asco #ASCO2019 & @sno #SNO2019 on #NTRK fusions in primary brain tumors & brain mets, I thought we could review the background of these fusions, how to find them, and then look at potential options for tx. #btsm
<Disclaimer: I’m a speaker for Bayer (larotrectinib) and a subI for the STARTRK trial using entrectinib. I also have ongoing research work w @carisls > I’m keeping this as bias-free as possible though. Ok, next...
With the increase in tumor profiling & expanded options using #RNAseq, it seems like it is getting easier to find an #NTRK fusion. It can easily feel like Christmas when you do! 🎄 Just remember that an #NTRK MUTATION is not 🚫 fusion. They aren’t = & treatments aren’t the same.
Read 26 tweets

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