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Can a Mediterranean #diet (vs controls) in people age 65-79 promote cognitive function, less frailty & markers of inflammation? A gut #microbiome assessment w/ #AI ML
gut.bmj.com/content/early/… @Gut_BMJ #openaccess by @ghosh_tarini @UCC and colleagues @Pharmabiotic @APCMicrobiome
@Gut_BMJ @ghosh_tarini @UCC @Pharmabiotic @APCMicrobiome Correct 1st author is @tarini_ghosh
@Gut_BMJ @ghosh_tarini @UCC @Pharmabiotic @APCMicrobiome Another new #diet 10-year study of heart disease risk, centered on plasma TMAO, a gut #microbiome metabolite, points toward advantage of hi vegetable and low animal fat, red meat (w/ the usual caveats)
onlinejacc.org/content/75/7/7…
onlinejacc.org/content/75/7/7…
@paheidenreich
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More from @EricTopol see all

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Eric Topol
@EricTopol
There's been a lot of claims and hype on #AI-> drug discovery. Here's my summary of the 4 recent reports/candidates; the antibiotic is the most impressive to date. 2 are unpublished.
The antibiotic effort essentially started from scratch and led to a highly promising molecule using deep neural networks cell.com/cell/fulltext/… one of our most important unmet needs in medicine
More on this at the time of publication (20 Feb 2020)
Read 3 tweets
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Eric Topol
@EricTopol
Linking a bacterium genotoxin and colon #cancer for the 1st time in organoids, and the mutational signature in validated in affected patients @nature @HansClevers @Cayetanopm @_Hubrecht nature.com/articles/s4158…
@nature @HansClevers @Cayetanopm @_Hubrecht Such an important smoking gun for the gut #microbiome's potential contribution to cancer, just as we've recently seen it's ability to protect from cancer
nature.com/articles/s4156… @NatureMicrobiol
@nature @HansClevers @Cayetanopm @_Hubrecht @NatureMicrobiol Watch this gut #microbiome and #cancer space.
It looks like we're just scratching the surface
nature.com/articles/s4156…
nature.com/articles/s4156…
@NatureRevCancer
@EranElinav
Read 4 tweets
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Eric Topol
@EricTopol
"I don't think it is inevitable"—@POTUS
That's because I'm a genomic genius and Americans are protected by the MAGA gene.
@POTUS @NewYorker @BillBramhall
@POTUS @NewYorker @BillBramhall "This is their new hoax" —@POTUS
westernadvocate.com.au/story/6655260/…
Beyond belief #COVIDー19
Read 3 tweets

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Gui Ramos M.D.
@GuiRamosMD
A New Year, New Therapies! An #IBD #medtwitter #tweetorial

As a late ring into the New Year, let’s explore Novel #IBD Agents coming to practice!

Our Aims:
1️⃣ Understand the Nomenclature
2️⃣ Revise Currently Available Drugs
3️⃣ Discuss Mechanisms & Adverse Events of Novel Agents
First, do we even know what are we treating ⁉️

Studies 🔬 within each one of these four key elements have unveiled pathways involved in #IBD pathogenesis.

Some of which are amendable for potential therapeutic intervention…
In summary...

It takes a genetically susceptible host 🧬 to be exposed to a specific environmental agent 🦠 that, through a weakened intestinal barrier ⚔️, will lead to an exaggerated Immune activation🔥, responsible for the phenotypes we see in clinical practice!
Read 25 tweets
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Anirban Maitra
@Aiims1742
As the decade draws to a close, here’s a compendium of the major advances in #PancraticCancer over the past ten years. Rather than focus on individual papers, I am highlighting a few big themes.
Please add as needed. Hoping for lots more progress in the coming decade!! #PDAC2020
The top 5 most cited #PancreaticCancer original research papers of the decade are:
1: @NEJM: nejm.org/doi/10.1056/NE…
2: @NEJM: nejm.org/doi/10.1056/NE…
3: @CR_AACR: cancerres.aacrjournals.org/content/74/11/… @PanCAN
4: @nature: nature.com/articles/natur… @ciacobu
5: @nature: nature.com/articles/natur…
While #PancreaticCancer remains a challenging disease to Rx, this decade saw the approval of two 1st line therapies for advanced PDAC:
FOLFIRINOX:
nejm.org/doi/pdf/10.105…
Gemcitabine + Abraxane:
nejm.org/doi/10.1056/NE…
And in 2nd line, Onivyde:
thelancet.com/journals/lance…
Read 16 tweets
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Health Nerd
@GidMK
THAT'S NOT WHAT THE STUDY SAID AT ALL WHAT EVEN IS THIS
The study is here and actually it's really awesome: gut.bmj.com/content/early/…
The study looked at people who have IBS and were already being treated with the most effective known treatments

They randomized these people into three groups: cognitive-behavioural therapy (CBT) by phone, web, or treatment as usual
Read 11 tweets
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🌲 somali pirate 𓀊 𓀍 𓀎
@ReadKaczynski
Thread about the damage caused by female birth control, with studies.

Probably one of the most subtly damaging things an animal can ingest, besides poison/heavy metals, and it's being pissed into water supplies and leaked into the environment en masse across the planet.
ENVIRONMENT:

BC changes the GENES of fish
- low concentrations changer behavior & genetics.
archive.vn/XqPfn

Potent biological effect even at very low levels
- Causes intersex, sterile, males, that produce eggs in testes
archive.vn/Zi2Ri
More extensive list of environmental effects+studies
archive.vn/bPxre (inb4 muh pro-life, check the studies)

On to humans;-

CANCER:

Causes cervical cancer
- Five year usage DOUBLES chances of cervical cancer
thelancet.com/journals/lance…
Read 20 tweets
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Chelsea Polis, PhD
@cbpolis
THREAD

My piece debunking 99.4% stat accepted @Reprod_Health 1.5 mos ago. …tive-health-journal.biomedcentral.com/articles/10.11…

Each day the investigation into Koch's paper (see Ed's note …tive-health-journal.biomedcentral.com/articles/10.11…) lingers on is a day consumers may be misinformed ⬇️/at risk of unintended preg #PushingDaysys
Misinfo spreads quickly on social media. Here's just a few recent @instagram posts parroting the misleading 99.4% Koch/Daysy statistic. Might swifter retraction have stopped the spread of some of this? How many unintended pregnancies might a slow response cause? #PushingDaysys
The misleading 99.4% Koch/Daysy statistic is on @YouTube in many vids like this: .

Some YouTubers like Victoria Zimmerman of @TheFemmeHead have huge followings & have promoted Daysy as highly effective; w/out likely knowing these concerns. #PushingDaysys
Read 9 tweets
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Dr Murphy
@DrMurphy11
If you have an interest in #AI, #HealthTech or #PatientSafety - then please read this evidence based thread which tells the story of @DrMurphy11 & an #eHealth #AI #Chatbot.

Read on, or see single tweet summary here👇0/44
is not a 'nerd'; he's a pretty typical NHS consultant with an interest in #PatientSafety.

On 6th Jan 2017 a tweet about an #eHealth #AI #Chatbot in #NHS trials caught his attention, so he thought he'd take a look. 1/44

Evidence here 👇
Dr Murphy downloaded the @babylonhealth App & tried the #Chatbot with a few simple clinical presentations. It quickly became apparent that the #Chatbot had flaws, raising the question if the App had been validated as a triage tool?

As evidenced by👇 2/44
Read 45 tweets

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