@the_Node @SCICambridge excited to still share a quick summary of my would be presentation! #BSDBGenSoc2020
🙂
1/n
🙂
1/n
@the_Node @SCICambridge 1. We hypothesised that two chromatin remodellers with apparently opposing biochemical activities would antagonistically maintain enhancer structure. Loss of either should have opposite conseqeunces for gene expression, transcription factor binding, and response to signalling. 
@the_Node @SCICambridge 2. Using inducible degradation systems and careful temporal analysis, we proved that this is WRONG!
@the_Node @SCICambridge 3.Rather, Brg1 and Chd4 are both required for enhancer integrity, and both are required for an appropriate signalling response.
@the_Node @SCICambridge We (@BDH_Lab) are now re-defining the relationship between chromatin remodellers, transcription factors and signalling during lineage commitment in pluripotent cells.
#BSDBGenSoc2020
#BSDBGenSoc2020
