147/x
148/x
Wearing a mask can help mitigate the super spreading phenomena:
Wearing a mask can help mitigate the super spreading phenomena:
149/x
We should also be on the lookout for asymptomatic cases, as they can significantly contribute in adding to infections, should they go unchecked; We need more testing in general, as well as of asymptomatics:
We should also be on the lookout for asymptomatic cases, as they can significantly contribute in adding to infections, should they go unchecked; We need more testing in general, as well as of asymptomatics:
150/x
@carlzimmer on seeding of epidemics, this is important to understand, if we hope to gain control:
@carlzimmer on seeding of epidemics, this is important to understand, if we hope to gain control:
151a/x
@intelligencer catches the essence of dangers of reopening without sufficient test-trace-isolate-support infrastructure in place.
"In the absence of widespread, repeatable, & accurate testing, we’re left with a radically unfair choice. "
@intelligencer catches the essence of dangers of reopening without sufficient test-trace-isolate-support infrastructure in place.
"In the absence of widespread, repeatable, & accurate testing, we’re left with a radically unfair choice. "
152b/x
@intelligencer @JDavidsonNYC
continues:
"Instead of isolating the infected, we will isolate the old and infirm, as well as plenty of vigorous people with an assortment of risk factors."
@intelligencer @JDavidsonNYC
continues:
"Instead of isolating the infected, we will isolate the old and infirm, as well as plenty of vigorous people with an assortment of risk factors."
153/x
Maybe I'm going a bit off topic on previous from super seeding/spreading, but in order to control SSE's, or any aspect of this crises for that matter, I think that there will have to be holistic solution(s), so it would be counterproductive to strictly exclude by category.
Maybe I'm going a bit off topic on previous from super seeding/spreading, but in order to control SSE's, or any aspect of this crises for that matter, I think that there will have to be holistic solution(s), so it would be counterproductive to strictly exclude by category.
154/x
But enough digressing, maybe I will have to open another thread(s) on various interrelated subjects later on..
But enough digressing, maybe I will have to open another thread(s) on various interrelated subjects later on..
155/x
157/x
Masks to prevent 'normal' / super spreading events, naysayers debunked, by @trishgreenhalgh via @EricTopol
Masks to prevent 'normal' / super spreading events, naysayers debunked, by @trishgreenhalgh via @EricTopol
158/x
Masks have already been proven to work in South-Korea during SARS and MERS outbreaks:
Masks have already been proven to work in South-Korea during SARS and MERS outbreaks:
159/x
A thread [narrated in finnish} summarizing some studies of the benefits of masks in mitigating viral spreading,
collated by @HeikkiRay:
A thread [narrated in finnish} summarizing some studies of the benefits of masks in mitigating viral spreading,
collated by @HeikkiRay:
160/x
161/x
Mask use is correlated with fewer SARS-CoV-2 infections among HCW's:
Mask use is correlated with fewer SARS-CoV-2 infections among HCW's:
162/x
Suggestions of 🦠severity being Dose-Dependency related:
"A higher dose is clearly worse, though, and that may explain why some young health care workers have fallen victim even though the virus usually targets older people."
via @drannehuang:
Suggestions of 🦠severity being Dose-Dependency related:
"A higher dose is clearly worse, though, and that may explain why some young health care workers have fallen victim even though the virus usually targets older people."
via @drannehuang:
163/x
Superspreading event in a highschool in Jerusalem:
Superspreading event in a highschool in Jerusalem:
164/x
A good thread on super spreading by @thlbr, narrated in Finnish. (you can always use the twitter inbuilt translation, some articles in the thread are in English though)
A good thread on super spreading by @thlbr, narrated in Finnish. (you can always use the twitter inbuilt translation, some articles in the thread are in English though)
165/x
It seems the recent large protests are tallying up, possible SSE's suspected, via @BlockClubCHI:
It seems the recent large protests are tallying up, possible SSE's suspected, via @BlockClubCHI:
166/x
And article on the dispersion (K factor) and super spreading, by @guardian, via @BrianUkulele:
And article on the dispersion (K factor) and super spreading, by @guardian, via @BrianUkulele:
167/x
An article (in Dutch) written 24th April 2020 on super spreading and aerosols before the Netherland lockdown, by @mauricedehond :
An article (in Dutch) written 24th April 2020 on super spreading and aerosols before the Netherland lockdown, by @mauricedehond :
168/x
Worry-some footage from Kreutzberg, Berlin, 🇩🇪 from 31st May 2020, large crowds gathering, possible SSE's in the making ?
by @vincentbruckma, via @tweeterinshock:
Worry-some footage from Kreutzberg, Berlin, 🇩🇪 from 31st May 2020, large crowds gathering, possible SSE's in the making ?
by @vincentbruckma, via @tweeterinshock:
170/x
@adambanksdotcom counters the "low-risk-at-schools with low effective R"-argument with an eye on Super Spreading events, like the one in Israeli school recently:
@adambanksdotcom counters the "low-risk-at-schools with low effective R"-argument with an eye on Super Spreading events, like the one in Israeli school recently:
171/x
A different view, via @NeuroInfanti:
"The relatively large values of k implied that large cluster sizes, compatible with super-spreading, were unlikely."
A different view, via @NeuroInfanti:
"The relatively large values of k implied that large cluster sizes, compatible with super-spreading, were unlikely."
174/x
[in 🇩🇪 language] Corona Bulletin # 11: Why Perhaps More People Have Been Exposed to the Virus Than Thought, and How Superspreaders Drive the Pandemic: by @c_drosten, thematized in @ndr, via @laurentho77 & @theresluethi:
[in 🇩🇪 language] Corona Bulletin # 11: Why Perhaps More People Have Been Exposed to the Virus Than Thought, and How Superspreaders Drive the Pandemic: by @c_drosten, thematized in @ndr, via @laurentho77 & @theresluethi:
176/x
Article on the 10/80 theory/principle on SSE's. Published in @bopinion written by @foxjust, via @Anshul__K: [also refer to post 9/x in this thread, the pareto-principle by @EricTopol]:
Article on the 10/80 theory/principle on SSE's. Published in @bopinion written by @foxjust, via @Anshul__K: [also refer to post 9/x in this thread, the pareto-principle by @EricTopol]:
177/x
"When 80% of people wear a mask, the spread of the corona stops." by @ConversationUS via @ValliTimo
"When 80% of people wear a mask, the spread of the corona stops." by @ConversationUS via @ValliTimo
179/x
"What does San Francisco’s new 9-meter rule mean? In short: keep you mask with you at all times."
by @tomasaragon in @sfchronicle, via @senjalarsen:
"What does San Francisco’s new 9-meter rule mean? In short: keep you mask with you at all times."
by @tomasaragon in @sfchronicle, via @senjalarsen:
180/x
More spotlight is now shifting into the role of SSE's, as @mvankerkhove / @WHO warns about "..Super Spreading Events, which take place in closed facilities or in situations where you have very close contact with people",
via @HeikkiRay & @QuickTake:
More spotlight is now shifting into the role of SSE's, as @mvankerkhove / @WHO warns about "..Super Spreading Events, which take place in closed facilities or in situations where you have very close contact with people",
via @HeikkiRay & @QuickTake:
181/x
A classic SSE case from China highlights the perils of riding a bus without mask; infectious person did not wear one, and all 13 unmasked passengers became infected.
None of the passengers wearing a mask were infected.
by @newscomauHQ via @jmrockh
A classic SSE case from China highlights the perils of riding a bus without mask; infectious person did not wear one, and all 13 unmasked passengers became infected.
None of the passengers wearing a mask were infected.
by @newscomauHQ via @jmrockh
182/x
@bencowling88 and @DillonCAdam on growing evidence on the significance of Super Spreading Events, via @kakape:
@bencowling88 and @DillonCAdam on growing evidence on the significance of Super Spreading Events, via @kakape:
185/x
'Here's the 2005 @nature article by @jlloydsmith
et. al. that showed that a tendency toward superspreading makes "disease extinction more likely and outbreaks rarer but more explosive."', via @foxjust:
'Here's the 2005 @nature article by @jlloydsmith
et. al. that showed that a tendency toward superspreading makes "disease extinction more likely and outbreaks rarer but more explosive."', via @foxjust:
188/x
Re-emphasis on previous entry #182/x on this thread on Super Spreading in @nytopinion, by @DillonCAdam @bencowling88 via @EricTopol:
Re-emphasis on previous entry #182/x on this thread on Super Spreading in @nytopinion, by @DillonCAdam @bencowling88 via @EricTopol:
189/x
"What prevents #COVID19 spread?
An exceptional systematic analysis of 172 global studies in ~26,000 people (not randomized trials)"
thelancet.com/journals/lance…
@TheLancet via @EricTopol
"What prevents #COVID19 spread?
An exceptional systematic analysis of 172 global studies in ~26,000 people (not randomized trials)"
thelancet.com/journals/lance…
@TheLancet via @EricTopol
190/x
Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event.
via @GidMK
Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event.
via @GidMK
191/x
Testing Asymptomatics widely could prevent normal and super spreading events, as:
"Asymptomatics persons seem to account for approximately 40%-45% of #SARSCoV2 infections"
via @DrEricDing:
Testing Asymptomatics widely could prevent normal and super spreading events, as:
"Asymptomatics persons seem to account for approximately 40%-45% of #SARSCoV2 infections"
via @DrEricDing:
194/x
New Super Spreading event in South-Korea's table tennis club. Proper tracing allowed them to track it to it's origin.
via @DrEricDing:
New Super Spreading event in South-Korea's table tennis club. Proper tracing allowed them to track it to it's origin.
via @DrEricDing:
195/x
"70% of people infected with the coronavirus did not pass it to anyone, preliminary research shows. Superspreading events account for most transmission." businessinsider.com/super-spreader… via @k_abatayo & @businessinsider:
"70% of people infected with the coronavirus did not pass it to anyone, preliminary research shows. Superspreading events account for most transmission." businessinsider.com/super-spreader… via @k_abatayo & @businessinsider:
196/x
Viral Shedding and COVID-19 Superspreading Events
A Review by the Fellows Behind the Literature Updates
medscape.com/viewarticle/93… via @Golfer59Martin & @Medscape:
Viral Shedding and COVID-19 Superspreading Events
A Review by the Fellows Behind the Literature Updates
medscape.com/viewarticle/93… via @Golfer59Martin & @Medscape:
198/x
„Es war das ideale Super-Spreading-Event“ tagesspiegel.de/politik/anti-r…
via @NLituanie, @Tagesspiegel:
„Es war das ideale Super-Spreading-Event“ tagesspiegel.de/politik/anti-r…
via @NLituanie, @Tagesspiegel:
199/x
"Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, Feb. & Mar. 2020" - now peer-reviewed & out in
@Eurosurveillanc, via @AlexDilthey eurosurveillance.org/content/10.280…
"Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, Feb. & Mar. 2020" - now peer-reviewed & out in
@Eurosurveillanc, via @AlexDilthey eurosurveillance.org/content/10.280…
200/x
Outdoor events can carry 2.5X increase in the rate of infection due to Super Spreading/Seeding events, via @ScottGottliebMD, @medrxivpreprint, @FaceTheNation:
Outdoor events can carry 2.5X increase in the rate of infection due to Super Spreading/Seeding events, via @ScottGottliebMD, @medrxivpreprint, @FaceTheNation:
201/x
The police, going about mostly unmasked, in the US, cause concern among citizens, as they might be contributing to the possible Super Spreading events among US protests due to not wearing a mask. via @cfrln:
The police, going about mostly unmasked, in the US, cause concern among citizens, as they might be contributing to the possible Super Spreading events among US protests due to not wearing a mask. via @cfrln:
202/x
A study comparing different languages spoken at different volumes and differences in produced particle emissions.
via @shayla__love, @VICE:
A study comparing different languages spoken at different volumes and differences in produced particle emissions.
via @shayla__love, @VICE:
203/x
Ghana issues 5million ID and voter registration's in 4000 locations, reminding to keep an eye out for possible SSE's, via @CRC4D:
Ghana issues 5million ID and voter registration's in 4000 locations, reminding to keep an eye out for possible SSE's, via @CRC4D:
204/x
Poblacht na hÉireann's hospitality industry faces similar challenges as do others with balancing between safety and opening of society. via @ireland, @IrishTimes:
Poblacht na hÉireann's hospitality industry faces similar challenges as do others with balancing between safety and opening of society. via @ireland, @IrishTimes:
205/x
Contaminated surfaces gain some limelight in regards to SSE's, from Peter Sandman via @DrTomFrieden, @bencowling88:
Contaminated surfaces gain some limelight in regards to SSE's, from Peter Sandman via @DrTomFrieden, @bencowling88:
207/x
@ShellyMBoulder on Duration and Ventilation being a factor in the amount of infection risk in Super Spreading events:
@ShellyMBoulder on Duration and Ventilation being a factor in the amount of infection risk in Super Spreading events:
209/x
A good thread evaluating risk factors and mitigations for Super Spreading Events, by @JeremyKonyndyk:
A good thread evaluating risk factors and mitigations for Super Spreading Events, by @JeremyKonyndyk:
210/x
In 🇳🇱 the citizens and Muslim community is active in trying to mitigate possible SSE's, among helping others. This kind of whole community participation is needed around the globe. A great example from 🇳🇱 @Compier_MD:
In 🇳🇱 the citizens and Muslim community is active in trying to mitigate possible SSE's, among helping others. This kind of whole community participation is needed around the globe. A great example from 🇳🇱 @Compier_MD:
213/x
The Israeli study tracked the virus’s origin to the person who brought it with them from overseas.
The study showed that over 80 percent of them were infected by 1 to 10 percent of foreign superspreaders.
via @mikenov, @worldisraelnews:
The Israeli study tracked the virus’s origin to the person who brought it with them from overseas.
The study showed that over 80 percent of them were infected by 1 to 10 percent of foreign superspreaders.
via @mikenov, @worldisraelnews:
214/x
215/x
"Asymptomatic carriers of #SARSCoV2 rarely give other people #COVID19 - Wrong."
via @Laurie_Garrett:
"Asymptomatic carriers of #SARSCoV2 rarely give other people #COVID19 - Wrong."
via @Laurie_Garrett:
216/x
chvnradio.com/christian-news…
"🇨🇦Ontario churches set to reopen at 30% capacity, province-wide, regardless of confirmed COVID cases."
"Superspreader events linked to houses of worship have been notable in the history of COVID19."
via @chvn951, @DFisman:
chvnradio.com/christian-news…
"🇨🇦Ontario churches set to reopen at 30% capacity, province-wide, regardless of confirmed COVID cases."
"Superspreader events linked to houses of worship have been notable in the history of COVID19."
via @chvn951, @DFisman:
217/x
⚠️ In 🇮🇳, Daesh 📰 promotes superspreading;
asking Muslims to become COVID-19 carriers and
spread 🦠amongst disbelievers.
⚠️Experts call it a sinister plot of information warfare that could lead to a biological warfare.
via @arunpudur, @TimesNow:
⚠️ In 🇮🇳, Daesh 📰 promotes superspreading;
asking Muslims to become COVID-19 carriers and
spread 🦠amongst disbelievers.
⚠️Experts call it a sinister plot of information warfare that could lead to a biological warfare.
via @arunpudur, @TimesNow:
219/x
New preprint on the successful suppression of 1st wave of #COVID19 in Hong Kong from @bencowling88 and @gmleunghku:
"14 day quarantine of arrivals..since early Feb reduced onwards transmission by 95%."
New preprint on the successful suppression of 1st wave of #COVID19 in Hong Kong from @bencowling88 and @gmleunghku:
"14 day quarantine of arrivals..since early Feb reduced onwards transmission by 95%."
220/x
"In our other preprint on superspreading we reported just one example of a 'failure' of quarantine – a close contact was quarantined without symptoms but had already passed on infection to his wife. researchsquare.com/article/rs-295…"
via @bencowling88:
"In our other preprint on superspreading we reported just one example of a 'failure' of quarantine – a close contact was quarantined without symptoms but had already passed on infection to his wife. researchsquare.com/article/rs-295…"
via @bencowling88:
221/x
International air-travel should take a cue from Hong Kong in mitigating spreading:
International air-travel should take a cue from Hong Kong in mitigating spreading:
222/x
A thread by @DKThomp:
"3 CDC studies; a restaurant, a call center, and an choir practice, concluded that talking, laughing, singing in close quarters, in unventilated interiors, for many hours, is the perfect storm for a COVID super-spreader event.
A thread by @DKThomp:
"3 CDC studies; a restaurant, a call center, and an choir practice, concluded that talking, laughing, singing in close quarters, in unventilated interiors, for many hours, is the perfect storm for a COVID super-spreader event.
223/x
A good thread analysing several incidents of transmission clusters and attack rates from @mugecevik:
A good thread analysing several incidents of transmission clusters and attack rates from @mugecevik:
224/x
A recent Coal mine superspreading event in 🇵🇱.
The whole thread is solid and well worth the read as it includes many theories, studies and events regarding Super Spreading/Seeding Events, by @bopanc:
A recent Coal mine superspreading event in 🇵🇱.
The whole thread is solid and well worth the read as it includes many theories, studies and events regarding Super Spreading/Seeding Events, by @bopanc:
225/x
The Science of SuperSpreaders
A fraction of infected people trigger the bulk of new cases.
Scientists agree that talking can spread virus-containing respiratory particles, and some people emit more than others.
by @RobertRoyBritt in @elemental:
The Science of SuperSpreaders
A fraction of infected people trigger the bulk of new cases.
Scientists agree that talking can spread virus-containing respiratory particles, and some people emit more than others.
by @RobertRoyBritt in @elemental:
226/x
The importance of mask wearing to curb the normal and super spreading events especially in light of the asymptomatics spreading the virus, from @DrEricDing:
The importance of mask wearing to curb the normal and super spreading events especially in light of the asymptomatics spreading the virus, from @DrEricDing:
227/x
A #COVID19 superspreader unknowingly infected 52 people with the new coronavirus at a choir practice in
🇺🇸 Mount Vernon, Washington, early March, leading to the deaths of two people, a CDC report finds. via @rcolintait:
A #COVID19 superspreader unknowingly infected 52 people with the new coronavirus at a choir practice in
🇺🇸 Mount Vernon, Washington, early March, leading to the deaths of two people, a CDC report finds. via @rcolintait:
229/x
Testing Asymptomatic's and wearing masks are important in controlling #Covid19 spread.
Article in @PostOpinions by @EricTopol & @danieloran, via @DrLeanaWen:
Testing Asymptomatic's and wearing masks are important in controlling #Covid19 spread.
Article in @PostOpinions by @EricTopol & @danieloran, via @DrLeanaWen:
230/x
"New and *powerful* new support for the efficacy of masks
—3-region analysis (NYC, Wuhan, Italy)
—Synthetic controls, Germany"
via @EricTopol:
"New and *powerful* new support for the efficacy of masks
—3-region analysis (NYC, Wuhan, Italy)
—Synthetic controls, Germany"
via @EricTopol:
232/x
An example on the importance of testing asymptomatics, via @bergman_paula:
"Nearly 100 test-positive (so far asymptomatic) participants in asparagus harvesting on a Bayer farm. The source of the infection is unknown, but the outbreak is limited."
An example on the importance of testing asymptomatics, via @bergman_paula:
"Nearly 100 test-positive (so far asymptomatic) participants in asparagus harvesting on a Bayer farm. The source of the infection is unknown, but the outbreak is limited."
233/x
Movement restrictions, not herd-immunity is what has most likely slowed down epidemic in Europe.
via @nataliexdean:
Movement restrictions, not herd-immunity is what has most likely slowed down epidemic in Europe.
via @nataliexdean:
234/x
Super Spreading event in concert in Finland on Women's Day 8th March 2020 infected more than 100:
via @HeikkiRay:
Super Spreading event in concert in Finland on Women's Day 8th March 2020 infected more than 100:
via @HeikkiRay:
235/x
"airborne transmission dominant route"
pnas.org/content/early/… "...face covering represents the determinant in shaping the pandemic trends...significantly reduced the number of infections...social distancing [is] insufficient..."
via @linseymarr:
"airborne transmission dominant route"
pnas.org/content/early/… "...face covering represents the determinant in shaping the pandemic trends...significantly reduced the number of infections...social distancing [is] insufficient..."
via @linseymarr:
236/x
"Excellent work by NBACC showing that aerosolized virus decays rapidly in sunlight: 90% gone in 6 min in summer. Some of these wavelengths also go through windows, too." academic.oup.com/jid/advance-ar…
via @linseymarr:
"Excellent work by NBACC showing that aerosolized virus decays rapidly in sunlight: 90% gone in 6 min in summer. Some of these wavelengths also go through windows, too." academic.oup.com/jid/advance-ar…
via @linseymarr:
237/x
"Identifying airborne transmission as the dominant route for spread of COVID-19
Analysis by Nobel Laureate Mario Molina uses the sequential start of soc-dist, stay-at-home, & mask mandates to show only face masks worked -> airborne transmission"
"Identifying airborne transmission as the dominant route for spread of COVID-19
Analysis by Nobel Laureate Mario Molina uses the sequential start of soc-dist, stay-at-home, & mask mandates to show only face masks worked -> airborne transmission"
238/x
2nd take ?:
"I got a little too excited at first about this paper about airborne transmission and masks. pnas.org/content/early/… See the thread for more /1! "
via @linseymarr
2nd take ?:
"I got a little too excited at first about this paper about airborne transmission and masks. pnas.org/content/early/… See the thread for more /1! "
via @linseymarr
240/x
🇫🇮 Finland not included:
"Zero out.
The way to beat #COVID19.
For cases, Iceland, New Zealand and Taiwan"
a thread from @EricTopol:
🇫🇮 Finland not included:
"Zero out.
The way to beat #COVID19.
For cases, Iceland, New Zealand and Taiwan"
a thread from @EricTopol:
241/x
"The paper also calls out @WHO and @cdc "
[ what about STM and THL ? ]
"for “largely ignoring” the importance of airborne transmission. And also blames the lack of face #mask as key factor for poor trends in many countries."
via @DrEricDing:
"The paper also calls out @WHO and @cdc "
[ what about STM and THL ? ]
"for “largely ignoring” the importance of airborne transmission. And also blames the lack of face #mask as key factor for poor trends in many countries."
via @DrEricDing:
243/x
"For some reason, many countries test much more than 🇫🇮. That reason seems to be that massive testing is the only way to get the restrictions removed, and also to keep them removed, and get GDP back on track. 🇳🇿 lifted all restrictions on 8 June. "
"For some reason, many countries test much more than 🇫🇮. That reason seems to be that massive testing is the only way to get the restrictions removed, and also to keep them removed, and get GDP back on track. 🇳🇿 lifted all restrictions on 8 June. "
245/x
"In 🇫🇮, more testing capacity has been acquired, even though the number of new infections is declining. Maybe for massive testing. We now have 6 times more capacity than what is currently needed.
I bet more will be acquired again. "
from @jukka235:
"In 🇫🇮, more testing capacity has been acquired, even though the number of new infections is declining. Maybe for massive testing. We now have 6 times more capacity than what is currently needed.
I bet more will be acquired again. "
from @jukka235:
246/x
"Reason being, that these countries, which have already overcome epidemic, are now removing restrictions, getting people back to work & GDP on track is testing avg. 30x as much as 🇫🇮 where ppl are sitting home and Government is taking on more debt.
"Reason being, that these countries, which have already overcome epidemic, are now removing restrictions, getting people back to work & GDP on track is testing avg. 30x as much as 🇫🇮 where ppl are sitting home and Government is taking on more debt.
247/x
"Countries at tail end of the list will not be able to open up their economies, and will lose out in competition to those that can. Of course, you can try, as was done in USA and get slapped. The US Fed lowered the outlook --recession is coming."
"Countries at tail end of the list will not be able to open up their economies, and will lose out in competition to those that can. Of course, you can try, as was done in USA and get slapped. The US Fed lowered the outlook --recession is coming."
248/x
"Top 10 of #herdimmunity countries; With this strategy, (1) lot of people will die, (2) government will lose support when people become disillusioned, and (3) restrictions will not be lifted and they will have to watch by as other countries start."
"Top 10 of #herdimmunity countries; With this strategy, (1) lot of people will die, (2) government will lose support when people become disillusioned, and (3) restrictions will not be lifted and they will have to watch by as other countries start."
249/x
"The 🇬🇧 UK started with a #herdimmunity strategy, as did 🇫🇮 Finland.
Now they have 41,000 dead[in 🇬🇧], and the citizens no longer have any delusions. "
from @jukka235:
"The 🇬🇧 UK started with a #herdimmunity strategy, as did 🇫🇮 Finland.
Now they have 41,000 dead[in 🇬🇧], and the citizens no longer have any delusions. "
from @jukka235:
250/x
"🇬🇧, which among 🇸🇪 has had the purest form #herdimmunity strategy in 🇪🇺 got the result of an economic disaster.
Restrictions can not be lifted for a long time.
Johnson's position is precarious.
The own dogs are about to bite. "
from @jukka235:
"🇬🇧, which among 🇸🇪 has had the purest form #herdimmunity strategy in 🇪🇺 got the result of an economic disaster.
Restrictions can not be lifted for a long time.
Johnson's position is precarious.
The own dogs are about to bite. "
from @jukka235:
251/x
"In 🇸🇪 Sweden, too, the situation is becoming increasingly difficult for the government.
Swedes are being isolated as other countries remove restrictions. "
from @jukka235:
"In 🇸🇪 Sweden, too, the situation is becoming increasingly difficult for the government.
Swedes are being isolated as other countries remove restrictions. "
from @jukka235:
252/x
"A lot of states in the 🇺🇸 USA, have a combination where:
(1) restrictions are removed and
(2) no tests are performed.
Now there are so many new infections that..."
from @jukka235:
"A lot of states in the 🇺🇸 USA, have a combination where:
(1) restrictions are removed and
(2) no tests are performed.
Now there are so many new infections that..."
from @jukka235:
254/x
"A lot of states perform even less testing than 🇸🇪 Sweden.
Or even less than 🇮🇷 Iran.
Lifting restrictions combined with inadequate testing is a mortal combination. "
from @jukka235:
"A lot of states perform even less testing than 🇸🇪 Sweden.
Or even less than 🇮🇷 Iran.
Lifting restrictions combined with inadequate testing is a mortal combination. "
from @jukka235:
255/x
"In Arizona which performs least testing in 🇺🇸, restrictions were lifted last month.
Epidemic is now starting to grow pretty badly, and people are dying.
New lockdown is on it's way with no hope of getting the economy going."
from @jukka235:
"In Arizona which performs least testing in 🇺🇸, restrictions were lifted last month.
Epidemic is now starting to grow pretty badly, and people are dying.
New lockdown is on it's way with no hope of getting the economy going."
from @jukka235:
256/x
"In other words; testing is an investment in getting the economy up and running.
Without 50,000 🇫🇮 Finns ⚰️dying🪦."
from @jukka235:
"In other words; testing is an investment in getting the economy up and running.
Without 50,000 🇫🇮 Finns ⚰️dying🪦."
from @jukka235:
257/x
⚠️"Younger adults were the main source of 61 different outbreak clusters in Japan.
In this study (in a CDC journal), contact tracing isolated the primary source of 61 epidemic clusters to be mostly younger adults!"
via @DrEricDing:
⚠️"Younger adults were the main source of 61 different outbreak clusters in Japan.
In this study (in a CDC journal), contact tracing isolated the primary source of 61 epidemic clusters to be mostly younger adults!"
via @DrEricDing:
258/x
“We also identified 22 probable primary case-patients for the clusters; most were 20–39 y/o and pre- or asymptomatic at virus transmission.”
And of hotspots, 20-39 y/o who had no symptoms were the main primary SOURCE of these hotspot clusters!!!"
“We also identified 22 probable primary case-patients for the clusters; most were 20–39 y/o and pre- or asymptomatic at virus transmission.”
And of hotspots, 20-39 y/o who had no symptoms were the main primary SOURCE of these hotspot clusters!!!"
259/x
“For 16 clusters, we determined date of transmission and found 41% of probable primary case-patients were pre- or asymptomatic at time of transmission; only 1 had cough at time of transm...”
MANY NO SYMPTOMS FOR INITIAL OUTBREAK EVENT! Masks now!
“For 16 clusters, we determined date of transmission and found 41% of probable primary case-patients were pre- or asymptomatic at time of transmission; only 1 had cough at time of transm...”
MANY NO SYMPTOMS FOR INITIAL OUTBREAK EVENT! Masks now!
260/x
"Now months later, we have indeed confirmed from 🇯🇵 contact tracing of clusters, that most outbreak clusters all started from primary cases who were YOUNG, many NO SYMPTOMS, and in all hotspots public health officials have been warning about.."
"Now months later, we have indeed confirmed from 🇯🇵 contact tracing of clusters, that most outbreak clusters all started from primary cases who were YOUNG, many NO SYMPTOMS, and in all hotspots public health officials have been warning about.."
261/x
An interesting thread by @mugecevik pondering the role, definition and transmission dynamics of asymptomatics and presymptomatics among other things, while also touching the super seeding/spreading phenomena.
Well worth the read:
from @mugecevik:
An interesting thread by @mugecevik pondering the role, definition and transmission dynamics of asymptomatics and presymptomatics among other things, while also touching the super seeding/spreading phenomena.
Well worth the read:
from @mugecevik:
263/x
"Report Suggests Some “Mildly Symptomatic” Covid-19 Patients Endure Serious Long-Term Effects"
Via @_atanas_:
"Report Suggests Some “Mildly Symptomatic” Covid-19 Patients Endure Serious Long-Term Effects"
Via @_atanas_:
264/x
"#Covid19 is not a mild cold. It is debilitating. Survivors continue to suffer: Some have lungs that will never breathe easy, others foggy brains and paralyzed limbs, failing kidneys, or hearts that swell and veins that burst."
From @WmHaseltine:
"#Covid19 is not a mild cold. It is debilitating. Survivors continue to suffer: Some have lungs that will never breathe easy, others foggy brains and paralyzed limbs, failing kidneys, or hearts that swell and veins that burst."
From @WmHaseltine:
265/x
"Signs are pointing to Beijing tightening COVID-19 measures again because of what appears to be a cluster infection from Xinfadi market."
Via @Rover829, @catecadell:
"Signs are pointing to Beijing tightening COVID-19 measures again because of what appears to be a cluster infection from Xinfadi market."
Via @Rover829, @catecadell:
266/x
⚠️"Beijing district now in full “wartime emergency” over new outbreak...Xinfadi market where it started is not some dinky Wuhan wet market - it’s a mega market scale on order of 1/3 of Central Park!
☣️Epidemic potential huge"
Via @DrEricDing:
⚠️"Beijing district now in full “wartime emergency” over new outbreak...Xinfadi market where it started is not some dinky Wuhan wet market - it’s a mega market scale on order of 1/3 of Central Park!
☣️Epidemic potential huge"
Via @DrEricDing:
268/x
🇳🇱 "This is why de Volkskrant refutes all criticism of the government's approach to COVID-19
Pieter Klok believes that government, science and journalism should speak with one voice"
from @ContainmentNu:
🇳🇱 "This is why de Volkskrant refutes all criticism of the government's approach to COVID-19
Pieter Klok believes that government, science and journalism should speak with one voice"
from @ContainmentNu:
269/x
270a/x
Some background: #Remdesivir interferes w/ cellular machinery that allows viruses to replicate inside human host.
Some background: #Remdesivir interferes w/ cellular machinery that allows viruses to replicate inside human host.
270b/x
It is a pro-drug which must be metabolized & undergo sequence of 5 bioactivation steps before becoming GS-441524 triphosphate, active compound impeding viral replication.
via @statnews
It is a pro-drug which must be metabolized & undergo sequence of 5 bioactivation steps before becoming GS-441524 triphosphate, active compound impeding viral replication.
via @statnews
271/x
Preliminary evidence indicates famotidine might improve COVID-19 symptoms
Publish date: June 9, 2020.
By Amy Karon via @HRafhumcar:
Preliminary evidence indicates famotidine might improve COVID-19 symptoms
Publish date: June 9, 2020.
By Amy Karon via @HRafhumcar:
272/x
"Students in S’pore to get hand sanitiser, with preschool and primary school kids also given face shields "
via @TODAYonline:
"Students in S’pore to get hand sanitiser, with preschool and primary school kids also given face shields "
via @TODAYonline:
274/x
"Can this whole thing be stopped if everyone wore a mask for a month?"
from @ScottGottliebMD, @DrSidMukherjee,
@PSampathkumarMD, @ASlavitt, @Rfonsi1, @choo_ek
via @VincentRK:
"Can this whole thing be stopped if everyone wore a mask for a month?"
from @ScottGottliebMD, @DrSidMukherjee,
@PSampathkumarMD, @ASlavitt, @Rfonsi1, @choo_ek
via @VincentRK:
275/x
"The Masks Masquerade - Incompetence and Errors in Reasoning Around Face Covering"
". a reduction of viral load by 75% for a short exposure could reduce the probability of infection by 95% or more!"
Article from @nntaleb via @HeikkiRay:
"The Masks Masquerade - Incompetence and Errors in Reasoning Around Face Covering"
". a reduction of viral load by 75% for a short exposure could reduce the probability of infection by 95% or more!"
Article from @nntaleb via @HeikkiRay:
276/x
Mandatory Mask use in a municipality in Mexico has reduced cases to almost non existent levels vs. municipalities which don't require it:
via @ExplicoLo:
Mandatory Mask use in a municipality in Mexico has reduced cases to almost non existent levels vs. municipalities which don't require it:
via @ExplicoLo:
277/x
⚠️Study: 100% face mask😷 use could crush second, third #COVID19 wave:
An article by @Mike_at_SFGate in @SFGate, via @Benioff:
⚠️Study: 100% face mask😷 use could crush second, third #COVID19 wave:
An article by @Mike_at_SFGate in @SFGate, via @Benioff:
278/x
Study: "Appropriate PPE gives HCWs a high level of protection against covid-19. Despite high risk of exposure, study participants were appropriately protected and not infected"
According to 🇫🇮 THL & STM, PPE only helps HCWs, not ordinary citizens.
Study: "Appropriate PPE gives HCWs a high level of protection against covid-19. Despite high risk of exposure, study participants were appropriately protected and not infected"
According to 🇫🇮 THL & STM, PPE only helps HCWs, not ordinary citizens.
279/x
"This study compared *self-collected* LOWER nose swabs (way less uncomfortable) to throat swabs.
No difference in viral detection.
Accurate, convenient & less PPE use."
via @BogochIsaac, a study in @JAMANetworkOpen:
"This study compared *self-collected* LOWER nose swabs (way less uncomfortable) to throat swabs.
No difference in viral detection.
Accurate, convenient & less PPE use."
via @BogochIsaac, a study in @JAMANetworkOpen:
280/x
"Those horrified by 🇳🇿 NZ’s total lockdown can now testify the results:
Freedom to live without fear until vaccine arrives.
Services & business booming.
People moving as before.
And the radar stays on all the time."
via @jakivisto, @DrEricDing:
"Those horrified by 🇳🇿 NZ’s total lockdown can now testify the results:
Freedom to live without fear until vaccine arrives.
Services & business booming.
People moving as before.
And the radar stays on all the time."
via @jakivisto, @DrEricDing:
281/x
"This must be said clearly: Masks are incredibly important. Anyone who is taking risks because of external conditions or specific needs should wear a mask. Let others know and model this for them. Thanks @zeynep @nntaleb @hjluks"
via @yaneerbaryam:
"This must be said clearly: Masks are incredibly important. Anyone who is taking risks because of external conditions or specific needs should wear a mask. Let others know and model this for them. Thanks @zeynep @nntaleb @hjluks"
via @yaneerbaryam:
282/x
"Another new study on😷wearing: but this time assuming R0 of 2.2 or 4, effectiveness against trans, & pop% wearing it. Good news is it works. Bad news: it needs high 95% effectiveness and also high 75% or more😷wearing compliance to get under R<1."
"Another new study on😷wearing: but this time assuming R0 of 2.2 or 4, effectiveness against trans, & pop% wearing it. Good news is it works. Bad news: it needs high 95% effectiveness and also high 75% or more😷wearing compliance to get under R<1."
283/x
"New Surgeon General 😷facemask message:
"If more wear them, we'll have MORE freedom to go out"
via @DrEricDing:
"New Surgeon General 😷facemask message:
"If more wear them, we'll have MORE freedom to go out"
via @DrEricDing:
284/x
We asked 6000 epidemiologists a series of unanswerable questions based on insufficient information.
5200 ignored us, 500 answered anyway, and only 300 took the time to write and tell us to f*ck off.
via @DrEricDing, @CT_Bergstrom:
We asked 6000 epidemiologists a series of unanswerable questions based on insufficient information.
5200 ignored us, 500 answered anyway, and only 300 took the time to write and tell us to f*ck off.
via @DrEricDing, @CT_Bergstrom:
285/x
@ASlavitt:
"NEW: Study from Japan shows spread originating from younger people & 40% pre- or asymptomatic.
We have been waiting for data to ID most likely sources & need more. Thanks to more. Thanks to @DrEricDing.
Read every bit of his thread."
@ASlavitt:
"NEW: Study from Japan shows spread originating from younger people & 40% pre- or asymptomatic.
We have been waiting for data to ID most likely sources & need more. Thanks to more. Thanks to @DrEricDing.
Read every bit of his thread."
286/x
✨@DrDenaGrayson puts the so called experts, epidemiologists, and other people who for some reason have unscientifically downplayed both the asymptomatic spreading and the assumption that young people do not transmit the virus to shame:
✨@DrDenaGrayson puts the so called experts, epidemiologists, and other people who for some reason have unscientifically downplayed both the asymptomatic spreading and the assumption that young people do not transmit the virus to shame:
287/x
#covid19 Clusters, Aerosol Transmission, and super spreading amongst young people.
via @JyrkiLoima @DrEricDing:
#covid19 Clusters, Aerosol Transmission, and super spreading amongst young people.
via @JyrkiLoima @DrEricDing:
288/x
"A very Swedish sort of failure
A flawed policy on Covid-19 was driven by the country’s exceptionalism"
via @FT:
"A very Swedish sort of failure
A flawed policy on Covid-19 was driven by the country’s exceptionalism"
via @FT:
289/x
291/x
@WHO is directing more much needed focus on #clustering and #SuperSpreading Events, as Japanese paper tweeted by @kakape's on the phenomenon is mentioned by @DrMikeRyan:
@WHO is directing more much needed focus on #clustering and #SuperSpreading Events, as Japanese paper tweeted by @kakape's on the phenomenon is mentioned by @DrMikeRyan:
293/x
@AbraarKaran appears on @NBCNews to talk about Super Spreading Events and transmission dynamics:
@AbraarKaran appears on @NBCNews to talk about Super Spreading Events and transmission dynamics:
294/x
The lies of "false sense of security from mask use" that the 🇸🇪FHM, 🇳🇱 RIVM, 🇫🇮 THL (Mika Salminen especially), STM (Kirsi Varhila especially) & the rest of the Government apread, DEBUNKED, by real scientists:
From @AbraarKaran & @zeynep:
The lies of "false sense of security from mask use" that the 🇸🇪FHM, 🇳🇱 RIVM, 🇫🇮 THL (Mika Salminen especially), STM (Kirsi Varhila especially) & the rest of the Government apread, DEBUNKED, by real scientists:
From @AbraarKaran & @zeynep:
296/x
@WIRED is waking up the 'wired folks' as it puts out a nice piece about Super Spreading events, by @mattsreynolds1:
@WIRED is waking up the 'wired folks' as it puts out a nice piece about Super Spreading events, by @mattsreynolds1:
298/x
"Determining...asymptomatic rather than "unusually symptomatic" can be tricky.
This explains...why pandemic has been so hard to control, and why interventions that work whether or not a person has symptoms are the effective ones."
from @BillHanage:
"Determining...asymptomatic rather than "unusually symptomatic" can be tricky.
This explains...why pandemic has been so hard to control, and why interventions that work whether or not a person has symptoms are the effective ones."
from @BillHanage:
299/x
@DrZoeHyde summarizes the importance of testing children, even if asymptomatic:
"both child-to-child and child-to-adult transmission has occurred; cases in children are being missed."
@DrZoeHyde summarizes the importance of testing children, even if asymptomatic:
"both child-to-child and child-to-adult transmission has occurred; cases in children are being missed."
300/x
"Suppression of #COVID_19 outbreak in the municipality of Vo, Italy bit.ly/2YBGGxk Looks like many concepts need to be revised and the #lockdown was simply not effective #coronavirus #pandemic bit.ly/2VqUYjY"
301/x
Border controls, testing, quarantine and protocols urgently needed as travelers from mass infected #Herdimmunity countries are destroying the good progress that Containment countries have made. via @COSseaton:
Border controls, testing, quarantine and protocols urgently needed as travelers from mass infected #Herdimmunity countries are destroying the good progress that Containment countries have made. via @COSseaton:
302/x
"There are numerous combinations of symptoms in #COVID19 that do not include fever. Screening for fever alone may miss many cases."
via @CMichaelGibson, from @MackayIM:
303/x
"UK RECOVERY trial shapes up to be the most impactful trial so far by ruling out controversial #Hydroxychloroquine and instead demonstrating mortality benefit for a cheap steroid #dexamethasone "
via @AndyBiotech, @zeynep:
304/x
"Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID-19"
via @JPosthumadeBoer, @MarcBonten:
306/x
"The sicker you are, the better it works"
#Dexamethasone reduced the mortality in #covid19 patients in a large British study, but the results have not been published yet.
via @JPosthumadeBoer from @MarcBonten
in @nrcwetenschap:
306/b
"In patients who needed to be on a ventilator, dexamethasone reduced the death rate by 35%.
In those who needed oxygen but were not ventilated, the death rate was reduced 20%"
statnews.com/2020/06/16/maj… via @MackayIM, @statnews
307/x
"We haven’t had a pandemic for 100 years. And data science, at least in its modern form, is an area that is still quite young.."
"We need to act now to begin developing a national, and ideally, global, network of data science rapid response teams. "
308/x
"Dexamethasone was tested in #COVID19 both given by mouth and through IV injection. FDA’s database shows the IV form is in shortage from some makers due to demand increase for the drug."
via @AndyBiotech, @megtirrell
"Dexamethasone was tested in #COVID19 both given by mouth and through IV injection. FDA’s database shows the IV form is in shortage from some makers due to demand increase for the drug."
via @AndyBiotech, @megtirrell
311/x
"How superspreading is fueling the pandemic — and how we can stop it"
By @KHCourage via @MinnaVakeva:
