Prof Chris P Gale Profile picture
Sep 1, 2020 30 tweets 12 min read Read on X
‘Although proportionately scarce, exercise may paradoxically trigger sudden cardiac arrest in individuals with #cardiovascular disease (CVD), particularly those who were previously sedentary or have advanced CVD.’
‘In parallel with the drive to promote #exercise in all individuals, physicians will be confronted with an increasing number of enquiries from individuals with established risk factors for coronary artery disease or established CVD about participation in exercise‘
‘Such consultations need to strike a balance between the multiple benefits of #exercise, the small risk of sudden death, and the patient’s goals for cardiorespiratory fitness & ongoing participation in relatively strenuous exercise following a #cardiovascular diagnosis.’
2020 ESC Guidelines on sports cardiology and #exercise in patients with #cardiovascular disease: #ESCCongress academic.oup.com/eurheartj/adva…
‘Moderate physical activity should be promoted in all individuals with #cardiovascular disease. Appropriate risk stratification & optimal therapy are essential for providing #exercise prescription for more vigorous activity.’
‘Individuals should be involved in the decision making process & a record of the discussion & #exercise plan should be documented in the medical records.’ Image
‘Higher levels of physical activity & #fitness are associated with lower all-cause mortality, lower rates of #cardiovascular disease, & lower prevalence of several known malignancies.’
‘Despite the substantial #health benefits provided by regular physical activity, intense #exercise may paradoxically act as a trigger for life-threatening ventricular arrhythmias in the presence of underlying #cardiovascular disease.’
‘Pre-participation #cardiovascular screening aimed at the detection of disorders associated with sudden cardiac death is universally supported by major medical societies.’
‘However, the best method for screening of young competitive #athletes (<35 years old) remains controversial, & limited data are available to guide recommendations in master athletes (≥35 years old).’
2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease: #ESCCongress academic.oup.com/eurheartj/adva…
‘The exercise test also permits an assessment of any abnormal #cardiovascular responses that might not otherwise be apparent during usual daily activities (including symptoms, ECG abnormalities, arrhythmias, or abnormal BP response).’
‘Based on the #exercise testing results, the physician may indicate the intensity, mode, & duration of exercise that appears most suitable to the individual patient’
‘Guidelines recommend healthy adults perform a minimum of 150min of moderate-intensity endurance #exercise over 5 days or 75min of vigorous exercise per week over 3 days, with additional benefit derived by doubling to 300min of moderate or 150min of vigorous-intensity per week.’
‘While a normal #exercise test & a high exercise capacity is associated with a good prognosis, the test has limited sensitivity in diagnosing mild to moderate obstructive coronary artery disease.’
‘Currently there is no evidence for incorporating routine cardiac imaging in pre-participation screening among asymptomatic individuals aged >35 years old with a normal exercise stress test.’
‘However, in asymptomatic adults considered to be at high risk or very high risk (#diabetes, strong family history of CAD, previous risk assessment suggesting high risk for CAD) a functional imaging test or coronary computed tomography angiography should be considered‘
‘Identification of atherosclerotic coronary artery disease should prompt aggressive management of risk factors & preventive medical treatment. Among individuals with proven obstructive coronary artery disease, further assessment & treatment is indicated.’
2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease: #ESCCongress academic.oup.com/eurheartj/adva…
Image
‘intervention with #statins, is superior to exercise & lifestyle intervention alone for reducing LDL #cholesterol & improving prognosis.Despite minor effects of #endurance #exercise on LDL, the relationship between increased fitness & reduced CV events is beyond statins.’
‘In patients with pre-#diabetes or metabolic syndrome, both aerobic and resistance #exercise may prevent the development of overt diabetes.’
Exercise recommendations for people with #obesity, #diabetes, #hypertension & dyslipidaemia: Image
‘Moderate-intensity #exercise is generally safe for older healthy people & medical consultation before starting or progressing the level of exercise programme is not usually required.’ #elderly #ESCCongress
Exercise ‘prescription’ for the #elderly: Image
Image
#Athletes or individuals participating in sports or regular exercise training may have risk factors for coronary artery disease &/or subclinical Chronic Coronary Syndrome. Such individuals may be identified by routine pre-participation screening as recommended by the ESC.’
Evaluation of asymptomatic individuals with possible subclinical Chronic Coronary Syndrome:
1Assessment of CVD risk
2Consideration of intensity of intended exercise
3Clinical evaluation, including maximal exercise stress test
4Further diagnostic testing in selected
Many middle-aged individuals in can be expected to have some level of subclinical Chronic Coronary Syndrome as assessed with imaging techniques.
‘Anatomical coronary imaging alone does not provide information relating to the coronary flow & reserve, which is important in assessing the risk of ischaemia / arrhythmia/death; therefore functional evaluation is necessary.’

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More from @cpgale3

Sep 28, 2020
This nationwide complete analysis of all adult deaths in #England & #Wales has found that the #COVID pandemic has resulted in an abrupt inflation in acute #cardiovascular deaths above that expected for the time of year. heart.bmj.com/content/early/…
That is, about 2000 additional deaths over a 4 month period.
Nearly half of the deaths occurred outside of the #hospital setting, either at #home or in #carehomes.
Read 23 tweets
Sep 23, 2020
Emerging data from @PHE_uk suggests a synergistic detrimental effect of co-infection with #SARS_CoV_2 & #flu viruses. The preprint (not peer reviewed) article is available here medrxiv.org/content/10.110…
‘The risk of testing positive for #SARS_CoV_2 was 68% lower among #influenza positive cases, suggesting possible pathogenic competition between the two viruses.’
However, ‘Patients with a coinfection had a risk of death of 5.92 (95% CI, 3.21-10.91) times greater than among those with neither influenza nor SARS-CoV-2 suggesting possible synergistic effects in coinfected individuals.’
Read 7 tweets
Sep 20, 2020
Advances in #cancer treatment have improved clinical outcomes, leading to an increasing population of cancer survivors. Yet, this success is associated with high rates of short‐ & long‐term #cardiovascular toxicities. The Cancer Patient and Cardiology onlinelibrary.wiley.com/doi/abs/10.100…
The number & variety of #cancer drugs & #cardiovascular toxicity types make long‐term care a complex undertaking.
This requires a multidisciplinary approach including expertise from #oncology, #cardiology, & other related specialties, & has led to the development of the cardio‐oncology subspecialty.
Read 10 tweets
Sep 20, 2020
The rise in admissions with #COVID19 does not mean that you shouldn’t attend hospital if you have a medical emergency #heartattack Image
During the first peak, admissions with #heartatrack declined & was of grave concern : COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England @TheLancet thelancet.com/journals/lance…
Yet, hospitals provided high quality care for those who did attend: Patient response, treatments and mortality for acute myocardial infarction during the COVID-19 pandemic @ESC_Journals #EHJQCCO academic.oup.com/ehjqcco/advanc…
Read 6 tweets
Sep 19, 2020
Subsequent to #Surgisphere, all @TheLancet journals will now introduce additional peer-review requirements for papers based on large, real-world #datasets. thelancet.com/journals/lance…
@TheLancet journals now require all #research papers, irrespective of method, to include a data-sharing statement that details what #data will be shared, whether additional documents will be shared, when data will become available & by what access criteria data will be shared.
All @TheLancet journals will now introduce additional peer-review requirements for papers based on large, real-world datasets.
Read 10 tweets
Sep 19, 2020
Patients with mitral annular disjunction present with frequent premature ventricular contractions; in this study, one-third had ventricular arrhythmias & one-tenth had severe arrhythmic events. @JACCJournals onlinejacc.org/content/72/14/…
A total of 82 (71%) patients reported #palpitations, 47 (41%) patients reported previous pre-syncope, 40 (34%) had ventricular arrhythmia, 15 (13%) had experienced #syncope, & 14 (12%) patients had experienced a severe arrhythmic event prior to inclusion
Mitral valve prolapse was present in 90 (78%) patients
Read 10 tweets

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